toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0869-7922-2025-33-5-337-346wsenkutoxreview-1023Research ArticleПРОФИЛАКТИЧЕСКАЯ ТОКСИКОЛОГИЯPREVENTIVE TOXICOLOGYПрименение методов метаболомики в качестве инструмента оценки профессионального риска (обзор литературы)Application of metabolomics methods as an occupational risk assessment tool (literature review)https://orcid.org/0009-0000-6619-2744ОрловаОльга ИгоревнаOrlovaOlga I.

Ведущий научный сотрудник, кандидат хим. наук, ФГУП «НИИ гигиены, профпатологии и экологии человека» ФМБА России 188663, Ленинградская область, г. пос. Кузьмоловский, Россия

e-mail: orlova@yandex.ru

Candidate of Chemical Sciences, Leading Researcher, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, Leningrad region, Kuzmolovsky settlement, 188663, Russian Federation

e-mail: orlova@yandex.ru 

orlova@yandex.ruhttps://orcid.org/0000-0002-2911-1260УколовАнтон ИгоревичUkolovAnton I.

Кандидат хим. наук; заведующий отделом токсикологии ФГУП «НИИ гигиены, профпатологии и экологии человека» ФМБА России, 188663, Ленинградская область, г. пос. Кузьмоловский, Россия

e-mail: ukolov.ai@gpech.ru

Candidate of Chemical Sciences, Head of the Department of Toxicology, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, Leningrad region, Kuzmolovsky settlement, 188663, Russian Federation

e-mail: Ukolov.ai@gpech.ru

ukolov.ai@gpech.ruhttps://orcid.org/0000-0003-0776-7434РадиловАндрей СтаниславовичRadilovAndrei S.

Доктор мед. наук, профессор; и. о. директора ФГУП «НИИ гигиены, профпатологии и экологии человека» ФМБА России, 188663, Ленинградская область, г. пос. Кузьмоловский, Россия

e-mail: a.radilov@icloud.com

Doctor of Medical Sciences, Professor, Acting Director, Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia, 188663, Russian Federation, Leningrad region, Leningrad region, Kuzmolovsky settlement,188663, Russian Federation

e-mail: no-reply@subs.elpub.ru

a.radilov@icloud.comФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» ФМБА РоссииРоссияScientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agensy of RussiaRussian FederationФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» ФМБА России; ФГБУ «Научно-клинический центр токсикологии имени академика С.Н. Голикова»РоссияScientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agensy of Russia; Federal State-Financed Institution Golikov Scientific Research Clinical Center of ToxicologyRussian Federation202524112025335337346Copyright © Орлова О.И., Уколов А.И., Радилов А.С., 20252025Орлова О.И., Уколов А.И., Радилов А.С.Orlova O.I., Ukolov A.I., Radilov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/1023

Внедрение омиксных технологий в различные области медицины в последние годы ускоряется и является чрезвычайно актуальным для промышленной медицины. Определение биомаркеров, позволяющих выявить предикторы патологии, а также индивидуальную чувствительность к вредным условиям труда способствует снижению профессиональных рисков здоровью персонала.

В статье проанализированы 84 литературных источника, посвящённых проблематике биомониторинга в контексте применения методов метаболомики в области промышленной медицины.

На основании анализа как зарубежных, так и отечественных литературных источников, включая статьи в научно-исследовательских журналах, монографии, методические указания, собраны и проанализированы данные о применении методов метаболомики в медицине. Выявлена перспективность данного направления. Рассмотрены существующие достоинства и ограничения метаболомики в области гигиены труда.

Применение методов метаболомики открывает широкие перспективы в области персонализированной медицины. Мониторирование метаболических показателей работников, занятых во вредных производствах, вносит существенный вклад в обеспечение безопасности работ и позволяет выявить преморбидные состояния, тем самым снижая вероятность осложнений в течение заболевания.

Участие авторов

Участие авторов: Орлова О.И. – сбор литературных данных, написание теста, редактирование; Уколов А.И., Радилов А.С. – редактирование. Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех её частей.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки

Поступила в редакцию

Поступила в редакцию: 14 августа 2025 / Поступила после исправления: 09 сентября 2025/ Принята в печать: 02 октября 2025 / Опубликована: 19 ноября 2025

The implementation of omix technologies in various fields of medicine has been accelerating in recent years and is extremely relevant for industrial medicine. The identification of biomarkers that identify predictors of pathology, as well as individual sensitivity to harmful working conditions, helps reduce occupational health risks.

The article analyzes 84 literary sources devoted to the problems of biomonitoring in the context of the application of methods of metabolomicsin the field of industrial medicine.

Based on the analysis of data from both foreign and domestic literary sources, including articles in research journals, monographs, and guidelines, data on the use of metabolomics methods in medicine have been collected and analyzed. The prospects of this direction are revealed. The existing advantages and limitations of metabolomicsin the field of occupational health are considered.

The use of metabolomics methods opens up broad prospects in the field of personalized medicine. Monitoring the metabolic parameters of workers engaged in harmful industries makes a significant contribution to ensuring the safety of work and makes it possible to identify premorbid conditions, thereby reducing the likelihood of complications during the course of the disease.

Authors’ contribution

Authors’ contribution: Orlova O.I. – collecting literary data, writing a test, editing; Ukolov A.I., Radilov A.S. – editing. All co-authors – approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interests

Conflict of interests. The author declare no conflict of interest.

Funding

Funding. The study had no sponsorship.

Received

Received: August 14, 2025 / Revised: September 09, 2025 / Accepted: October 2, 2025 / Published: November 19, 2025

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The authors declare that there are no conflicts of interest present.