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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">toxreview</journal-id><journal-title-group><journal-title xml:lang="ru">Токсикологический вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Toxicological Review</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-7922</issn><issn pub-type="epub">3034-4611</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36946/0869-7922-2019-2-16-21</article-id><article-id custom-type="elpub" pub-id-type="custom">toxreview-183</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ТОКСИЧНОСТИ КООРДИНАЦИОННЫХ СОЕДИНЕНИЙ ГЕРМАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кадомцева</surname><given-names>A. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kadomtsevа</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жданович</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdanovich</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пискунова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Piskunovа</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Линева</surname><given-names>A. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lineva</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>A. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинов</surname><given-names>П. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">rector@pimunn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» МЗ РФ, 603950, ГСП-470, г. Нижний Новгород</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>16</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кадомцева A.В., Жданович И.В., Пискунова М.С., Линева A.Н., Новикова A.Н., Логинов П.A., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кадомцева A.В., Жданович И.В., Пискунова М.С., Линева A.Н., Новикова A.Н., Логинов П.A.</copyright-holder><copyright-holder xml:lang="en">Kadomtsevа A.V., Zhdanovich I.V., Piskunovа M.S., Lineva A.N., Novikova A.N., Loginov P.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.toxreview.ru/jour/article/view/183">https://www.toxreview.ru/jour/article/view/183</self-uri><abstract><p>В настоящее время перспективным направлением является синтез биологически активных координационных соединений и создание на их основе эффективных фармакологических препаратов. В работе исследованы дигерман, а также его производные комплексы. Приведены токсикологические исследования синтезированных соединений. Следует отметить, что позитивные лекарственные свойства металлоорганических соединений германия подтверждены множеством исследований, дальнейшее изучение методов синтеза, физико-химических и фармакологических свойств этих соединений, является перспективной задачей.</p></abstract><trans-abstract xml:lang="en"><p>The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>токсикологические исследования</kwd><kwd>координационные соединения германия</kwd><kwd>металлорганические</kwd><kwd>ферроценовые соединения</kwd><kwd>биологическое действие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>toxicological studies</kwd><kwd>coordination compounds of germanium</kwd><kwd>organometallic</kwd><kwd>ferrocene compounds</kwd><kwd>biological action</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кадомцева А.В. 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