toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2019-3-46-50toxreview-197Research ArticleСтатьиПОТЕНЦИАЛЬНЫЕ НАПРАВЛЕНИЯ СОВЕРШЕНСТВОВАНИЯ АНТИДОТНОЙ ТЕРАПИИ ОТРАВЛЕНИЙ ЦИАНИДАМИPOTENTIAL DIRECTIONS OF THE IMPROVEMENT OF ANTIDOTE THERAPY OF CYANIDE POISONINGГладкихВ. Д.GladkikhV. D.

Гладких Вадим Дмитриевич, доктор медицинских наук, профессор, заместитель директора по науке

141402, г. Химки

Gladkikh Vadim Dmitrievich

141402, Khimki

Gladkich2007@rambler.ruВершининаГ. В.VershininaG. V.

Вершинина Галина Васильевна, научный сотрудник научно-организационного отдела

141402, г. Химки

Vershinina Galina Vasilevna

141402, Khimki

vershinina@atompharm.ruФГУП НПЦ «Фармзащита» Федерального медико-биологического агентстваРоссияResearch and Production Center “Pharmaceutical Protection”, Federal Medical Biological AgencyRussian Federation201928062019034650Copyright © Гладких В.Д., Вершинина Г.В., 20192019Гладких В.Д., Вершинина Г.В.Gladkikh V.D., Vershinina G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/197

В статье, на основании анализа литературы, обсуждаются перспективные направления разработки антидотной профилактики и терапии острых отравлений цианидами. На роль потенциальных антидотов цианидов, эффективных и безопасных при внутримышечной и внутрикостной инъекциях, ингаляционной и пероральной доставке, претендуют химические соединения, опосредующие антицианидную активность за счет стимуляции основных механизмов детоксикации эндогенного цианида: сульфанген, кобинамид, α-кетоглутаровая кислота.

The article on the basis of an analysis of the literature discusses promising areas for the development of antidote prophylaxis and treatment of acute cyanide poisoning. The chemical compounds mediating anticyanide activity by stimulating the main detoxification mechanisms of endogenous cyanide: sulfangen, cobinamide, α-ketoglutaric acid claimed to be potential cyanide antidotes, effective and safe for intramuscular and intraosseous injections, inhalation and oral administration.

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The authors declare that there are no conflicts of interest present.