toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2019-3-51-55toxreview-200Research ArticleСтатьиАГОНИСТЫ РЕЦЕПТОРОВ, АССОЦИИРОВАННЫХ СО СЛЕДОВЫМИ АМИИНАМИ, 1-ГО ПОДТИПА КАК ПОТЕНИЦАЛЬНАЯ МИШЕНЬ В ТЕРАПИИ ПСИХИЧЕСКИХ РАССТРОЙСТВ С НАРУШЕНИЯМИ ИМПУЛЬСИВНОКОМПУЛЬСИВНОГО КОНТРОЛЯTAAR1 AGONISTS AS A POTENTIAL TARGET IN THE THERAPY OF MENTAL DISORDERS WITH THE DEFICIT OF IMPULSIVE AND COMPULSIVE CONTROLСухановИ. М.SukhanovI. M.

Суханов Илья Михайлович, кандидат медицинских наук, заведующий лаборатории фармакологии поведения Института фармакологии им. А.В. Вальдмана Первого Санкт-Петербургского государственного университета им. акад. И.П. Павлова

197101, г. Санкт-Петербург

Sukhanov Ilya

197101, Saint Petersburg

ilia.sukhanov@gmail.comИнститут фармакологии им. А.В. Вальдмана; Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияA.V. Valdman Institute of Pharmacology, I.P. Pavlov First Saint Petersburg State Medical UniversityRussian Federation201928062019035155Copyright © Суханов И.М., 20192019Суханов И.М.Sukhanov I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/200

Рецепторы, ассоциированные со следовыми аминами, 1-го подтипа (TAAR1) —перспективная мишень для разработки новых фармакологических подходов к терапии различных нейропсихических расстройств. В настоящее время TAAR1 агонисты проходят клинические испытания как новые фармакологически активные агенты с антипсихотическим действием. При этом экспрессия TAAR1 и физиологическое значение этих рецепторов, как регуляторов активности катехоламинергических структур в ЦНС, позволяют предположить, что активация TAAR1 может оказывать терапевтическое действие у больных, страдающих такими психическими заболеваниями как обсессивно-компульсивное расстройство и синдром дефицита внимания с гиперактивностью, которые сопровождаются нарушениями импульсивнокомпульсивного контроля. Настоящая работа представляет собой попытку критической оценки существующего на данный момент массива данных, полученных в ходе тестирования TAAR1 лигандов в in vivo работах за последние 5 лет. Проведённый анализ позволяет предположить, что TAAR1 агонисты могут оказывать противокомпульсивное и иметь ограниченное противоимпульсивное действие при использовании в клинике.

Receptors associated with trace amines, 1st subtype (TAAR1), are the promising targets for the development of new pharmacological approaches to the treatment of various neuropsychiatric disorders. Currently TAAR1 agonists are undergoing clinical trials as new pharmacologically active agents with antipsychotic action. At the same time, the expression of TAAR1 and the physiological significance of these receptors as regulators of the activity of catecholaminergic structures in the Central nervous system suggest that the activation of TAAR1 can have a therapeutic effect in patients suffering from mental diseases such as obsessive-compulsive disorder and attention deficit hyperactivity disorder, which are accompanied by violations of impulsive and compulsive control. This paper is an attempt to critically evaluate the currently existing data set obtained during testing of TAAR1 ligands in in vivo studies over the past 5 years. The analysis suggests that TAAR1 agonists may provide and have a limited anti-compulsive effect when used in the clinic.

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The authors declare that there are no conflicts of interest present.