toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2019-5-12-20toxreview-228Research ArticleСтатьиМНОГОКАМЕРНАЯ МОДЕЛЬ КАК ИНСТРУМЕНТ АНАЛИЗА ТОКСИКОКИНЕТИЧЕСКОЙ РОЛИ РАСТВОРЕНИЯ ЭЛЕМЕНТООКСИДНЫХ НАНОЧАСТИЦ И ФАГОЦИТАРНОЙ РЕАКЦИИ НА ИХ ОТЛОЖЕНИЕ В ЛЁГКИХ ПРИ ХРОНИЧЕСКОЙ ИНГАЛЯЦИОННОЙ ЭКСПОЗИЦИИMULTI-CHAMBER MODEL AS AN INSTRUMENT FOR ANALYSIS OF THE TOXICOKINETIC ROLE OF SOLUBILITY OF ELEMENT OXIDE NANOPARTICLES AND PHAGOCYTIC REACTION TO THEIR DEPOSITION IN LUNGS IN CHRONIC INHALATION EXPOSUREКацнельсонБ. А.KatsnelsonB. A.

Кацнельсон Борис Александрович - доктор медицинских наук, профессор, заведующий отделом токсикологии и биопрофилактики

bkaznelson@etel.ruСутунковаМ. П.SutunkovaM. P.sutunkova@ymrc.ruКонышеваЛ. К.KonyshevaL. K.

Конышева Людмила Константиновна - кандидат медицинских наук, доцент кафедры церковно-исторических и гуманитарных дисциплин

Konysheva Ludmila Konstantinovna

konkl@yandex.ruСоловьеваС. Н.SolovyevaS. N.

Соловьева Светлана Николаевна - научный сотрудник отдела токсикологии и биопрофилактики

Solovyeva Svetlana Nikolaevna

solovyevasn@ymrc.ruМинигалиеваИ. А.MinigalievaI. A.

Минигалиева Ильзира Амировна - заведующий лабораторией промышленной токсикологии

ilzira@ymrc.ruГурвичВ. Б.GurvichV. B.

Гурвич Владимир Борисович –nдоктор медицинских наук, директор

gurvich@ymrc.ruПриваловаЛ. И.PrivalovaL. I.

Привалова Лариса Ивановна - доктор медицинских наук, профессор, заведующий лабораторией научных основ биологической профилактики

Privalova Larissa Ivanovna

privalova@ymrc.ruФБУН Екатеринбургский медицинский научный центр профилактики и охраны здоровья рабочих промпредприятий РоспотребнадзораРоссияEkaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the RospotrebnadzorRussian FederationЕкатеринбургская духовная семинарияРоссияEkaterinburg Theological SeminaryRussian Federation201928102019051220Copyright © Кацнельсон Б.А., Сутункова М.П., Конышева Л.К., Соловьева С.Н., Минигалиева И.А., Гурвич В.Б., Привалова Л.И., 20192019Кацнельсон Б.А., Сутункова М.П., Конышева Л.К., Соловьева С.Н., Минигалиева И.А., Гурвич В.Б., Привалова Л.И.Katsnelson B.A., Sutunkova M.P., Konysheva L.K., Solovyeva S.N., Minigalieva I.A., Gurvich V.B., Privalova L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/228

В статье прослежены этапы развития системной многокамерной модели, описывающей механизмы лёгочной задержки частиц при хронических ингаляционных экспозициях. Эта модель была впервые разработана и экспериментально испытана для разных условий экспозиции к полидисперсной пыли SiO2 или TiO2, а в дальнейшем успешно использована как базовая для анализа паттернов задержки наночастиц (НЧ) разного химического состава (Fe2O3, SiO2, NiO). Наиболее существенная адаптация её к условиям воздействия элементо-оксидных НЧ потребовалась ввиду необходимости учесть роль не только физиологических механизмов их элиминации, но также их растворимости «in vivo». Было найдено, что относительный вклад последней может быть разным для НЧ разной природы, причём в некоторых случаях доминирующим. Моделирование задержки NiO-НЧ свидетельствует также о том, что повреждение физиологических механизмов лёгочного клиренса особо токсичными наночастицами может сделать их лёгочную токсикокинетику нелинейной.

The paper retraces the development of a mechanistic multi-chamber model describing particle retention in lungs in chronic inhalation exposures. This model was first developed and experimentally tested for various conditions of exposure to polydisperse dusts of SiO2 or TiO2, and later successfully used as a basis for analyzing patterns in the retention of nanoparticles (NP) having different chemical compositions (Fe2O3, SiO2, NiO). The most significant adaptation of this model for exposure to element oxide NPs was due to the need to take into account not only the physiological mechanisms of their elimination, but also their solubility «in vivo». It has been found that the relative contribution of the latter might be different for nanoparticles of different nature and predominant in some cases. The modeling of NiO-NPs retention also suggests that damage to the physiological pulmonary clearance mechanisms by particularly toxic nanoparticles might result in lung toxicokinetics becoming nonlinear.

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The authors declare that there are no conflicts of interest present.