toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2019-5-54-59toxreview-235Research ArticleЭКОЛОГИЧЕСКАЯ ТОКСИКОЛОГИЯECOLOGICAL TOXICOLOGYТИРЕОИДНЫЙ СТАТУС МЫШЕВИДНЫХ ГРЫЗУНОВ ПРИ ВОЗДЕЙСТВИИ СИНТЕТИЧЕСКОГО ПИРЕТРОИДА ЦИПЕРМЕТРИНАTHYROID STATUS IN MOUSE-LIKE RODENTS UNDER THE INFLUENCE OF SYNTHETIC PYRETHROID CYPERMETHRINЧигринскийЕ. А.ChigrinskiE. A.

Чигринский Евгений Александрович - кандидат биологических наук, доцент кафедры биохимии.

644099, Омск

Chigrinski Eugene Alexandrovich

644099, Omsk

chigrinski@list.ruФГБОУ ВО Омский государственный медицинский университет Минздрава РоссииРоссияOmsk State Medical University, Ministry of Healthcare of the Russian FederationRussian Federation201928102019055459Copyright © Чигринский Е.А., 20192019Чигринский Е.А.Chigrinski E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/235

Цель данной работы - оценка тиреоидного статуса у мышевидных грызунов при воздействии синтетического пиретроида циперметрина.

Исследования проведены на 168 крысах-самцах (Rattus norvegicus) и 112 самцах красной полевки (Myodes rutilus). При моделировании острой интоксикации циперметрин вводили однократно в желудок в дозе Vi ЛД50 с последующим наблюдением за крысами в течение 30 суток, а за полевками -7 суток. При изучении хронической интоксикации циперметрин вводили крысам в дозе 1/100 ЛД50, а длительность эксперимента составляла 120 суток. Акарицидную обработку леса проводили на одногектарной площадке, а результаты отлова полевок и их тиреоидный статус сравнивали с полевками, пойманными на фоновой площадке.

Синтетический пиретроид циперметрин в условиях острого и хронического экспериментов вызывает изменение тиреоидного статуса у лабораторных крыс, что выражается в снижении уровня тиреоидных гормонов в сыворотке крови. При этом у крыс отмечается повышение уровня тиреотроп-ного гормона. Введение высокой дозы циперметрина (% ЛД50) самцам полевок в условиях полевого вивария также выявило чувствительность представителей данного вида к действию синтетических пиретроидов, что проявилось в снижении синтеза Т4 и Т3 в их щитовидных железах. Акарицидная обработка леса способствует временному изменению тиреоидного статуса у самцов красной полевки (Myodes rutilus), отловленных на территории обработанного участка, что, по-видимому, является следствием адаптивных изменений и миграционных процессов в популяции данного вида.

The aim of this work was to evaluate the thyroid status in mouse-like rodents under the influence of synthetic pyrethroid cypermethrin.

The studies were performed on 168 male rats (Rattus norvegicus) and 112 male red voles (Myodes rutilus). When simulating acute intoxication, cypermethrin was injected once into the stomach at a dose of lA LD50 followed by observation of rats for 30 days and voles for 7 days. When studying chronic intoxication, cypermethrin was administered to rats at a dose of 1/100 LD50, the duration of the experiment was 120 days. Acaricidal treatment of the forest was carried out on a one-hectare site, and the results of the capture of voles and their thyroid status were compared with voles caught on the background site.

Synthetic pyrethroid cypermethrin in acute and chronic experiments causes a change in thyroid status in laboratory rats, which is reflected in a decrease in the level of thyroid hormones in the blood serum. Moreover, there is an increase in the level of thyroid-stimulating hormone in rats. The introduction of a high dose of cypermethrin (A LD50) into male voles under field vivarium conditions also revealed the sensitivity of representatives of this species to the action of synthetic pyrethroids, which was manifested in a decrease in the synthesis of T4 and T3 in their thyroid glands. Acaricidal forest treatment contributes to a temporary change in thyroid status in male red field vole (Myodes rutilus) caught in the treated area, which, apparently, is a consequence of adaptive changes and migration processes in the population of this species.

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The authors declare that there are no conflicts of interest present.