toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2020-2-35-40toxreview-276Research ArticleСтатьиПоказатели антиоксидантной системы в отдаленный период после острого отравления нитратом ртути в экспериментеIndicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experimentБатоцыреноваЕ. Г.BatotsyrenovaE. G.

Батоцыренова Екатерина Геннадьевна, кандидат биологических наук, ведущий научный сотрудник лаборатории биохимической токсикологии и фармакологии ФГБУН «Институт токсикологии Федерального медико-биологического агентства»

192019, г. Санкт-Петербург; 194100, г. Санкт-Петербург

Batotsyrenova Ekaterina Gennad’evna

192019, Saint Petersburg; 194100, Saint Petersburg

bkaterina2009@yandex.ruВакуненковаО. А.VakunenkovaO. A.

Вакуненкова Ольга Александровна, научный сотрудник отдела токсикологии 

192019, г. Санкт-Петербург

Vakunenkova Olga Alexandrovna

192019, Saint Petersburg

volga-2303@yandex.ruЗолотоверхаяЕ. А.ZolotoverkhayaE. A.

Золотоверхая Екатерина Андреевна , кандидат биологических наук, старший научный сотрудник лаборатории биохимической токсикологии и фармакологии

192019, г. Санкт-Петербург

Zolotoverkhaya Ekaterina Andreevna

192019, Saint Petersburg

orzheskovskaya@mail.ruКашуроВ. А.KashuroV. A.

Кашуро Вадим Анатольевич, доктор медицинских наук, заведующий лабораторией биохимической токсикологии и фармакологии

192019, г. Санкт-Петербург

Kashuro Vadim Anatolyevich

192019, Saint Petersburg

kashuro@yandex.ruКостроваТ. А.KostrovaT. A.

Кострова Таисия Александровна, младший научный сотрудник лаборатории биохимической токсикологии и фармакологии

192019, г. Санкт-Петербург

Kostrova Taisia Alexandrovna

192019, Saint Petersburg

tasia.pcma.le4@mail.ruКубарскаяЛ. Г.KubarskayaL. G.

Кубарская Лариса Георгиевна, кандидат биологических наук, старший научный сотрудник лаборатории биохимической токсикологии и фармакологии

192019, г. Санкт-Петербург

Kubarskaya Larisa Georgyevna

192019, Saint Petersburg

larkub@yandex.ruЛапинаН. В.LapinaN. V.

Лапина Наталия Вадимовна, кандидат медицинских наук, заведующий отдела токсикологии ФГБУН «Институт токсикологии

192019, г. Санкт-Петербург

Lapina Natalia Vadimovna

192019, Saint Petersburg

lapina2005@inbox.ruЩепетковаК. М.ShchepetkovaK. M.

Щепеткова Кристина Михайловна, заместитель заведующего отделом подготовки кадров

192019, г. Санкт-Петербург

Shchepetkova Kristina Mihailovna

192019, Saint Petersburg

tesh_07@inbox.ruФГБУН «Институт токсикологии Федерального медико-биологического агентства»; ФГБУВО «Санкт-Петербургский государственный педиатрический медицинский университет»РоссияInstitute of Toxicology of the Federal Medical Biological Agency; Saint Petersburg State Pediatric Medical UniversityRussian FederationФГБУН «Институт токсикологии Федерального медико-биологического агентства»РоссияInstitute of Toxicology of the Federal Medical Biological AgencyRussian Federation202015052020023641Copyright © Батоцыренова Е.Г., Вакуненкова О.А., Золотоверхая Е.А., Кашуро В.А., Кострова Т.А., Кубарская Л.Г., Лапина Н.В., Щепеткова К.М., 20202020Батоцыренова Е.Г., Вакуненкова О.А., Золотоверхая Е.А., Кашуро В.А., Кострова Т.А., Кубарская Л.Г., Лапина Н.В., Щепеткова К.М.Batotsyrenova E.G., Vakunenkova O.A., Zolotoverkhaya E.A., Kashuro V.A., Kostrova T.A., Kubarskaya L.G., Lapina N.V., Shchepetkova K.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/276

В статье представлены экспериментальные данные о состоянии антиоксидантной системы в эритроцитах белых беспородных крыс через 1 и 3 месяца после острого отравления нитратом ртути в полулетальной дозе. В результате проведенных исследований было установлено, что данная форма интоксикации сопровождается выраженными изменениями состояния системы антиоксидантной защиты в эритроцитах отравленных животных (снижение концентрации восстановленного глутатиона, снижение активности супероксиддисмутазы и глутатионпероксидазы, повышение концентрации продуктов перекисного окисления липидов).

Показано, что в крови экспериментальных животных, содержание ртути остается повышенным на притяжении всего срока исследования.

Полученные результаты указывают на существенную значимость нарушений функционирования антиоксидантной системы в реализации отдаленных последствий острых отравлений ртутью. Обсуждены причины возникновения данных биохимических сдвигов и их роль в реализации отдаленных цитотоксических эффектов нитрата ртути.

The article presents experimental data on the state of the antioxidant system in red blood cells of white outbred rats 1 and 3 months after acute mercury nitrate poisoning with a semilethal dose. It has been established that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, and an increase in the concentration of lipid peroxidation products).

It has been shown that the mercury content in the blood of experimental animals remains elevated during the entire study period.

The results obtained indicate the importance of impaired functioning of the antioxidant system in the implementation of long-term consequences of acute mercury poisoning. The reasons for the occurrence of these biochemical shifts and their role in the development of the long-term cytotoxic effects of mercury nitrate are discussed.

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The authors declare that there are no conflicts of interest present.