toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2020-3-9-13toxreview-303Research ArticleСтатьиГЕНОТОКСИЧЕСКАЯ АКТИВНОСТЬ СМЕСЕЙ ПЕСТИЦИДОВGENOTOXIC ACTIVITY OF THE PESTICIDE MIXTUREShttps://orcid.org/0000-0001-9122-9465ИлюшинаН. А.IlyushinaN. A.

Илюшина Наталия Алексеевна кандидат биологических наук, заведующая отделом генетической токсикологии

Ilyushina Nataliya Alexeevna

141014, Mytishchi, Moscow Region

Ilyushina-na@mail.ruhttps://orcid.org/0000-0001-5067-5469РевазоваЮ. А.RevazovaYu. A.

Ревазова Юлия Анатольевна

доктор биологических наук, ведущий научный сотрудник отдела генетической токсикологии

141014, г. Мытищи Московской области

Revazova Yulia Anatolievna

141014, Mytishchi, Moscow Region

revazova013@gmail.comФБУН «Федеральный научный центр гигиены им. Ф.Ф. Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияF.F. Erisman Federal Research Center of Hygiene of RospotrebnadzorRussian Federation20202406202003913Copyright © Илюшина Н.А., Ревазова Ю.А., 20202020Илюшина Н.А., Ревазова Ю.А.Ilyushina N.A., Revazova Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/303

В последнее время с целью преодоления резистентности к отдельным пестицидам и повышения их эффективности постоянно разрабатываются и поступают на рынок препаративные формы, содержащие два действующих вещества и более. Смеси остаточных количеств пестицидов могут присутствовать в воде и продуктах питания и поступать в организм человека и животных. Однако комбинированное действие пестицидов на живые организмы, в том числе и на генетические структуры в клетках, изучено недостаточно и прогнозирование генотоксических эффектов их смесей на основе имеющихся данных пока не представляется возможным. Целью настоящего обзора являлся сбор и обобщение имеющейся в литературе информации о генотоксичности комбинаций пестицидов, полученной на разных объектах. Обсуждаются результаты исследований, проведенных в разных странах мира, приведены примеры обнаруженных синергетических, аддитивных и антагонистических эффектов, свидетельствующие о необходимости тестирования генотоксичности препаративных форм пестицидов, содержащих несколько действующих вещества, а также смесей совместно применяемых пестицидных препаратов с целью обеспечения безопасного применения пестицидов для здоровья населения.

In order to overcome resistance to individual pesticides and improve their effectiveness, formulations containing two or more active substances are constantly being developed and put on the market over recent years. Mixtures of residual amounts of pesticides can be present in water and food and enter the human and animal bodies. However, the combined effect of pesticides on living organisms, including genetic structures in cells, has not been studied enough and it is not yet possible to predict the genotoxic effects of their mixtures based on available data. The purpose of this review was to collect and summarize literature information on the genotoxicity of pesticide combinations obtained at different objects. The results of studies conducted in different countries of the world are discussed, examples of detected synergistic, additive and antagonistic effects are given, indicating the need for testing the genotoxicity of preparative forms of pesticides containing several active substances, as well as mixtures of jointly used pesticides in order to ensure the safe use of pesticides for public health.

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The authors declare that there are no conflicts of interest present.