toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2020-4-3-11toxreview-317Research ArticleСтатьиСУБХРОНИЧЕСКАЯ ЭКСПЕРИМЕНТАЛЬНАЯ ИНТОКСИКАЦИЯ КРЫС СВИНЦОМ И КАДМИЕМ КАК ФАКТОР ПОВРЕЖДЕНИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫLEAD AND CADMIUM SUBCHRONIC INTOXICATION IN RATS AS A FACTOR OF DAMAGE TO THE CARDIOVASCULAR SYSTEMКлиноваС. В.KlinovaS. V.

Клинова Светлана Владиславовна

научный сотрудник лаборатории промышленной токсикологии

620014, г. Екатеринбург

Klinova Svetlana Vladislavovna

620014, Yekaterinburg

klinova.svetlana@gmail.comМинигалиеваИ. А.MinigalievaI. A.

Минигалиева Ильзира Амировна

кандидат биологических наук, зав. лабораторией промышленной токсикологии

620014, г. Екатеринбург

Minigalieva Ilzira Amirovna

620014, Yekaterinburg

ilzira-minigalieva@yandex.ruПриваловаЛ. И.PrivalovaL. I.

Привалова Лариса Ивановна

доктор медицинских наук, профессор, главный научный сотрудник, зав. лабораторией научных основ биопрофилактики

620014, г. Екатеринбург

Privalova Larisa Ivanovna

620014, Yekaterinburg

privalovali@yahoo.comСутунковаМ. П.SutunkovaM. P.

Сутункова Марина Петровна

кандидат медицинских наук, врио директора

620014, г. Екатеринбург

Sutunkova Marina Petrovna

620014, Yekaterinburg

marinasutunkova@yandex.ruГурвичВ. Б.GurvichV. B.

Гурвич Владимир Борисович

доктор медицинских наук, научный руководитель центра

620014, г. Екатеринбург

Gurvich Vladimir Borisovich

620014, Yekaterinburg

gurvich@ymrc.ruРябоваЮ. В.RyabovaJu. V.

Рябова Юлия Владимировна

м.н.с. лаборатории научных основ биопрофилактики

620014, г. Екатеринбург

Ryabova Juliya Vladimirovna

620014, Yekaterinburg

ryabova@ymrc.ruСоловьеваС. Н.SolovjevaS. N.

Соловьева Светлана Николаевна

н.с. лаборатории токсикологии среды обитания

620014, г. Екатеринбург

Solovjeva Svetlana Nikolaevna

620014, Yekaterinburg

solovyevasn@ymrc.ruПановВ. Г.PanovV. G.

Панов Владимир Григорьевич

кандидат физико-математических наук, старший научный cотрудник лаборатории математического моделирования в экологии и медицине

620990, г. Екатеринбург

Panov Vladimir Grigorievich

620990, Yekaterinburg

vpanov@ecko.uran.ruВаламинаИ. Е.ValaminaI. E.

Валамина Ирина Евгеньевна

кандидат медицинских наук, старший научный сотрудник, заведующий

620109, г. Екатеринбург

Valamina Irina vgenievna

620109, Yekaterinburg

ivalamina@mail.ruЧернышовИ. Н.ChernishovI. N.

Чернышов Иван Николаевич

младший научный сотрудник лаборатории промышленной токсикологии

620014, г. Екатеринбург

Chernishov Ivan Nikolaevich

620014, Yekaterinburg

chernishov@ymrc.ruКацнельсонБ. А.KatsnelsonB. A.

Кацнельсон Борис Александрович

доктор медицинских наук, профессор, заслуженный деятель науки РФ, заведующий отделом токсикологии и биопрофилактики

620014, г. Екатеринбург

Katsnelson Boris Aleksandrovich

620014, Yekaterinburg

bkaznelson@etel.ruФБУН «Екатеринбургский медицинский – научный центр профилактики и охраны здоровья рабочих промпредприятий» РоспотребнадзораРоссияYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of RospotrebnadzorRussian FederationФБУН «Институт промышленной экологии» УрО РАНРоссияInstitute of Industrial Ecology, Urals Branch of the Russian Academy of SciencesRussian FederationЦентральная научно-исследовательская лаборатория Уральского государственного медицинского университетаРоссияCentral Research Laboratory, Ural State Medical UniversityRussian Federation20203107202004311Copyright © Клинова С.В., Минигалиева И.А., Привалова Л.И., Сутункова М.П., Гурвич В.Б., Рябова Ю.В., Соловьева С.Н., Панов В.Г., Валамина И.Е., Чернышов И.Н., Кацнельсон Б.А., 20202020Клинова С.В., Минигалиева И.А., Привалова Л.И., Сутункова М.П., Гурвич В.Б., Рябова Ю.В., Соловьева С.Н., Панов В.Г., Валамина И.Е., Чернышов И.Н., Кацнельсон Б.А.Klinova S.V., Minigalieva I.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Ryabova J.V., Solovjeva S.N., Panov V.G., Valamina I.E., Chernishov I.N., Katsnelson B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/317

Свинцово-кадмиевая интоксикация является фактором риска для здоровья рабочих медеплавильной промышленности и людей, проживающих на территориях, загрязняемых её эмиссиями. Субхроническая интоксикация моделировалась путем повторных внутрибрюшинных инъекций ацетата свинца и хлорида кадмия как изолированно, так и в комбинации, 3 раза в неделю в течение 6 недель. Найдено снижение частоты сердечных сокращений и показателей артериального давления при кадмиевой интоксикации, а также снижение скорости кровотока и повышение показателей артериального давления при свинцовой. На электрокардиограмме обнаружены увеличение длительности комплекса QRS при кадмиевой интоксикации, увеличение интервала QT и снижение изоэлектрической линии при комбинированном токсическом действии свинца и кадмия. Показаны уменьшение толщины кардиомиоцитов под влиянием кадмиевой интоксикации и увеличение – под влиянием свинцовой, а также уменьшение толщины внутренней оболочки стенки аорты при всех исследованных типах интоксикации. Любая токсическая экспозиция приводила к снижению числа ядер на единицу площади гистологического препарата миокарда.

Lead-cadmium intoxication is an occupational risk factor for copper-smelting industry workers. People inhabiting the areas near the copper plants are also at risk. Subchronic intoxication was modeled by repeated intraperitoneal injections of lead acetate and cadmium chloride both in isolation and in combination, 3 times a week for 6 weeks. A heart rate decrease in animals with Cd intoxication and a blood flow velocity decrease in those with Pb intoxication have been found. The impact of Pb and Cd on blood pressure proved to be contra-directional. ECG analysis revealed a prolonged duration of QRS in Cd intoxication, a prolonged QT interval and a baseline lowering in Pb+Cd intoxication. A variety of changes has been found with respect to the diameter of cardiomyocytes and the thickness of aortic wall layers in Pb and/or Cd intoxication. Any toxic exposure resulted in the decrease in number of nuclei per unit area of myocardium histological preparation.

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The authors declare that there are no conflicts of interest present.