toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2021-29-3-10-15toxreview-424Research ArticleОБЗОРЫREVIEWSСовременные представления о возможном участии алюминия в этиологии болезни АльцгеймераCurrent views on the possible involvement of aluminum in the etiology of Alzheimer's diseaseИваненкоН. Б.IvanenkoN. B.

Иваненко Наталья Борисовна - кандидат химических наук, ведущий научный сотрудник лаборатории токсикологической химии неорганических соединений ФГБУ НКЦТ им. академика С.Н. Голикова ФМБА России.

192019, Санкт-Петербург.

Natalya B. Ivanenko - PhD in Chemistry Sciences, Leading Researcher at the Laboratory of Toxicological Chemistry of Inorganic Compounds of the Golikov Research Center of Toxicology of the FMBA of Russian Federation.

192019, Saint-Petersburg.

nbivanenko@mail.ruГанеевА. А.GaneevA. A.

Ганеев Александр Ахатович - доктор физико-математических наук, профессор, заведующий химико-аналитическим отделом ФГБУН ИТ ФМБА России.

192019, Санкт-Петербург.

Aleksandr A. Ganeev.

192019, Saint Petersburg.

ganeev@lumex.ruЗубакинаЕ. А.ZubakinaE. A.

Зубакина Екатерина Александровна - кандидат химических наук, младший научный сотрудник лаборатории токсикологической химии неорганических соединений ФГБУН ИТ ФМБА России.

192019, Санкт-Петербург.

Еkaterina А. Zubakina.

192019, Saint Petersburg.

mihailova_katya@inbox.ruБезручкоМ. М.BezruchkoM. M.

Безручко Марина Митрофановна - кандидат химических наук, старший научный сотрудник лаборатории токсикологической химии неорганических соединений ФГБУН ИТ ФМБА России.

192019, Санкт-Петербург.

Мarina М. Bezruchko.

192019, Saint Petersburg.

bezrucko@mail.ruГубальА. Р.GubalA. R.

Губаль Анна Романовна - кандидат химических наук, младший научный сотрудник кафедры аналитической химии института химии СПбГУ.

Санкт-Петербург, 199034.

Anna R. Gubal.

199034, Saint Petersburg.

a.r.gubal@mail.ruЧучинаВ. А.ChuchinaV. A.

Чучина Виктория Александровна - аспирант кафедры аналитической химии института химии СПбГУ.

Санкт-Петербург, 199034.

Viktoriya А. Chuchina.

199034, Saint Petersburg.

vikky95bodnar@gmail.comЛитвинцевБ. С.LitvintsevB. S.

Литвинцев Богдан Сергеевич - доктор медицинских наук, заместитель главного врача по медицинской части клинико-диагностической поликлиники ФГБУН ИТ ФМБА России.

192019, Санкт-Петербург.

Bogdan S. Litvintsev.

192019, Saint Petersburg.

litvintsevs@yandex.ruНаучно-клинический центр токсикологии имени академика С.Н. Голикова Федерального медико-биологического агентстваРоссияGolikov Research Center of Toxicology of the Federal Medical and Biological AgencyRussian FederationСанкт-Петербургский Государственный Университет, Институт химииРоссияSaint Petersburg State University, Institute of ChemistryRussian Federation202118072021031015Copyright © Иваненко Н.Б., Ганеев А.А., Зубакина Е.А., Безручко М.М., Губаль А.Р., Чучина В.А., Литвинцев Б.С., 20212021Иваненко Н.Б., Ганеев А.А., Зубакина Е.А., Безручко М.М., Губаль А.Р., Чучина В.А., Литвинцев Б.С.Ivanenko N.B., Ganeev A.A., Zubakina E.A., Bezruchko M.M., Gubal A.R., Chuchina V.A., Litvintsev B.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/424

Цель исследования — изучить возможность использования содержания алюминия, как маркера нейродегенеративных заболеваний.

Материал и методы

Материал и методы. Для достижения поставленной цели был проведён анализ литературных источников из различных баз данных, в частности Scopus и PubMed.

Результаты

Результаты. Проведённый анализ показывает, что к настоящему времени накоплены серьёзные доказательства того, что определённые нейродегенеративные заболевания связаны с хроническим воздействием низких доз Al: в частности болезнь Альцгеймера (БА); болезнь двигательных нейронов или боковой амиотрофический склероз (БАС); рассеянный склероз (РС) и ряд других.

Заключение

Заключение. Таким образом, можно предположить, что измерение содержания Al в плазме крови, позволит выделить группу высокого риска возникновения БА, что позволит начать профилактическое лечение на наиболее ранней стадии заболевания. Возможности существующих методов анализа ICP-MS и GFASS позволяют решить эту задачу.

The aim of the study was to investigate the possibility of using а concentration of aluminum as a marker of neurodegenerative diseases.

Material and methods

Material and methods. To achieve this goal, there was carried out an analysis of literary origins from various databases, in particular Scopus and PubMed.

Results

Results. The analysis shows that by now there has been accumulated strong evidence that certain neurodegenerative diseases are associated with chronic exposure to low-dose of aluminum: in particular, Alzheimer's disease (AD); motor neuron disease or amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS) and a number of others.

Conclusion

Conclusion. Thus, it can be assumed that the measurement of the concentration of Al in the blood plasma will make it possible to identify a group people with of high risk of AD, which will allow starting preventive treatment at the earliest stage of the disease. The capabilities of the existing methods of analysis: atomic absorption spectrometry with electrothermal atomization (GFAAS) and inductively coupled plasma mass spectrometry (ICP-MS) enable to solve this problem.

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The authors declare that there are no conflicts of interest present.