toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erismantoxreview-452Research ArticleСтатьиИЗМЕНЕНИЯ ПРОФИЛЕЙ ЖИРНЫХ КИСЛОТ ПЛАЗМЫ КРОВИ КРЫС ПРИ ВВЕДЕНИИ СУБЛЕТАЛЬНЫХ КОЛИЧЕСТВ ФОСФОРОРГАНИЧЕСКИХ ОТРАВЛЯЮЩИХ ВЕЩЕСТВCHANGES IN PROFILES OF BLOOD PLASMA FATTY ACIDS IN RATS CAUSED BY ADMINISTRATION OF SUB-LETHAL AMOUNTS OF ORGANOPHOSPHOROUS TOXIC AGENTSУколовАнтон ИгоревичUkolovAnton Igorevich

Кандидат химических наук, старший научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: AntonUkolov@gmail.com

noemail@neicon.ruОрловаТатьяна ИгоревнаOrlovaTatyana Igorevna

Научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: orlovatatianagpeh@mail.ru 

noemail@neicon.ruСавельеваЕлена ИгоревнаSavelElena Igorevna

Доктор химических наук, заведующий лабораторией аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: ESavelieva59@mail.ru

noemail@neicon.ruРадиловАндрей СтаниславовичRadilovAndrey Stanislavovich

Доктор медицинских наук, профессор, заведующий отделом токсикологии, заместитель директора по научной работе ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: radilov@rihophe.ru

noemail@neicon.ruГончаровНиколай ВасильевичGoncharovNikolay Vasilievich

Доктор биологических наук, ведущий научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: ngoncharov@gmail.com 

noemail@neicon.ruФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» ФМБА РоссииРоссияResearch Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological AgencyRussian Federation20151208202103211Copyright © Уколов А.И., Орлова Т.И., Савельева Е.И., Радилов А.С., Гончаров Н.В., 20212021Уколов А.И., Орлова Т.И., Савельева Е.И., Радилов А.С., Гончаров Н.В.Ukolov A.I., Orlova T.I., Savel E.I., Radilov A.S., Goncharov N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/452

Впервые исследовано влияние зарина (GB), зомана (GD) и российского вещества Vx (RVX) без применения и с применением антидотных препаратов (карбоксим или карбоксим в смеси с атропином) на качественный и количественный состав свободных и этерифицированных жирных кислот (СЖК и ЭЖК, соответственно) плазмы крови. Введение крысам доз GB и GD на уровне ½DL50 вызывает уменьшение концентраций СЖК в плазме крови через 3 часа. Через 24 часа уровень СЖК возвращается к норме. Введение 2 0.4DL50 RVX обусловливает повышенный уровень ЭЖК и СЖК в плазме крови в течение недели, в том числе обогащение полиненасыщенными кислотами фракции СЖК. Антидотная терапия нормализует динамику СЖК и ЭЖК, но не предотвращает изменения их уровней в первые часы. RVX в отличие от фосфорорганических пестицидов на уровне ½DL50 ингибирует ацетилхолинэстеразу (АХЭ), но не влияет на липидный обмен в первые 24 часа.

For the first time an investigation was conducted into the influence of sarin (GB), soman (GD) and Russian substance Vx (RVX) with and without application of antidotal preparations ( carboxin and carboxin mixed with atropine) on the qualitative and quantitative composition of free and etherified fatty acids at the level of ½LD50 (FFA and EFA correspondingly) in the blood plasma. Administration of GB and GD doses at the level of ½LD50 to rats causes a decrease of FFA in blood plasma after 3 hours. 24 hours later the FFA returns to the normal level. Administration of 2x0.4 LD50 RVX conditions an elevated level of FFA and EFA in the blood plasma throughout a week including enrichment of the FFA fraction with polyunsaturated acids. Antidotal therapy normalizes the FFA and EFA dynamics but does not prevent changes in their levels over first hours. Unlike organophosphorous pesticides, RVX at the level of ½LD50 inhibits acetyl cholinesterase but does not affect lipid exchange over first 24 hours.

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The authors declare that there are no conflicts of interest present.