toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erismantoxreview-457Research ArticleСтатьиИЗМЕНЕНИЕ ГУМОРАЛЬНЫХ И КЛЕТОЧНЫХ ИММУННЫХ РЕАКЦИЙ, ФУНКЦИИ TH1-, TH2-ЛИМФОЦИТОВ И КОНЦЕНТРАЦИИ ЦИТОКИНОВ В КРОВИ ПОСЛЕ ХРОНИЧЕСКОЙ ИНТОКСИКАЦИИ ТРИХЛОРЭТИЛЕНОМTHE CHANGE OF HUMORAL AND CELLULAR IMMUNE RESPONSES, OF TH1-, TH2- LYMPHOCYTES FUNCTIONS AND CYTOKINE CONCENTRATIONS IN BLOOD AFTER CHRONIC INTOXICATION WITH TRICHLOROETHYLENEЗабродскийП. Ф.ZabrodskiiP. F.noemail@neicon.ruМасляковВ. В.MaslyakovV. V.noemail@neicon.ruГромовМ. С.GromovM. S.noemail@neicon.ru201512082021034043Copyright © Забродский П.Ф., Масляков В.В., Громов М.С., 20212021Забродский П.Ф., Масляков В.В., Громов М.С.Zabrodskii P.F., Maslyakov V.V., Gromov M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/457

В экспериментах на аутбредных белых крысах установлено, что хроническая интоксикация трихлорэтиленом (30 сут, ежедневно подкожно 0,05 DL50), в большей степени снижала активность Th2-клеток по сравнению с Th1-лимфоцитами, а также гуморальные иммунные реакции по сравнению с клеточным иммунным ответом. Трихлорэтилен уменьшал содержание в крови иммунорегуляторных цитокинов ИФН- , ИЛ-2, ИЛ-4 и увеличивал концентрацию провоспалительного цитокина ИЛ-6, незначительно повышал содержание в крови антивоспалительных цитокинов ИЛ-10, ИЛ-13.

It was established in experiments on non-inbred albino rats that chronic intoxication with trichlorethylene (30 days, subcutaneously daily 0.05 LD50) ) largely decreased Th2- cells activity as compared to Th1-lyphocytes and as well as humoral immune responses as compared to the cellular immune response. Trichloroethylene decreased levels of immune regulatory cytokines IFN-γ, IL-2, IL-4 in blood ,increased the concentration of pro-inflammatory cytokine IL-6, and insignificantly raised levels of anti-inflammatory cytokines IL-10, IL-13 in blood.

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The authors declare that there are no conflicts of interest present.