<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">toxreview</journal-id><journal-title-group><journal-title xml:lang="ru">Токсикологический вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Toxicological Review</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-7922</issn><issn pub-type="epub">3034-4611</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">toxreview-496</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ВРЕДНЫХ ПРОИЗВОДСТЕННЫХ ФАКТОРОВ НА РАЗВИТИЕ БРОНХОЛЕГОЧНОЙ ПАТОЛОГИИ У РАБОТНИКОВ ЭЛЕКТРОЛИЗНОГО ПЕРЕДЕЛА НИКЕЛЯ</article-title><trans-title-group xml:lang="en"><trans-title>INFLUENCE OF HARMFUL OCCUPATIONAL FACTORS ON THE DEVELOPMENT OF BRONCHOPULMONARY PATHOLOGY IN ELECTROLYTIC NICKEL PRODUCTION WORKERS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шилов</surname><given-names>Виктор Васильевич</given-names></name><name name-style="western" xml:lang="en"><surname>Shilov</surname><given-names>Victor Vasilevich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, директор ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация</p><p>e-mail: vshilov@inbox.ru</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сюрин</surname><given-names>Сергей Алексеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Syurin</surname><given-names>Sergei Alexeevich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, главный научный сотрудник отдела гигиены ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора, 191036, г. Санкт-Петербург, Российская Федерация</p><p>e-mail: kola.reslab@mail.ru </p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное бюджетное учреждение науки «Северо-Западный научный центр гигиены и общественного здоровья» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Northwest Scientific Center of Hygiene and Public Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>4</issue><fpage>6</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шилов В.В., Сюрин С.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Шилов В.В., Сюрин С.А.</copyright-holder><copyright-holder xml:lang="en">Shilov V.V., Syurin S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.toxreview.ru/jour/article/view/496">https://www.toxreview.ru/jour/article/view/496</self-uri><abstract><p>Цель исследования заключалась в изучении влияния вредных производственных факторов электролизного производства никеля на состояние респираторного здоровья 1530 работников никелевой промышленности. Установлено, что пятая часть работников входит в группу риска формирования хронических бронхолегочных заболеваний (ХБЛЗ). Также почти у пятой части обследованных лиц имеются клинически сформированные ХБЛЗ, среди которых наиболее распространены хронический бронхит (12%) и токсический пневмосклероз (6%). Наиболее высокий риск развития хронического бронхита отмечается у экспонированных групп работников: электролизники (ОР=1,87), аппаратчики-гидрометаллурги (ОР=1,55), слесари-ремонтники (ОР=1,55). Патогенетические механизмы, определяющие развитие у работников никелевой промышленности той или иной нозологической формы ХБЛЗ (хронический бронхит, хроническая обструктивная болезнь легких, астма, токсический пневмосклероз) требуют дальнейшего изучения. Сделан вывод о необходимости совершенствования системы технических и медицинских мер профилактики ХБЛЗ у работников никелевой промышленности.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of the study was to investigate the influence of harmful factors of electrolysis nickel production on the state of respiratory health in 1530 nickel industry workers. It was found that one-fifth of the workers are at risk of forming chronic bronchopulmonary disease (CBPD). In about one-fifth of those examined, clinically formed CBPDs have already developed, among which the most prevalent diseases were chronic bronchitis (12%) and toxic pulmonary fibrosis (6%). The highest risk of developing chronic bronchitis was observed in the most exposed groups of workers: electrolysis operators (RR = 1.87), hydrometallurgical equipment operators (RR = 1.55) and fitters-repairmen (RR = 1.55). Up to now there is no clear understanding of pathogenetic mechanisms underlying the development of a particular nosological form of CBPD (chronic bronchitis, chronic obstructive pulmonary disease, asthma, chronic pulmonary fibrosis) in nickel industry workers. The conclusion is made about the need to improve the system of technical and medical measures for prevention of CBPD in nickel industry workers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аэрозоли соединений никеля</kwd><kwd>бронхолегочные заболевания</kwd><kwd>работники никелевой промышленности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>aerosols of nickel compounds</kwd><kwd>bronchopulmonary diseases</kwd><kwd>nickel industry workers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Артюнина Г.П., Игнатькова С.А., Гробова, О.М. Петухов Р. В. Морфологическая характеристика изменений в легких экспериментальных животных при интратрахеальном введении сульфата никеля. Пульмонология. 83-79 :4 ;1996.</mixed-citation><mixed-citation xml:lang="en">Artyunina G.P., Ignatkova S.A., Grobova O.M., Petukhov R.V. Morphological characteristics of changes in the lungs of experimental animals after intratracheal administration of nickel sulphate. Pul’monologija. 83-79 :4 ;1996 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Casarett and Doulls Toxicology: The basic science of poisons. Ed. C.D. Klaassen P. McGraw – Hill Companies Inc., 839-837 ,650-649 :2001.</mixed-citation><mixed-citation xml:lang="en">Casarett and Doulls Toxicology: The basic science of poisons. Ed. C.D. Klaassen P. McGraw - Hill Companies Inc., 839-837 ,650-649 :2001.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Профилактика профессиональных заболеваний органов дыхания и периферической нервной системы у работников никелевой промышленности Севера России: Пособие для врачей. Санкт-Петербург, 20</mixed-citation><mixed-citation xml:lang="en">Prevention of occupational diseases of respiratory organs and peripheral nervous system in nickel industry workers of the Russian North: Manual for doctors. St.Petersburg, 2010 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Тарновская Е. В., Сюрин С. А., Чащин В. П. Общая и профессиональная болезненность работников электролизного производства никеля в Кольском Заполярье. Медицина труда и промышленная экология. :4 ;2010 14-11.</mixed-citation><mixed-citation xml:lang="en">Tarnovskaya E.V., Syurin S.A., Chashchin V.P. General and occupational morbidity of workers employed in electrolysis production of nickel in the Kola North. Medicina truda i promyshlennaja jekologija. -11:4 ;2010 14 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kiilunen M., Atio A., Tossavainent A. Occupational exposure to nickel salts in electrolytic planting. Ann. Occup. Hyg. 200-189 :)2( 41 ;1997.</mixed-citation><mixed-citation xml:lang="en">Kiilunen M., Atio A., Tossavainent A. Occupational exposure to nickel salts in electrolytic planting. Ann. Occup. Hyg. 200-189 :(2) 41 ;1997.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по гигиенической оценке факторов рабочей среды и трудового процесса. Критерии и классификация условий труда: (Руководство -2.2.2006 05). М., 2005.</mixed-citation><mixed-citation xml:lang="en">Manual on hygienic evaluation of working environment and working process factors. Criteria and classification of work conditions. Manual -2.2.2006Moscow, 2005 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова И. С. Токсический пневмосклероз. В кн.: Измеров Н. Ф., ред. Профессиональные заболевания. Т. М.: Медицина, 84 :1996–</mixed-citation><mixed-citation xml:lang="en">Ivanova I.S. Toxic pulmonary fibrosis. In: Izmerov N.F., ed. Occupationaldiseases. Vol. Moscow: Meditsina: :1996 88-84 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2013). Available from: www.goldcopd.com</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2013). Available from: www.goldcopd.com</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 20Available from: http://www.ginasthma.org</mixed-citation><mixed-citation xml:lang="en">Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 20Available from: http://www.ginasthma.org</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Сюрин С. А. Особенности формирования профессиональной патологии у работников различных переделов никеля в условиях Крайнего Севера. Безопасность и охрана труда. 51-50 :1 ;2012.</mixed-citation><mixed-citation xml:lang="en">Syurin S.A. Features of development of occupational diseases among workers in different types of nickel production in the Far North. Bezopasnost’ i ohrana truda. 51-50 :1 ;2012 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Артюнина Г. П. Токсический пневмосклероз и альвеолит у рабочих гидрометаллургического производства никеля. Медицина труда и промышленная экология. :3 ;1996 25-22.</mixed-citation><mixed-citation xml:lang="en">Artyunina G.P. Toxic pulmonary fibrosis and alveolitis in hydrometallurgical nickel production workers. Medicina truda i promyshlennaja jekologija. 25-22:3 ;1996 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева О. С. Профессиональная астма: клинические варианты. Пульмонология. 68-61 :5 ;2005.</mixed-citation><mixed-citation xml:lang="en">Vasilyeva O.S. Occupational asthma: clinical variants. Pul’monologya. :5 ;2005 68-61 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mapp C.E., Boschetto P., Maestrelli P., Fabbri L.M. Occupational asthma. Am. J. Respir. Crit. Care Med. :172 ;2005 305–280.</mixed-citation><mixed-citation xml:lang="en">Mapp C.E., Boschetto P., Maestrelli P., Fabbri L.M. Occupational asthma. Am. J. Respir. Crit. Care Med. :172 ;2005 305-280.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kongerud J., Boe J, Soyseth V., Naalsund A., Magnus P. Aluminum potroom asthma: the Norwegian experience. Respir. 172-165 ;7 :1994.</mixed-citation><mixed-citation xml:lang="en">Kongerud J., Boe J, Soyseth V., Naalsund A., Magnus P. Aluminum potroom asthma: the Norwegian experience. Respir. 172-165 ;7 :1994.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
