toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2017-2-27-34toxreview-66Research ArticleСтатьиПЕРСПЕКТИВНЫЕ НАПРАВЛЕНИЯ КОРРЕКЦИИ НЕЙРОТОКСИЧЕСКИХ НАРУШЕНИЙ ПРИ ПОРАЖЕНИИ МОНООКСИДОМ УГЛЕРОДА (ОБЗОР ЛИТЕРАТУРЫ)PROSPECTIVE METHODS FOR CORRECTION OF NEUROTOXIC IMPAIRMENTS CAUSED BY SEVERE CARBON MONOXIDE POISONING (REVIEW)ТолкачП. Г.TolkachP. G.noemail@neicon.ruБашаринВ. А.BasharinV. A.noemail@neicon.ruСарманаевС. Х.SarmanaevS. Kh.noemail@neicon.ruФГБВОУ ВО «Военно-медицинская академия им. С.М.Кирова» МО РФРоссияS.M. Kirov Military Medical Academy”, RF Ministry of DefenseRussian FederationФНКЦ ФХМ ФМБА РоссииРоссияFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyRussian Federation201728042017022734Copyright © Толкач П.Г., Башарин В.А., Сарманаев С.Х., 20172017Толкач П.Г., Башарин В.А., Сарманаев С.Х.Tolkach P.G., Basharin V.A., Sarmanaev S.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/66

В обзоре представлены перспективные направления коррекции нейротоксических нарушений при поражении монооксидом углерода. Показано, что интоксикация монооксидом углерода, помимо развития гемической гипоксии, приводит к опосредованному повреждению структур центральной нервной системы, которые развиваются как в раннем, так и отдалённом периоде отравления. Эти повреждения могут быть обусловлены развитием оксидативного стресса, активацией программируемой клеточной гибели, воздействием на систему межклеточной сигнализации и др. Имеются данные о том, что монотерапия кислородом не приводит к полному восстановлению когнитивных функций в отдалённом периоде тяжёлого отравления монооксидом углерода. Установлено, что для коррекции нарушений функций центральной нервной системы при остром поражении монооксидом углерода необходимо применять средства, обладающими нейропротекторными механизмами действия. В обзоре представлены данные об эффективности применения гидрогенированного раствора, раствора метана, аллопуринола, эритропоэтина, гранулоцитарного колониестимулирующего фактора, ремифентанила, мезенхимальных стволовых клеток, церебролизина для коррекции нарушения функций центральной нервной системы при данном виде патологии.

The review sets forth perspective directions of correction of neurotoxic disorders in case of carbon monoxide damage. It was shown that carbon monoxide intoxication, in addition to the development of hemic hypoxia, leads to indirect lesions in the structures of the central nervous system that develop both in the early and delayed periods of poisoning. Those lesions can be caused by the development of oxidative stress, activation of programmed cell death, impact on the intercellular signaling system etc. There is evidence that oxygen monotherapy does not lead to a complete recovery of cognitive functions in a delayed period of severe carbon monoxide poisoning. It was found out that to correct central nervous system functions disorders in case of acute damage by carbon monoxide, it is necessary to use agents possessing neuroprotective mechanisms of action. The review reports data on the effectiveness of hydrogenated solution, methane solution, allopurinol, erythropoietin, granulocyte colonystimulating factor, remifentanil, mesenchymal stem cells, cerebrolysin for correction of the central nervous system disorders in this type of pathology.

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The authors declare that there are no conflicts of interest present.