toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0869-7922-2023-31-2-83-88toxreview-688Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВзаимосвязь полиморфизмов генов семейства глутатион-S-трансфераз с различными заболеваниями (обзор зарубежной литературы)Association of glutathione-S-transferase gene polymorphisms with various disease (review of foreign studies)https://orcid.org/0000-0002-4109-9268БерёзаИван АндреевичBerezaIvan Andreevich

Научный сотрудник отдела молекулярной биологии и электронной микроскопии ФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Роспотребнадзора, 620014, г. Екатеринбург.

e-mail: ivan11011994@gmail.com

Researcher, Department of Molecular Biology and Electron Microscopy, FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russian Federation.

e-mail: ivan11011994@gmail.com

berezaia@ymrc.ruhttps://orcid.org/0000-0002-7029-3406ШаиховаДарья РамильевнаShaikhovaDaria Ramilevnadarya.boo@mail.ruhttps://orcid.org/0000-0001-8794-7288АмроминаАнна МихайловнаAmrominaAnna Mikhailovnaamrominaam@ymrc.ruФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияYekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of the Federal Service for Supervision of Consumer Rights Protection and Human Well-BeingRussian Federation2023270420233128388Copyright © Берёза И.А., Шаихова Д.Р., Амромина А.М., 20232023Берёза И.А., Шаихова Д.Р., Амромина А.М.Bereza I.A., Shaikhova D.R., Amromina A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/688Введение

Введение. Данный литературный обзор посвящён взаимосвязи полиморфизмов генов GSTM1, GSTT1, GSTP1 с различными заболеваниями, описанной в зарубежных источниках литературы.

Материалы и методы

Материалы и методы. Авторы использовали данные, опубликованные в зарубежной литературе за последние 11 лет. В базе данных Medline был проведён всесторонний поиск подходящих исследований с помощью поисковой системы Pubmed, и в итоге для включения в этот обзор были отобраны 30 исследований.

Результаты

Результаты. Этот обзор показал, что исследователи во всем мире неоднократно пытались оценить связь между полиморфизмами GST и различными заболеваниями, но в ряде случаев получали противоречивые результаты. В то же время во многих исследованиях была обнаружена ассоциация патологий как с отдельным полиморфизмом генов GST, так и с комбинированными полиморфными вариантами, что свидетельствует о комплексном действии генов антиоксидантной системы.

Несмотря на часто противоречивые данные разных исследователей, не вызывает сомнения, что полиморфизмы GSTM1, GSTT1 и GSTP1 имеют достоверную взаимосвязь со многими нарушениями, в результате снижения эффективности антиоксидантной системы и ее способности к детоксикации ксенобиотиков.

Ограничение исследования

Ограничение исследования. Ограничением данного обзора является отсутствие отечественных источников литературы.

Заключение

Заключение. Необходимы дальнейшие исследования влияния функциональных полиморфизмов генов семейства для разработки эффективных систем тестирования, профилактики и лечения заболеваний.

Соблюдение этических стандартов. Исследование не требует представления заключения комитета по биомедицинской этик.

Участие авторов

Участие авторов. Все соавторы внесли равнозначный вклад в исследование и подготовку статьи к публикации.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Поступила в редакцию

Поступила в редакцию: 20 января 2023 / Принята в печать: 02 февраля 2023 / Опубликована: 30 апреля 2023 

Introduction

Introduction. This review is devoted to the association of GSTM1, GSTT1, GSTP1 gene polymorphisms with various diseases in foreign literature sources.

Material and methods

Material and methods. For this article, we used data published in foreign literature over the past 11 years. medline was extensively searched for eligible studies using the Pubmed search engine, and 30 studies were eventually selected for inclusion in this review.

Results

Results. This review showed that researchers all over the world have repeatedly tried to evaluate the relationship between GST polymorphisms and various diseases, but in some cases received conflicting results. At the same time, many studies have found an association of pathologies with both single GST gene polymorphisms and combined polymorphic variants, which indicates a complex effect of antioxidant system genes.

Limitation of the study

Limitation of the study. The limitation of this review is the lack of domestic literary sources.

Conclusion

Conclusion. Further research of functional polymorphisms of the GST family genes are needed to develop effective systems for the diagnosis, prevention, and treatment of diseases.

Compliance with ethical standards. This study does not require the conclusion of a biomedical ethics committee or other documents.

Contribution

Contribution. All co-authors made an equal contribution to the research and preparation of the article for publication.

Conflict of interests

Conflict of interests. The authors declare no conflict of interest.

Funding

Funding. The study had no sponsorship.

Received

Received: January 1, 2023 / Accepted: February 2, 2023 / Published: April 30, 2023

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The authors declare that there are no conflicts of interest present.