toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0869-7922-2023-31-2-89-98toxreview-689Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРоль биологически активных средств в повышении устойчивости организма к токсическому действию наночастиц (обзор литературы)The role of bioactive agents in enhancing the defense response to nanoparticle toxicity (a literature review)https://orcid.org/0000-0003-2677-0479РябоваЮлия ВладимировнаRyabovaYulia Vladimirovna

Заведующая лабораторией научных основ биологической профилактики ФБУН ЕМНЦ ПОЗРПП Роспотребнадзора, 620014, Екатеринбург, Российская Федерация.

e-mail: ryabovaiuvl@gmail.com

Head of the Laboratory of Scientific Fundamentals of Biological Methods of Disease Prevention, Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Yekaterinburg, 620014, Russian Federation.

e-mail: ryabovaiuvl@gmail.com

ryabovaiuvl@gmail.comhttps://orcid.org/0000-0002-8284-0008ШабардинаЛада ВладимировнаShabardinaLada Vladimirovnalada.shabardina@mail.ruФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial WorkersRussian Federation2023270420233128998Copyright © Рябова Ю.В., Шабардина Л.В., 20232023Рябова Ю.В., Шабардина Л.В.Ryabova Y.V., Shabardina L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/689Введение

Введение. Необходимость повышения устойчивости организма человека к токсическому действию наночастиц (НЧ) обусловлена их широким распространением. Контакт человека с НЧ не ограничивается производственной деятельностью: он может произойти из-за загрязнения окружающей среды, либо ввиду их целенаправленного применения (например, в медицине и косметологии). Полное устранение экспозиции к НЧ и вредного действия на организм человека, обусловленного ею на данном этапе технологического развития, представляется невозможным, что делает проблему актуальной. 

Цель исследования — изучить возможности биологически активных средств (витаминов, макро- и микроэлементов, флавоноидов и др.) повышать устойчивость организма к действию НЧ. 

Материал и методы

Материал и методы. Проведён анализ и обобщение современных научных исследований. Поиск публикаций проводился по базам данных PubMed, Web of Science, GoogleScholar, а также российским научным электронным библиотекам eLibrary.ru и CyberLeninka. Отбор статей осуществлялся по принципу наличия в них сведений о негативном влиянии на организм НЧ (1–100 нм) и о снижении их токсичности с помощью биопротекторов, а объектом исследования являлись лабораторные животные. Было проанализировано более 70 статей, в результате из них отобран 31 полнотекстовой материал. 

Результаты

Результаты. Показана возможность биологически активных средств повышать устойчивость живого организма, в том числе теплокровных млекопитающих, к воздействию наночастиц. Обнаружено защитное действие витамина Е от нефротоксического действия НЧ золота (Au), токсического действия НЧ серебра (Ag); витамина С против гепатотоксического действия НЧ оксида титана (IV) (TiO2), репротоксичности НЧ никеля (Ni); витаминов группы В от токсичности, индуцированной НЧ оксида цинка (ZnO). В исследованиях показано протекторное действие селена от НЧ Ag, в том числе отмечены кардиопротекторные эффекты. Защитные эффекты от нефро-, нейро- и гепатотоксичности наночастиц показали флавоноиды (гесперидин, кверцетин). Кроме того, отмечена их положительная роль в восстановлении митохондриальной дисфункции. Аминокислота L-аргинин также проявила способность благотворно влиять на организм при интоксикации, индуцированной НЧ Au.

Ограничения исследования

Ограничения исследования. В обзор вошли материалы из открытых источников, опубликованных на русском и/или английском языках.

Заключение

Заключение. Представленный обзор литературы позволяет выявить наиболее эффективные способы повышения устойчивости живого организма к действию НЧ.

Соблюдение этических стандартов. Исследование не требует представления заключения комитета по биомедицинской этике.

Участие авторов

Участие авторов: Рябова Ю.В. — концепция и дизайн исследования, написание текста, редактирование; Шабардина Л.В. — сбор и обработка материала. Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи. 

Конфликт интересов

Конфликт интересов. авторы заявляют об отсутствии конфликта интересов.

Финансирование

Финансирование. Исследование выполнено за счёт бюджета ФБУН «Екатеринбургский медицинский – научный центр профилактики и охраны здоровья рабочих промпредприятий» Роспотребнадзора.

Поступила в редакцию

Поступила в редакцию: 20 января 2023 / Принята в печать: 02 февраля 2023 / Опубликована: 30 апреля 2023 

Introduction

Introduction. Ubiquity of nanoparticles (NPs) necessitates the increase in the resistance and tolerance of the human body to their toxic effects. The exposure to nanoparticles can occur not only in the occupational setting but also because of environmental pollution and a purposeful use of nanomaterials (e.g., in medicine and cosmetology). Impossibility of elimination of nanoparticle exposure and its adverse health effects at the current stage of technological development makes the problem even more urgent. Our objective was to study the ability of bioactive agents (vitamins, macro- and microelements, flavonoids, etc.) to enhance the defense response to nanoparticle toxicity. 

Material and methods

Material and methods. The analysis and generalization of modern scientific research is carried out. To review and summarize data of recent scientific studies, we have done a literature search using PubMed, Web of Science, and Google Scholar search engines, as well as Russian scientific electronic libraries eLibrary.ru and Cyberleninka.ru. The inclusion criteria were information about adverse health effects of nano-sized particles (1–100 nm) and attenuation of their toxicity using bioprotectors in experimental animals. After primary screening of more than 70 publications, we selected thirty-six articles for the review.

Results

Results. The ability of bioactive agents to increase the resistance of a living organism, including warm-blooded mammals, to nanoparticle exposure has been demonstrated. We established a protective effect of vitamin E against nephrotoxicity of gold NPs and toxicity of silver NPs; vitamin C against the hepatotoxic effect of titanium (IV) oxide NPs and reproductive toxicity of nickel NPs, and B vitamins against toxic effects of zinc oxide NPs. We have also found evidence of a protective effect of selenium against silver NPs, including cardioprotective ones. Flavonoids (hesperidin and quercetin) demonstrated protective effects against nephro-, neuro- and hepatotoxicity of nanoparticles. In addition, we noted their positive role in repair of mitochondrial dysfunction. L-arginine also showed the ability to attenuate poisoning induced by Au NPs.

Limitations of the study

Limitations of the study. We reviewed open access Russian and English-language publications.

Conclusion

Conclusion. This literature review facilitates identification of the most effective ways to increase the resistance and tolerance of a living organism to adverse health effects of nanoparticles.

Compliance with ethical standards. This study does not require the conclusion of a biomedical ethics committee or other documents.

Author Contribution

Author Contribution: Ryabova Yu.V. — study conception and design, draft manuscript preparation; Shabardina L.V. — data collection and processing. Both authors reviewed the results and approved the final version of the manuscript.

Conflict of interests

Conflict of interests. The authors declare no conflict of interest. 

Acknowledgements

Acknowledgements. the study was carried out at the expense of the budget of the Federal State Budgetary Institution "Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers" of Rospotrebnadzor.

Received

Received: January 16, 2023 / Accepted: February 9,2023 / Published: April 30, 2023

интоксикациянаночастицыбиологическая профилактикавитаминымикроэлементымакроэлементыобзорtoxicitynanoparticlesbiological preventionvitaminstrace elementsmacroelementsreviewReferencesManke A., Wang L., Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013; 2013: 942916. https://doi.org/10.1155/2013/942916Manke A., Wang L., Rojanasakul Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013; 2013: 942916. https://doi.org/10.1155/2013/942916Hedayati S.A., Farsani H.G., Naserabad S.S., Hoseinifar S.H., Van Doan H. Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2019; 222: 100–7. https://doi.org/10.1016/j.cbpc.2019.04.004Hedayati S.A., Farsani H.G., Naserabad S.S., Hoseinifar S.H., Van Doan H. Protective effect of dietary vitamin E on immunological and biochemical induction through silver nanoparticles (AgNPs) inclusion in diet and silver salt (AgNO3) exposure on Zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2019; 222: 100–7. https://doi.org/10.1016/j.cbpc.2019.04.004Bakr M.M., Al-Ankily M.M., Shogaa S.M., Shamel M. Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands. Bioengineering (Basel). 2021; 8(12): 219. https://doi.org/10.3390/bioengineering8120219Bakr M.M., Al-Ankily M.M., Shogaa S.M., Shamel M. Attenuating Effect of Vitamin E against Silver Nano Particles Toxicity in Submandibular Salivary Glands. Bioengineering (Basel). 2021; 8(12): 219. https://doi.org/10.3390/bioengineering8120219Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y.H., Ghannam M.M. The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. Int J Nanomedicine. 2020; 15: 729–34. https://doi.org/10.2147/IJN.S192740Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y.H., Ghannam M.M. The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. Int J Nanomedicine. 2020; 15: 729–34. https://doi.org/10.2147/IJN.S192740Baky N.A., Faddah L.M., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J. Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E. Drug Res (Stuttg). 2013; 63(5): 228–36. https://doi.org/10.1055/s-0033-1334923Baky N.A., Faddah L.M., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J. Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E. Drug Res (Stuttg). 2013; 63(5): 228–36. https://doi.org/10.1055/s-0033-1334923Kalender S., Kalender Y., Ogutcu A., Uzunhisarcikli M., Durak D., Açikgoz F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 2004; 202(3): 227–35. https://doi.org/10.1016/j.tox.2004.05.010Kalender S., Kalender Y., Ogutcu A., Uzunhisarcikli M., Durak D., Açikgoz F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 2004; 202(3): 227–35. https://doi.org/10.1016/j.tox.2004.05.010Hajirezaee S., Mohammadi G., Naserabad S.S. The protective effects of vitamin C on common carp (Cyprinus carpio) exposed to titanium oxide nanoparticles (TiO2-NPs). Aquaculture. 2020; 518: 734734. https://doi.org/10.1016/j.aquaculture.2019.734734Hajirezaee S., Mohammadi G., Naserabad S.S. The protective effects of vitamin C on common carp (Cyprinus carpio) exposed to titanium oxide nanoparticles (TiO2-NPs). Aquaculture. 2020; 518: 734734. https://doi.org/10.1016/j.aquaculture.2019.734734Taghyan S.A., Messiry H.E., Zainy M.A.E. Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: аn in vivo study. Toxicol Ind Health. 2020; 36(6): 446–53. https://doi.org/10.1177/0748233720933071Taghyan S.A., Messiry H.E., Zainy M.A.E. Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: аn in vivo study. Toxicol Ind Health. 2020; 36(6): 446–53. https://doi.org/10.1177/0748233720933071Kong L., Hu W., Lu C., Cheng K., Tang M.. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. 2019; 218: 259–65. https://doi.org/10.1016/j.chemosphere.2018.11.128Kong L., Hu W., Lu C., Cheng K., Tang M.. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. 2019; 218: 259–65. https://doi.org/10.1016/j.chemosphere.2018.11.128Hafez A.A., Naserzadeh P., Ashtari K., Mortazavian A.M., Salimi A. Protection of manganese oxide nanoparticles-induced liver and kidney damage by vitamin D. Regul Toxicol Pharmacol. 2018; 98: 240–4. https://doi.org/10.1016/j.yrtph.2018.08.005Hafez A.A., Naserzadeh P., Ashtari K., Mortazavian A.M., Salimi A. Protection of manganese oxide nanoparticles-induced liver and kidney damage by vitamin D. Regul Toxicol Pharmacol. 2018; 98: 240–4. https://doi.org/10.1016/j.yrtph.2018.08.005Yousef J.M., Mohamed A.M. Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers. Pak J Pharm Sci. 2015; 28(1): 175–84.Yousef J.M., Mohamed A.M. Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers. Pak J Pharm Sci. 2015; 28(1): 175–84.Ansar S., Abudawood M., Hamed S.S., Aleem M.M. Sodium selenite protects against silver nanoparticle-induced testicular toxicity and inflammation. Biol Trace Elem Res. 2017; 175(1): 161–8. https://doi.org/10.1007/s12011-016-0759-3Ansar S., Abudawood M., Hamed S.S., Aleem M.M. Sodium selenite protects against silver nanoparticle-induced testicular toxicity and inflammation. Biol Trace Elem Res. 2017; 175(1): 161–8. https://doi.org/10.1007/s12011-016-0759-3Ansar S., Alshehri S.M., Abudawood M., Hamed S.S., Ahamad T. Antioxidant and hepatoprotective role of selenium against silver nanoparticles. Int J Nanomedicine. 2017; 12: 7789–97. https://doi.org/10.2147/IJN.S136748Ansar S., Alshehri S.M., Abudawood M., Hamed S.S., Ahamad T. Antioxidant and hepatoprotective role of selenium against silver nanoparticles. Int J Nanomedicine. 2017; 12: 7789–97. https://doi.org/10.2147/IJN.S136748Ma W., He S., Ma H., Jiang H., Yan N., Zhu L., Bang J.J., Li P.A., Jia S. Silver nanoparticle exposure causes pulmonary structural damage and mitochondrial dynamic imbalance in the rat: protective effects of sodium selenite. Int J Nanomedicine. 2020; 15: 633–45. https://doi.org/10.2147/IJN.S232986Ma W., He S., Ma H., Jiang H., Yan N., Zhu L., Bang J.J., Li P.A., Jia S. Silver nanoparticle exposure causes pulmonary structural damage and mitochondrial dynamic imbalance in the rat: protective effects of sodium selenite. Int J Nanomedicine. 2020; 15: 633–45. https://doi.org/10.2147/IJN.S232986Ma W., He S., Xu Y., Qi G., Ma H., Bang J.J., Li P.A. Ameliorative effect of sodium selenite on silver nanoparticles-induced myocardiocyte structural alterations in rats. Int J Nanomedicine. 2020; 15: 8281–92. https://doi.org/10.2147/IJN.S271457Ma W., He S., Xu Y., Qi G., Ma H., Bang J.J., Li P.A. Ameliorative effect of sodium selenite on silver nanoparticles-induced myocardiocyte structural alterations in rats. Int J Nanomedicine. 2020; 15: 8281–92. https://doi.org/10.2147/IJN.S271457Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A.Y. The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. Int J Nanomedicine. 2018; 13: 2821–5. https://doi.org/10.2147/IJN.S160995Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A.Y. The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. Int J Nanomedicine. 2018; 13: 2821–5. https://doi.org/10.2147/IJN.S160995Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y., Al-Ayed M.S. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. Int J Nanomedicine. 2018; 13: 7765–70. https://doi.org/10.2147/IJN.S183281Abdelhalim M.A.K., Qaid H.A., Al-Mohy Y., Al-Ayed M.S. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. Int J Nanomedicine. 2018; 13: 7765–70. https://doi.org/10.2147/IJN.S183281Fadda L.M., Hagar H., Mohamed A.M., Ali H.M. Quercetin and idebenone ameliorate oxidative stress, inflammation, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in rat liver. Dose Response. 2018; 16(4). https://doi.org/10.1177/1559325818812188Fadda L.M., Hagar H., Mohamed A.M., Ali H.M. Quercetin and idebenone ameliorate oxidative stress, inflammation, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in rat liver. Dose Response. 2018; 16(4). https://doi.org/10.1177/1559325818812188Al-Rasheed N.M., Faddah L.M., Mohamed A.M., Abdel Baky N.A., Al-Rasheed N.M., Mohammad R.A. Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity. J Oleo Sci. 2013; 62(11): 961–71. https://doi.org/10.5650/jos.62.961Al-Rasheed N.M., Faddah L.M., Mohamed A.M., Abdel Baky N.A., Al-Rasheed N.M., Mohammad R.A. Potential impact of quercetin and idebenone against immuno- inflammatory and oxidative renal damage induced in rats by titanium dioxide nanoparticles toxicity. J Oleo Sci. 2013; 62(11): 961–71. https://doi.org/10.5650/jos.62.961Waseem M., Kaushik P., Dutta S., Chakraborty R., Hassan M.I., Parvez S. Modulatory role of quercetin in mitochondrial dysfunction in titanium dioxide nanoparticle-induced hepatotoxicity. ACS Omega. 2022; 7(4): 3192–202. https://doi.org/10.1021/acsomega.1c04740Waseem M., Kaushik P., Dutta S., Chakraborty R., Hassan M.I., Parvez S. Modulatory role of quercetin in mitochondrial dysfunction in titanium dioxide nanoparticle-induced hepatotoxicity. ACS Omega. 2022; 7(4): 3192–202. https://doi.org/10.1021/acsomega.1c04740Dora M.F., Taha N.M., Lebda M.A., Hashem A.E., Elfeky M.S., El-Sayed Y.S., Jaouni S.A., El-Far A.H. Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats. Int J Mol Sci. 2021; 22(8): 3829. https://doi.org/10.3390/ijms22083829Dora M.F., Taha N.M., Lebda M.A., Hashem A.E., Elfeky M.S., El-Sayed Y.S., Jaouni S.A., El-Far A.H. Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats. Int J Mol Sci. 2021; 22(8): 3829. https://doi.org/10.3390/ijms22083829Noshy P.A., Khalaf A.A.A., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Tammam A.A., Zaki A.R. Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin. Toxicology. 2022; 473: 153208. https://doi.org/10.1016/j.tox.2022.153208Noshy P.A., Khalaf A.A.A., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Tammam A.A., Zaki A.R. Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin. Toxicology. 2022; 473: 153208. https://doi.org/10.1016/j.tox.2022.153208Tammam A.A.-E., Khalaf A.A.А., Zaki A.R., Khalifa M.M., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Noshy P.A. Hesperidin protects rats’ liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles. Front Physiol. 2022; 13: 912625. https://doi.org/10.3389/fphys.2022.912625Tammam A.A.-E., Khalaf A.A.А., Zaki A.R., Khalifa M.M., Ibrahim M.A., Mekkawy A.M., Abdelrahman R.E., Farghali A., Noshy P.A. Hesperidin protects rats’ liver and kidney from oxidative damage and physiological disruption induced by nickel oxide nanoparticles. Front Physiol. 2022; 13: 912625. https://doi.org/10.3389/fphys.2022.912625Ansar S., Abudawood M., Alaraj A.S.A., Hamed S.S. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol Toxicol. 2018; 19(1): 65. https://doi.org/10.1186/s40360-018-0256-8Ansar S., Abudawood M., Alaraj A.S.A., Hamed S.S. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol Toxicol. 2018; 19(1): 65. https://doi.org/10.1186/s40360-018-0256-8Privalova L.I., Sutunkova M.P., Minigaliyeva I.A., Klinova S.V., Ryabova Iu.V., Solovyova S.N., Bushueva T.V., Fröhlich E., Shur V.Ya., Zubarev I.V., Makeyev O.H., Valamina I.E., Panov V.G., Shishkina E.V., Gurvich V.B., Katsnelson B.A. Experimental assessments of metallic and metal oxide nanoparticles’ toxicity. IOP Conf. Ser.: Mater. Sci. Eng. 2019; 699: 012037. https://doi.org/10.1088/1757-899X/699/1/012037Privalova L.I., Sutunkova M.P., Minigaliyeva I.A., Klinova S.V., Ryabova Iu.V., Solovyova S.N., Bushueva T.V., Fröhlich E., Shur V.Ya., Zubarev I.V., Makeyev O.H., Valamina I.E., Panov V.G., Shishkina E.V., Gurvich V.B., Katsnelson B.A. Experimental assessments of metallic and metal oxide nanoparticles’ toxicity. IOP Conf. Ser.: Mater. Sci. Eng. 2019; 699: 012037. https://doi.org/10.1088/1757-899X/699/1/012037Привалова Л.И., Рябова Ю.В., Сутункова М.П., Гурвич В.Б., Минигалиева И.А., Бушуева Т.В., Тажигулова А.В., Соловьева С.Н., Кацнельсон Б.А. Профилактика комбинированного цитотоксического действия наночастиц оксидов селена и меди в эксперименте. Здоровье населения и среда обитания – ЗНиСО. 2022; (9): 43–4. https://doi.org/10.35627/2219-5238/2022-30-9-43-48Privalova L.I., Ryabova Yu.V., Sutunkova M.P., Gurvich V.B., Minigalieva I.A., Bushueva T.V., Tazhigulova A.V., Solovyеva S.N., Katsnelson B.A. Prevention of the combined cytotoxic effect of selenium and copper oxide nanoparticles in the аnimal еxperiment. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2022; (9): 43–8. https://doi.org/10.35627/2219-5238/2022-30-9-43-48 (in Russian)Abdelazeim S.A., Shehata N.I., Aly H.F., Shams S.G.E. Amelioration of oxidative stress-mediated apoptosis in copper oxide nanoparticles-induced liver injury in rats by potent antioxidants. Sci Rep. 2020; 10(1): 10812. https://doi.org/10.1038/s41598-020-67784-yAbdelazeim S.A., Shehata N.I., Aly H.F., Shams S.G.E. Amelioration of oxidative stress-mediated apoptosis in copper oxide nanoparticles-induced liver injury in rats by potent antioxidants. Sci Rep. 2020; 10(1): 10812. https://doi.org/10.1038/s41598-020-67784-yFaddah L.M., Abdel Baky N.A., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J., Atteya M. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC Complement Altern Med. 2012; 12: 60. https://doi.org/10.1186/1472-6882-12-60Faddah L.M., Abdel Baky N.A., Al-Rasheed N.M., Al-Rasheed N.M., Fatani A.J., Atteya M. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC Complement Altern Med. 2012; 12: 60. https://doi.org/10.1186/1472-6882-12-60Moradi A., Ziamajidi N., Ghafourikhosroshahi A., Abbasalipourkabir R. Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats. Mol Biol Rep. 2019; 46(3): 2919–32. https://doi.org/10.1007/s11033-019-04752-4Moradi A., Ziamajidi N., Ghafourikhosroshahi A., Abbasalipourkabir R. Effects of vitamin A and vitamin E on attenuation of titanium dioxide nanoparticles-induced toxicity in the liver of male Wistar rats. Mol Biol Rep. 2019; 46(3): 2919–32. https://doi.org/10.1007/s11033-019-04752-4Afshari-Kaveh M., Abbasalipourkabir R., Nourian A., Ziamajidi N. The protective effects of vitamins a and e on titanium dioxide nanoparticles (nTiO2)-induced oxidative stress in the spleen tissues of male Wistar rats. Biol Trace Elem Res. 2021; 199(10): 3677–87. https://doi.org/10.1007/s12011-020-02487-zAfshari-Kaveh M., Abbasalipourkabir R., Nourian A., Ziamajidi N. The protective effects of vitamins a and e on titanium dioxide nanoparticles (nTiO2)-induced oxidative stress in the spleen tissues of male Wistar rats. Biol Trace Elem Res. 2021; 199(10): 3677–87. https://doi.org/10.1007/s12011-020-02487-zAbdelazim A.M., Saadeldin I.M., Swelum A.A., Afifi M.M., Alkaladi A. Oxidative stress in the muscles of the fish nile tilapia caused by zinc oxide nanoparticles and its modulation by vitamins C and E. Oxid Med Cell Longev. 2018; 2018: 6926712. https://doi.org/10.1155/2018/6926712Abdelazim A.M., Saadeldin I.M., Swelum A.A., Afifi M.M., Alkaladi A. Oxidative stress in the muscles of the fish nile tilapia caused by zinc oxide nanoparticles and its modulation by vitamins C and E. Oxid Med Cell Longev. 2018; 2018: 6926712. https://doi.org/10.1155/2018/6926712Alkaladi A. Vitamins E and C ameliorate the oxidative stresses induced by zinc oxide nanoparticles on liver and gills of Oreochromis niloticus. Saudi J Biol Sci. 2019; 26(2): 357–62. https://doi.org/10.1016/j.sjbs.2018.07.001Alkaladi A. Vitamins E and C ameliorate the oxidative stresses induced by zinc oxide nanoparticles on liver and gills of Oreochromis niloticus. Saudi J Biol Sci. 2019; 26(2): 357–62. https://doi.org/10.1016/j.sjbs.2018.07.001Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A., Al-Ayed M.S. Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles. Int J Nanomedicine. 2018; 13: 7931–8. https://doi.org/10.2147/IJN.S171931Abdelhalim M.A.K., Moussa S.A.A., Qaid H.A., Al-Ayed M.S. Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles. Int J Nanomedicine. 2018; 13: 7931–8. https://doi.org/10.2147/IJN.S171931Al-Rasheed N.M., Al-Rasheed N.M., Abdel Baky N.A., Faddah L.M., Fatani A.J., Hasan I.H., Mohamad R.A. Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat’s liver. Eur Rev Med Pharmacol Sci. 2014; 18(12): 1813–28.Al-Rasheed N.M., Al-Rasheed N.M., Abdel Baky N.A., Faddah L.M., Fatani A.J., Hasan I.H., Mohamad R.A. Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat’s liver. Eur Rev Med Pharmacol Sci. 2014; 18(12): 1813–28.Abdelkarem H.M., Fadda L.H., El-Sayed E.M., Radwan O.K. Potential role of L-arginine and vitamin E against bone loss induced by nano-zinc oxide in rats. J Diet Suppl. 2018; 15(3): 300–10. https://doi.org/10.1080/19390211.2017.1343889Abdelkarem H.M., Fadda L.H., El-Sayed E.M., Radwan O.K. Potential role of L-arginine and vitamin E against bone loss induced by nano-zinc oxide in rats. J Diet Suppl. 2018; 15(3): 300–10. https://doi.org/10.1080/19390211.2017.1343889Mohamed A.S., Soliman H.A., Ghannam H.E. Ameliorative effect of vitamins (E and C) on biochemical alterations induced by sublethal concentrations of zinc oxide bulk and nanoparticles in Oreochromis niloticus. Comp Biochem Physiol C Toxicol Pharmacol. 2021; 242: 108952. https://doi.org/10.1016/j.cbpc.2020.108952Mohamed A.S., Soliman H.A., Ghannam H.E. Ameliorative effect of vitamins (E and C) on biochemical alterations induced by sublethal concentrations of zinc oxide bulk and nanoparticles in Oreochromis niloticus. Comp Biochem Physiol C Toxicol Pharmacol. 2021; 242: 108952. https://doi.org/10.1016/j.cbpc.2020.108952

The authors declare that there are no conflicts of interest present.