toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2017-3-27-30toxreview-74Research ArticleСтатьиВЛИЯНИЕ ПОДОСТРОЙ ИНТОКСИКАЦИИ ЭТИЛЕНХЛОРГИДРИНОМ НА ИММУННЫЕ РЕАКЦИИ, ФУНКЦИЮ Th1- И Th2-ЛИМФОЦИТОВ И СОДЕРЖАНИЕ В КРОВИ КРЫС ЦИТОКИНОВTHE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOODЗабродскийП. Ф.ZabrodskiiP. F.noemail@neicon.ruМасляковВ. В.MaslyakovV. V.noemail@neicon.ruГромовМ. С.GromovM. S.noemail@neicon.ruФилиал НОУ ВПО «Саратовский медицинский университет “РЕАВИЗ”»РоссияBranch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”Russian Federation201728062017032730Copyright © Забродский П.Ф., Масляков В.В., Громов М.С., 20172017Забродский П.Ф., Масляков В.В., Громов М.С.Zabrodskii P.F., Maslyakov V.V., Gromov M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/74

В экспериментах на неинбредных белых крысах установлено, что подострое отравление этиленхлоргидрином (0,2 DL50 ежедневно в течение 4 сут) вызывает снижение функции Th1- и Th2-лимфоцитов в равной степени, уменьшение показателей гуморальных и клеточных иммунных реакций, содержания иммунорегуляторных цитокинов ИФН- , ИЛ-2, ИЛ-4 в крови и повышение концентраций провоспалительного цитокина ИЛ-6 и антивоспалительного цитокина ИЛ-10.

In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

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The authors declare that there are no conflicts of interest present.