toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.36946/0869-7922-2017-4-13-18toxreview-82Research ArticleСтатьиО СООТНОШЕНИИ МЕЖДУ ОБЩЕПРИНЯТОЙ ПРАКТИКОЙ ОЦЕНКИ РИСКА ДЛЯ ЗДОРОВЬЯ ПРИ ПОЛИМЕТАЛЛИЧЕСКИХ ЭКСПОЗИЦИЯХ И ТЕОРИЕЙ КОМБИНИРОВАННОЙ ТОКСИЧНОСТИCONCERNING COORDINATION BETWEEN THE GENERALLY ACCEPTED PRACTICE OF ASSESSING HEALTH RISKS DUE TO MULTI-METALLIC EXPOSURES AND THE THEORY OF COMBINED TOXICITYМинигалиеваИ. А.MinigalievaI. A.noemail@neicon.ruКацнельсонБ. А.KatsnelsonB. A.noemail@neicon.ruГурвичВ. Б.GurvichV. B.noemail@neicon.ruПриваловаЛ. И.PrivalovaL. I.noemail@neicon.ruПановВ. Г.PanovV. G.noemail@neicon.ruВараксинА. Н.VaraksinA. N.noemail@neicon.ruСутунковаМ. П.SutunkovaM. P.noemail@neicon.ruФБУН «Екатеринбургский медицинский - научный центр профилактики и охраны здоровья рабочих промпредприятий» РоспотребнадзораРоссияThe Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of RospotrebnadzorRussian FederationФБУН «Институт промышленной экологии» УрО РАНРоссияInstitute of Industrial Ecology, the Ural Branch of the Russian Academy of SciencesRussian Federation201728082017041318Copyright © Минигалиева И.А., Кацнельсон Б.А., Гурвич В.Б., Привалова Л.И., Панов В.Г., Вараксин А.Н., Сутункова М.П., 20172017Минигалиева И.А., Кацнельсон Б.А., Гурвич В.Б., Привалова Л.И., Панов В.Г., Вараксин А.Н., Сутункова М.П.Minigalieva I.A., Katsnelson B.A., Gurvich V.B., Privalova L.I., Panov V.G., Varaksin A.N., Sutunkova M.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/82

Хотя токсикология смесей является научной базой оценки кумулятивных рисков для здоровья, связанных с широко встречающимся комбинированным действием двух или более металлов и их соединений, однако, полного соответствия между ними нет, причём некоторые противоречия являются фундаментальными. Такое положение дел может быть объяснено не только упрощёнными подходами, характерными для методологии оценки риска, но и крайней сложностью теории комбинированной токсичности, основные аспекты которой авторы рассматривают на основе литературных и, главным образом, собственных ранее опубликованных данных.

Assessment of cumulative health risks associated with the widely observed combined effects of two or more metals and their compounds to the organism has the toxicology of mixtures as its scientific basis although there is no full match between such assessment and this basis though some of the contradictions between them are of a fundamental nature. This state of things may be explained not only by simplifications characteristic of the generally recognized methodology of risk assessment but also by extreme complexity of the theory of combined toxicity, the most essential issues of which are considered by authors on the basis of literary and, mostly, their own previously published data.

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The authors declare that there are no conflicts of interest present.