toxreviewТоксикологический вестникToxicological Review0869-79223034-4611Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0869-7922-2024-32-3-137-161bazawltoxreview-854Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESАнализ перспективных направлений совершенствования методической части системы биологического мониторинга на потенциально химически опасных объектах (аналитический обзор)Analysis of promising directions for improving the methodological part of the biological monitoring system at potentially hazardous chemical facilities (analytical review)https://orcid.org/0000-0002-2911-1260УколовАнтон ИгоревичUkolovAnton I.

Кандидат хим. наук, заведующий отделом токсикологии ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, Ленинградская область, Российская Федерация

Candidate of Chemical Sciences, Head of the Department of Toxicology of the Federal State Unitary Enterprise «Research Institute of Hygiene, Occupational Pathology and Human Ecology» FMBA of Russia, 188663, Leningrad Region, Russian Federation

e-mail: AntonUkolov@gmail.com

Scopus Author ID: 25321116600

Researcher ID: S-2545-2016

AntonUkolov@gmail.comhttps://orcid.org/0000-0003-0435-3228КомбароваМария ЮрьевнаKombarovaMariia Yu.

Кандидат мед. наук, заведующий отделом гигиены ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, Ленинградская область, Российская Федерация

Candidate of Medical Sciences, Head of the Department of Hygiene, of the Federal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia, 188663, Leningrad Region, Russian Federation

e-mail: Kombarova@gpech.ru

Kombarova@gpech.ruhttps://orcid.org/0000-0002-4472-6546РейнюкВладимир ЛеонидовичReiniukVladimir L.

Доктор мед. наук, профессор, врио директора ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация

Doctor of Medical Sciences, Professor, Acting Director of the Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”, 192019, St. Petersburg, Russian Federation

e-mail: info@toxicology.ru

SPIN-code: 5828-0337

Author ID: 162221

Scopus ID 9844286100

info@toxicology.ruhttps://orcid.org/0000-0002-3276-8036БариновВладимир АлександровичBarinovVladimir A.

Доктор мед. наук, профессор, ведущий научный сотрудник ФГБУ НКЦТ им. С.Н. Голикова ФМБА России, 192019, Санкт-Петербург, Российская Федерация

Doctor of Medical Sciences, Leading researcher of Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”, 192019, St. Petersburg, Russian Federation

e-mail: dissovet@toxicology.ru

SPIN-код: 3434-6341

Author ID: 788870

Scopus ID: 57191163581

dissovet@toxicology.ruhttps://orcid.org/0000-0003-0776-7434РадиловАндрей СтаниславовичRadilovAndrey S.

Доктор мед. наук, профессор, и.о. директора ФГУП «НИИ ГПЭЧ» ФМБА России, 188663, Ленинградская область, Российская Федерация

Doctor of Medical Sciences, Professor, Acting Director of the Federal State Unitary Enterprise «Research Institute of Hygiene, Occupational Pathology and Human Ecology» FMBA of Russia, 188663, Leningrad Region, Russian Federation

E-mail: radilov@gpech.ru

SPIN-code: 2081-5320

Author ID: 631675

Scopus ID 6507193049

radilov@gpech.ruФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» Федерального медико-биологического агентства; ФГБУ «Научно-клинический центр токсикологии имени академика С.Н. Голикова» Федерального медико-биологического агентстваРоссияFederal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of Russia; Federal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”Russian FederationФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» Федерального медико-биологического агентстваРоссияFederal State Unitary Enterprise “Research Institute of Hygiene, Occupational Pathology and Human Ecology” FMBA of RussiaRussian FederationФГБУ «Научно-клинический центр токсикологии имени академика С.Н. Голикова» Федерального медико-биологического агентстваРоссияFederal State Budgetary Institution “Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov of the FMBA of Russia”Russian Federation202427062024323137161Copyright © Уколов А.И., Комбарова М.Ю., Рейнюк В.Л., Баринов В.А., Радилов А.С., 20242024Уколов А.И., Комбарова М.Ю., Рейнюк В.Л., Баринов В.А., Радилов А.С.Ukolov A.I., Kombarova M.Y., Reiniuk V.L., Barinov V.A., Radilov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.toxreview.ru/jour/article/view/854Введение

Введение. В настоящее время в Российской Федерации в практике промышленной медицины не используются методы биологического мониторинга органических соединений — дополнения к производственному контролю, заключающегося в регулярном измерении содержания биомаркеров вредных химических веществ в организме работающих.

Цель исследования — анализ доступных научных публикаций и методических документов о биомаркерах вредных органических веществ, формирование выводов о направлениях развития методического обеспечения биологического мониторинга органических соединений в Российской Федерации.

Материал и методы

Материал и методы. Использованы доступные научные публикации, методические указания Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, материалы Федерального регистра потенциально опасных химических и биологических веществ (РПОХБВ) и зарубежные методические документы, в частности Агентства по токсичным веществам и регистру заболеваний (Agency for Toxic Substances and Disease Registry, США).

Результаты

Результаты. Собран перечень наиболее распространённых вредных органических веществ, обращающихся на опасных химических объектах, и их биомаркеров, методик их измерений в биологических средах. Выполнен анализ отечественных и зарубежных гигиенических нормативов содержания токсикантов или их маркеров в биологических средах.

Ограничения исследования

Ограничения исследования. Аналитический обзор методов биологического мониторинга выполнен только для органических соединений и не включает неорганические вещества.

Заключение

Заключение. Аналитический обзор позволил выявить следующие необходимые методические элементы для внедрения биологического мониторинга в Российской Федерации: разработка по меньшей мере 9 химико-аналитических методик определения биомаркеров в биологических средах работающих, внедрение иммунохроматографических методов при проведении биологического мониторинга работающих для уточнения достоверности данных анамнеза об отношении к алкоголю, табакокурению и лекарственным препаратам, экспериментальные исследования по обнаружению и идентификации биомаркеров экспозиции к ряду органических соединений, экспериментальное обоснование отсутствующих в СП 1.2.3685–21 гигиенических нормативов содержания в воздухе рабочей зоны 15 веществ.

Соблюдение этических стандартов. Исследование не требует представления заключения по биомедицинской этике.

Участие авторов

Участие авторов:Уколов А.И. — концепция и дизайн исследования, сбор и обработка материала, написание текста;Комбарова М.Ю. — сбор и обработка материала;Рейнюк В.Л., Баринов В.А., Радилов А.С. — редактирование.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Поступила в редакцию

Поступила в редакцию: 12.12.2023 / Принята в печать: 05.05.2024 / Опубликована: 28.06.2024

 

 

Introduction

Introduction. Currently in the Russian Federation, the practice of industrial medicine does not use methods of biological monitoring of organic compounds — an addition to industrial control, which consists in regularly measuring the content of biomarkers of harmful chemicals in the body of workers.

The purpose of the study is to analyze available scientific publications and methodological documents on biomarkers of harmful organic substances, to draw conclusions about the directions for the development of methodological support for biological monitoring of organic compounds in the Russian Federation.

Material and methods

Material and methods. available scientific publications, methodological guidelines of Rospotrebnadzor, materials of the Russian Register of Potentially Hazardous Chemical and Biological Substances, and foreign methodological documents, in particular from the Agency for Toxic Substances and Disease Registry, USA, were used.

Results

Results. A list of the most common harmful organic substances circulating at hazardous chemical facilities, their biomarkers and methods for measuring them in biological media was compiled. An analysis of domestic and foreign hygienic standards for the content of toxicants or their markers in biological media was performed.

Limitations

Limitations. The analytical review of biological monitoring methods was carried out only for organic compounds and does not include inorganic substances.

Conclusion

Conclusion. The analytical review made it possible to identify the following necessary methodological elements for the implementation of biological monitoring in the Russian Federation: the development of at least 9 chemical-analytical methods for determining biomarkers in the biological environments of workers, the introduction of immunochromatographic methods when conducting biological monitoring of workers to clarify the reliability of anamnesis data on attitudes towards alcohol, smoking and medications, experimental studies on the detection and identification of biomarkers of exposure to a number of organic compounds, experimental substantiation of hygienic standards for the content of 15 substances in the air of the working area.

Compliance with ethical standards. The study does not require the submission of a biomedical ethics report.

Authors contribution

Authors contribution:Ukolov A.I. — concept, collection and processing of material, writing text;Kombarova M.Yu. — collection and processing of material;Reynyuk V.L., Barinov V.A., Radilov A.S. — editing.All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest

Financing

Financing. The study had no sponsorship.

Received

Received: December 12, 2023 / Accepted: May 5, 2024 / Published: June 28, 2024

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The authors declare that there are no conflicts of interest present.