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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">toxreview</journal-id><journal-title-group><journal-title xml:lang="ru">Токсикологический вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Toxicological Review</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-7922</issn><issn pub-type="epub">3034-4611</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0869-7922-2025-33-2-108-115</article-id><article-id custom-type="edn" pub-id-type="custom">chcbdj</article-id><article-id custom-type="elpub" pub-id-type="custom">toxreview-964</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИЧЕСКАЯ ТОКСИКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTIVE TOXICOLOGY</subject></subj-group></article-categories><title-group><article-title>Химическая безопасность пищевых продуктов: новые вызовы и пути их решения (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Chemical safety of food products: problems and solutions (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9514-9921</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русаков</surname><given-names>Владимир Николаевич</given-names></name><name name-style="western" xml:lang="en"><surname>Rusakov</surname><given-names>Vladimir N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат мед. наук, ведущий научный сотрудник отдела гигиены питания ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Московская область, Россия</p><p>e-mail: rusakov.vn@fncg.ru</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Leading Researcher at the Food Hygiene Department, F.F. Erisman Federal Scientific Center of Hygiene, Rospotrebnadzor, 141014, Mytishchi, Russian Federation</p><p>e-mail: rusakov.vn@fncg.ru</p></bio><email xlink:type="simple">rusakov.vn@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6887-6776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сетко</surname><given-names>Андрей Геннадьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Setko</surname><given-names>Andrey G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, заведующий отделом гигиены питания ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Московская область, Россия</p><p>e-mail: Setko.AG@fncg.ru</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Head of the Food Hygiene Department, F.F. Erisman Federal Scientific Center of Hygiene, Rospotrebnadzor, 141014, Mytishchi, Russian Federation</p><p>e-mail: Setko.AG@fncg.ru</p></bio><email xlink:type="simple">Setko.AG@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8663-8475</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Немова</surname><given-names>Ольга Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Nemova</surname><given-names>Olga A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Младший научный сотрудник отдела гигиены питания ФБУН «ФНЦГ им. Ф.Ф. Эрисмана» Роспотребнадзора, 141014, Мытищи, Московская область, Россия</p><p>e-mail: nemova.oa@fncg.ru</p></bio><bio xml:lang="en"><p>Junior Researcher at the Food Hygiene Department, F.F. Erisman Federal Scientific Center of Hygiene, Rospotrebnadzor, 141014, Mytishchi, Russian Federation</p><p>e-mail: nemova.oa@fncg.ru</p></bio><email xlink:type="simple">nemova.oa@fncg.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр гигиены имени Ф.Ф. Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека</institution><country>Россия</country></aff><aff xml:lang="en"><institution>F.F. Erisman Federal Scientific Center of Hygiene, Rospotrebnadzor</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2025</year></pub-date><volume>33</volume><issue>2</issue><fpage>108</fpage><lpage>115</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Русаков В.Н., Сетко А.Г., Немова О.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Русаков В.Н., Сетко А.Г., Немова О.А.</copyright-holder><copyright-holder xml:lang="en">Rusakov V.N., Setko A.G., Nemova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.toxreview.ru/jour/article/view/964">https://www.toxreview.ru/jour/article/view/964</self-uri><abstract><sec><title>Введение</title><p>Введение. Химические загрязнители пищевой продукции, воздействуя на здоровье человека, являются серьезной проблемой здравоохранения. В то же время третья цель устойчивого развития Организации Объединённых Наций (ООН) направлена на существенное сокращение заболеваний, вызванных химическим загрязнением к 2030 г.</p><p>Цель исследования – анализ данных литературы для выявления приоритетных проблем загрязнения пищевой продукции химическими контаминантами и поиск путей решения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Изучены научные статьи и обзоры с использованием информационных порталов eLIBRARY.ru, Sciencedirect, PubMed и Scopus.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что к актуальным проблемам химической безопасности пищевых продуктов следует отнести их загрязнение остатками пестицидов, нитритами и нитратами, токсичными элементами, стойкими органическими загрязнителями, микотоксинами и фикотоксинами. Продукты миграции из тары и упаковки, а также микропластик по-прежнему являются источником загрязнения пищевых продуктов. Не потеряли своей актуальности проблемы фальсификации и выявления незаявленных в маркировке веществ.</p></sec><sec><title>Заключение</title><p>Заключение. Обеспечение химической безопасности пищевой продукции требует совершенствования нормативной и методической базы для оценки безопасности и контроля качества, что предусматривает мониторинг загрязнения пищевого сырья и пищевой продукции химическими контаминантами, оценку риска воздействия новых контаминантов и разработку высокочувствительных методов их обнаружения и идентификации, включая экспресс-тестирование.</p></sec><sec><title>Ограничения исследования</title><p>Ограничения исследования. Исследование ограничено изучением открытых литературных источников при описании проблем, связанных с химической безопасностью пищевых продуктов.</p><p>Соблюдение этических стандартов. Исследование не требует представления заключения комитета по биомедицинской этике или иных документов.</p></sec><sec><title>Участие авторов</title><p>Участие авторов: Русаков В.Н. – концепция и дизайн исследования, сбор материала и обработка данных, написание текста, редактирование; Сетко А.Г. – написание текста, редактирование; Немова О.А. – редактирование. Все соавторы – утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликтов интересов.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело финансовой поддержки.</p></sec><sec><title>Поступила в редакцию</title><p>Поступила в редакцию: 15 октября 2024 / Поступила после доработки: 28 февраля 2025 / Принята в печать: 28 февраля 2025 / Опубликована: 30 апреля 2025</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Chemical pollutants in food affect human health, which is becoming a very serious health problem and corresponds to the third UN Sustainable Development Goal, which aims to significantly reduce diseases caused by chemical pollution by 2030.</p><p>The purpose of the study was to identify, according to the scientific literature, priority problems of contamination of food products with chemical contaminants, which are currently of scientific and practical importance, and to outline ways to solve them.</p></sec><sec><title>Material and methods</title><p>Material and methods. A scientific review of studies in Russian and English was carried out using the information portals eLIBRARY.ru, Science Direct, PubMed and Scopus. The search was conducted using the keywords “current problems of chemical food safety”, “chemical contaminants of food”, “pesticides”, “nitrates”, “mycotoxins”, “persistent organic pollutants”, “phycotoxins”, “new food source”.</p></sec><sec><title>Results</title><p>Results. It has been established that the current problems of chemical safety of food products include their contamination with pesticide residues, nitrites and nitrates, mycotoxins, toxic elements, persistent organic pollutants. One of the problems is the detection and identification of emergent and modified (masked) mycotoxins. Seafood may contain dangerous substances – phycotoxins. Phycotoxins can cause both acute poisoning and long-term negative effects, including carcinogenic. Food packaging can also be a source of contamination of food products. Microplastics should be considered as a new growing contaminant of food products. The emergence of new types of food represents a modern problem of chemical safety. The problem of falsification and detection of substances not declared in the labeling is still relevant.</p></sec><sec><title>Conclusions</title><p>Conclusions. Ensuring the chemical safety of food products can be achieved by improving the regulatory and methodological framework for assessing the safety and quality control of food products. This also includes monitoring the contamination of food raw materials and food products with chemical contaminants, assessing the risk of exposure to new contaminants and developing highly sensitive methods for their detection and identification, including rapid testing.</p></sec><sec><title>Limitations</title><p>Limitations. The study is limited to the study of open literature sources when describing problems related to chemical safety of food products.</p><p>Compliance with ethical standards. The study does not require the submission of the conclusion of the biomedical ethics committee or other documents.</p></sec><sec><title>Аuthors’ сontribution</title><p>Аuthors’ сontribution: Rusakov V.N. – the concept and design of the study, collection and processing of material, writing text; editing; Setko A.G. – writing text; editing; Nemova O.A. – editing. All authors are responsible for the integrity of all parts of the manuscript and the approval of the final version of the article.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Funding</title><p>Funding. The study had no sponsorship.</p></sec><sec><title>Accepted</title><p>Accepted: October 15, 2024 / Revised: February 28, 2025 / Accepted: February 28, 2025 / Published: April 30, 2025</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>химические контаминанты</kwd><kwd>пестициды</kwd><kwd>микотоксины</kwd><kwd>химическая безопасность пищевых продуктов</kwd><kwd>фикотоксины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chemical contaminants</kwd><kwd>pesticides</kwd><kwd>mycotoxins</kwd><kwd>chemical food safety</kwd><kwd>phycotoxins</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад «О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2023 году». Доступно: https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT</mixed-citation><mixed-citation xml:lang="en">State report “On the sanitary-epidemiological well-being of the population in the Russian Federation in 2023”[Gosudarstvennyy doklad “O sostoyanii sanitarnо-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2023 godu]. URL: https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT _ID=27779 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Тареев А.И., Березнов А.В., Смирнов В.В., Тареева А.А., Кислая С.С. Мировой рынок химических средств защиты растений: потенциальные потери урожая, тренды и перспективы производства пестицидов для экономики России. Техника и технология пищевых производств. 2024; 54(2): 10–329. https://doi.org/10.21603/2074-9414-2024-2-2508</mixed-citation><mixed-citation xml:lang="en">Tareev A.I., Bereznov A.V., Smirnov V.V., Tareeva A.A., Kislaya S.S. World market of chemical plant protection products: potential crop losses, trends, and production prospects for the Russian economy [Mirovoy rynok khimicheskikh sredstv zashchity rasteniy: potentsial’nye poteri urozhaya, trendy i perspektivy proizvodstva pestitsidov dlya ekonomiki Rossii]. Tekhnika i tekhnologiya pishchevykh proizvodstv]. 2024; 54(2): 10–329. https://doi.org/10.21603/2074-9414-2024-2-2508 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kubiak-Hardiman P., Haughey S., Meneely J. Identifying gaps and challenges in global pesticide legislation that impact the protection of consumer health: rice as a case study. Exposure and Health. 2023; 15: 597–618. https://doi.org/10.1007/s12403-022-00508-x</mixed-citation><mixed-citation xml:lang="en">Kubiak-Hardiman P., Haughey S., Meneely J. Identifying gaps and challenges in global pesticide legislation that impact the protection of consumer health: rice as a case study. Exposure and Health. 2023; 15: 597–618. https://doi.org/10.1007/s12403-022-00508-x</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mishra P., Sharma A., Sharma D. A study on harmful effects of pesticide residue in vegetables. International Journal of Recent Research and Review. 2014; 7(1): 45–8.</mixed-citation><mixed-citation xml:lang="en">Mishra P., Sharma A., Sharma D. A study on harmful effects of pesticide residue in vegetables. International Journal of Recent Research and Review. 2014; 7(1): 45–8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">EFSA, Carrasco Cabrera L., Medina Pastor P. The 2020 European Union report on pesticide residues in food. EFSA Journal. 2022; 20(3): e07215. https://doi.org/10.2903/j.efsa.2022.7215</mixed-citation><mixed-citation xml:lang="en">EFSA, Carrasco Cabrera L., Medina Pastor P. The 2020 European Union report on pesticide residues in food. EFSA Journal. 2022; 20(3): e07215. https://doi.org/10.2903/j.efsa.2022.7215</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Reeves W.R., McGuire M.K., Stokes M., Vicini J.L. Assessing the safety of pesticides in food: how current regulations protect human health. Advances in Nutrition. 2019; 10(1): 80–8.</mixed-citation><mixed-citation xml:lang="en">Reeves W.R., McGuire M.K., Stokes M., Vicini J.L. Assessing the safety of pesticides in food: how current regulations protect human health. Advances in Nutrition. 2019; 10(1): 80–8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kori R.K., Singh M.K., Jain A.K., Yadav R.S. Neurochemical and behavioral dysfunctions in pesticide exposed farm workers: a clinical outcome. Indian Journal of Clinical Biochemistry. 2018; 33(4): 372–81. https://doi.org/10.1007/s12291-018-0791-5</mixed-citation><mixed-citation xml:lang="en">Kori R.K., Singh M.K., Jain A.K., Yadav R.S. Neurochemical and behavioral dysfunctions in pesticide exposed farm workers: a clinical outcome. Indian Journal of Clinical Biochemistry. 2018; 33(4): 372–81. https://doi.org/10.1007/s12291-018-0791-5</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bhargava N. et al. Advances in application of ultrasound in food processing: A review. Ultrasonics sonochemistry. 2021; 70: 105293. https://doi.org/10.1016/j.ultsonch.2020.105293</mixed-citation><mixed-citation xml:lang="en">Bhargava N. et al. Advances in application of ultrasound in food processing: A review. Ultrasonics sonochemistry. 2021; 70: 105293. https://doi.org/10.1016/j.ultsonch.2020.105293</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pandiselvam R., et al. Research trends and emerging physical processing technologies in mitigation of pesticide residues on various food products. Environ Sci Pollut Res Int. 2022; 29(30): 45131–49. https://doi.org/10.1007/s11356-022-20338-3</mixed-citation><mixed-citation xml:lang="en">Pandiselvam R., et al. Research trends and emerging physical processing technologies in mitigation of pesticide residues on various food products. Environ Sci Pollut Res Int. 2022; 29(30): 45131–49. https://doi.org/10.1007/s11356-022-20338-3</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Karwowska M., Kononiuk A. Nitrates/Nitrites in Food-Risk for Nitrosative Stress and Benefits. Antioxidants. 2020; 9(3): 241. https://doi.org/10.3390/antiox9030241</mixed-citation><mixed-citation xml:lang="en">Karwowska M., Kononiuk A. Nitrates/Nitrites in Food-Risk for Nitrosative Stress and Benefits. Antioxidants. 2020; 9(3): 241. https://doi.org/10.3390/antiox9030241</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ward M.H., et al. Drinking water nitrate and human health: an updated review. International journal of environmental research and public health. 2018; 15(7): 1557.</mixed-citation><mixed-citation xml:lang="en">Ward M.H., et al. Drinking water nitrate and human health: an updated review. International journal of environmental research and public health. 2018; 15(7): 1557.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S., Anil A.G., Kumar V., Kapoor D., Subramanian S., Singh J., Ramamurthy P.C. Nitrates in the environment: A critical review of their distribution, sensing techniques, ecological effects and remediation. Chemosphere. 2022 Jan; 287(1): 131996. https://doi.org/10.1016/j.chemosphere.2021.131996</mixed-citation><mixed-citation xml:lang="en">Singh S., Anil A.G., Kumar V., Kapoor D., Subramanian S., Singh J., Ramamurthy P.C. Nitrates in the environment: A critical review of their distribution, sensing techniques, ecological effects and remediation. Chemosphere. 2022 Jan; 287(1): 131996. https://doi.org/10.1016/j.chemosphere.2021.131996</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Тихонова Ю.Л., Милушкина О.Ю., Калиновская М.В., Симкалова Л.М. Сравнительный анализ химического загрязнения продуктов питания и показателей здоровья детского населения в Российской Федерации. Здоровье населения и среда обитания. 2020; (1): 13–8. https://doi.org/10.35627/2219-5238/2020-322-1-13-18</mixed-citation><mixed-citation xml:lang="en">Tikhonova Y.L., Milushkina O.Y., Kalinovskaya M.V., Simkalova L.M. Comparative analysis of chemical contamination of food products and health indicators of the child population in the Russian Federation. Zdorov’e naseleniya i sreda obitaniya. 2020; (1): 13–8. https://doi.org/10.35627/2219-5238/2020-322-1-13-18 (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fromme H., Körner W., Shahin N., Wanner A., Albrecht M., Boehmer S., Parlar H., Mayer R., Liebl B., Bolte G. Human exposure to polybrominated diphenyl ethers (PBDE), as evidenced by data from a duplicate diet study, indoor air, house dust, and biomonitoring in Germany. Environment International. 2009; 35(8): 1125–35.</mixed-citation><mixed-citation xml:lang="en">Fromme H., Körner W., Shahin N., Wanner A., Albrecht M., Boehmer S., Parlar H., Mayer R., Liebl B., Bolte G. Human exposure to polybrominated diphenyl ethers (PBDE), as evidenced by data from a duplicate diet study, indoor air, house dust, and biomonitoring in Germany. Environment International. 2009; 35(8): 1125–35.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cruz R., Cunha S.C., Casal S. Brominated flame retardants and seafood safety: a review. Environment international. 2015; 77: 116–31.</mixed-citation><mixed-citation xml:lang="en">Cruz R., Cunha S.C., Casal S. Brominated flame retardants and seafood safety: a review. Environment international. 2015; 77: 116–31.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y., Wang Y., Li J., Zhao Y., Guo F., Liu J., Cai Z. Perfluorinated compounds in seafood from coastal areas in China. Environment International. 2012; 42: 67–71.</mixed-citation><mixed-citation xml:lang="en">Wu Y., Wang Y., Li J., Zhao Y., Guo F., Liu J., Cai Z. Perfluorinated compounds in seafood from coastal areas in China. Environment International. 2012; 42: 67–71.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">EFSA. Bisphenol A: EFSA draft opinion proposes lowering the tolerable daily intake. ESFA J. 2021.</mixed-citation><mixed-citation xml:lang="en">EFSA. Bisphenol A: EFSA draft opinion proposes lowering the tolerable daily intake. ESFA J. 2021.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kwon J., et al. Microplastics in Food: A Review on Analytical Methods and Challenges. Int. J. Environ. Res. Public Health. 2020; 17: 6710.</mixed-citation><mixed-citation xml:lang="en">Kwon J., et al. Microplastics in Food: A Review on Analytical Methods and Challenges. Int. J. Environ. Res. Public Health. 2020; 17: 6710.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cho Y., Shim W.J., Jang M., Han G.M., Hong S.H. Abundance and characteristics of microplastics in market bivalves from South Korea. Environ. Pollut. 2019; 245: 1107–16.</mixed-citation><mixed-citation xml:lang="en">Cho Y., Shim W.J., Jang M., Han G.M., Hong S.H. Abundance and characteristics of microplastics in market bivalves from South Korea. Environ. Pollut. 2019; 245: 1107–16.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Koelmans A.A., Mohamed Nor N.H., Hermsen E., Kooi M., Mintenig S.M., De France J. Microplastics in freshwaters and drinking water: Critical review and assessment of data quality. Water Res. 2019; 155: 410–22.</mixed-citation><mixed-citation xml:lang="en">Koelmans A.A., Mohamed Nor N.H., Hermsen E., Kooi M., Mintenig S.M., De France J. Microplastics in freshwaters and drinking water: Critical review and assessment of data quality. Water Res. 2019; 155: 410–22.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bai C., Liu L., Hu Y., Zeng E.Y., Guo Y. Microplastics: A review of analytical methods, occurrence and characteristics in food, and potential toxicities to biota. Sci. Total Environ. 2022; 806: 150263.</mixed-citation><mixed-citation xml:lang="en">Bai C., Liu L., Hu Y., Zeng E.Y., Guo Y. Microplastics: A review of analytical methods, occurrence and characteristics in food, and potential toxicities to biota. Sci. Total Environ. 2022; 806: 150263.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Usman S., Abdull Razis A.F., Shaari K. Microplastics Pollution as an Invisible Potential Threat to Food Safety and Security, Policy Challenges and the Way Forward. Int. J. Environ. Res. Public Health. 2020; 17: 9591.</mixed-citation><mixed-citation xml:lang="en">Usman S., Abdull Razis A.F., Shaari K. Microplastics Pollution as an Invisible Potential Threat to Food Safety and Security, Policy Challenges and the Way Forward. Int. J. Environ. Res. Public Health. 2020; 17: 9591.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Alimba C.G., Faggio C. Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile. Environ. Toxicol. Pharmacol. 2019; 68: 61–74.</mixed-citation><mixed-citation xml:lang="en">Alimba C.G., Faggio C. Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile. Environ. Toxicol. Pharmacol. 2019; 68: 61–74.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ercili-Cura D., Häkämies A., Sinisalo L., et al. Food out of thin air. Food Sci. Tech. 2020; 2: 44–8. https://doi.org/10.1002/fsat.3402_12.x</mixed-citation><mixed-citation xml:lang="en">Ercili-Cura D., Häkämies A., Sinisalo L., et al. Food out of thin air. Food Sci. Tech. 2020; 2: 44–8. https://doi.org/10.1002/fsat.3402_12.x</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Eskola M., et al. Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited ‘FAO estimate’of 25%. Critical reviews in food science and nutrition. 2020; 60(16): 2773–89.</mixed-citation><mixed-citation xml:lang="en">Eskola M., et al. Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited ‘FAO estimate’of 25%. Critical reviews in food science and nutrition. 2020; 60(16): 2773–89.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kebede H., et al. Current status of major mycotoxins contamination in food and feed in Africa. Food Control. 2020; 110: 106975.</mixed-citation><mixed-citation xml:lang="en">Kebede H., et al. Current status of major mycotoxins contamination in food and feed in Africa. Food Control. 2020; 110: 106975.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Чернова А.В., Петроченкова А.В., Демиденко Е.О. Исследование проблемы контаминации пищевых продуктов токсигенными микотоксинами. Научные труды Дальрыбвтуза. 2023; 63(1): 28–35.</mixed-citation><mixed-citation xml:lang="en">Chernova A.V., Petrochenkova A.V., Demidenko E.O. Study of the contamination of food products with toxigenic mycotoxins. Nauchnye trudy Dalrybvtuz. 2023; 63(1): 28–35. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">COT. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment. Statement on the Potential Risk(s) of Combined Exposure to Mycotoxins. COT Statement. 2021. Available at: https://cot.food.gov.uk/sites/default/files/2021-10/COT%20statement%20combined%20exposure%20to%20mycotoxins%20technical_final_0.pdf</mixed-citation><mixed-citation xml:lang="en">COT. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment. Statement on the Potential Risk(s) of Combined Exposure to Mycotoxins. COT Statement. 2021. Available at: https://cot.food.gov.uk/sites/default/files/2021-10/COT%20statement%20combined%20exposure%20to%20mycotoxins%20technical_final_0.pdf</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Berthiller F., et al. Formation, determination and significance of masked and other conjugated mycotoxins. Analytical and Bioanalytical Chemistry. 2009; 395: 1243–52.</mixed-citation><mixed-citation xml:lang="en">Berthiller F., et al. Formation, determination and significance of masked and other conjugated mycotoxins. Analytical and Bioanalytical Chemistry. 2009; 395: 1243–52.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Freire L., Sant’Ana A. S. Modified mycotoxins: An updated review on their formation, detection, occurrence, and toxic effects. Food and Chemical Toxicology. 2018; 111: 189–205.</mixed-citation><mixed-citation xml:lang="en">Freire L., Sant’Ana A. S. Modified mycotoxins: An updated review on their formation, detection, occurrence, and toxic effects. Food and Chemical Toxicology. 2018; 111: 189–205.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Giannioti Z., et al. Determination of regulated and emerging mycotoxins in organic and conventional gluten-free flours by LC-MS/MS. Toxins. 2023; 15 (2): 155.</mixed-citation><mixed-citation xml:lang="en">Giannioti Z., et al. Determination of regulated and emerging mycotoxins in organic and conventional gluten-free flours by LC-MS/MS. Toxins. 2023; 15 (2): 155.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gruber-Dorninger C., Novak B., Nagl V., Berthiller F. Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants. J Agric Food Chem. 2017 Aug. 23; 65(33): 7052–70. https://doi.org/ 10.1021/acs.jafc.6b03413</mixed-citation><mixed-citation xml:lang="en">Gruber-Dorninger C., Novak B., Nagl V., Berthiller F. Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants. J Agric Food Chem. 2017 Aug. 23; 65(33): 7052–70. https://doi.org/ 10.1021/acs.jafc.6b03413</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Agriopoulou S., Stamatelopoulou E., Varzakas T. Advances in Analysis and Detection of Major Mycotoxins in Foods. Foods. 2020 Apr 20; 9(4): 518. https://doi.org/10.3390/foods9040518</mixed-citation><mixed-citation xml:lang="en">Agriopoulou S., Stamatelopoulou E., Varzakas T. Advances in Analysis and Detection of Major Mycotoxins in Foods. Foods. 2020 Apr 20; 9(4): 518. https://doi.org/10.3390/foods9040518</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Farabegoli F., Blanco L., Rodríguez L.P., Vieites J.M., Cabado A.G. Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans. Marine Drugs. 2018; 16(6): 188. https://doi.org/10.3390/md16060188</mixed-citation><mixed-citation xml:lang="en">Farabegoli F., Blanco L., Rodríguez L.P., Vieites J.M., Cabado A.G. Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans. Marine Drugs. 2018; 16(6): 188. https://doi.org/10.3390/md16060188</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nielsen L.T., et al. Accumulation, transformation and breakdown of DSP toxins from the toxic dinoflagellate Dinophysis acuta in blue mussels, Mytilus edulis. Toxicon. 2016; 117: 84–93.</mixed-citation><mixed-citation xml:lang="en">Nielsen L.T., et al. Accumulation, transformation and breakdown of DSP toxins from the toxic dinoflagellate Dinophysis acuta in blue mussels, Mytilus edulis. Toxicon. 2016; 117: 84–93.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Munday R., Reeve J. Risk assessment of shellfish toxins. Toxins. 2013; 5(11): 2109–37.</mixed-citation><mixed-citation xml:lang="en">Munday R., Reeve J. Risk assessment of shellfish toxins. Toxins. 2013; 5(11): 2109–37.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Seah J.S., Singh S., Tan L.P., Choudhury D. Scaffolds for the manufacture of cultured meat. Critical reviews in biotechnology. 2022 Feb 17; 42(2): 311–23. https://doi.org/10.1080/07388551.2021.1931803</mixed-citation><mixed-citation xml:lang="en">Seah J.S., Singh S., Tan L.P., Choudhury D. Scaffolds for the manufacture of cultured meat. Critical reviews in biotechnology. 2022 Feb 17; 42(2): 311–23. https://doi.org/10.1080/07388551.2021.1931803</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nicoletti R., Andolfi A., Becchimanzi A., Salvatore M.M. Anti-insect properties of Penicillium secondary metabolites. Microorganisms. 2023 May 16; 11(5): 1302. https://www.mdpi.com/2076-2607/11/5/1302</mixed-citation><mixed-citation xml:lang="en">Nicoletti R., Andolfi A., Becchimanzi A., Salvatore M.M. Anti-insect properties of Penicillium secondary metabolites. Microorganisms. 2023 May 16; 11(5): 1302. https://www.mdpi.com/2076-2607/11/5/1302</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Food and Agriculture Organization of the United Nations (FAO) &amp; World Health Organization (WHO). New food sources and production systems: Need for Codex attention and guidance? 2021. FAO; WHO. https://www.fao.org/fao-who-codexalimentarius/sh-proxy/jp/?lnk=1&amp;url=</mixed-citation><mixed-citation xml:lang="en">Food and Agriculture Organization of the United Nations (FAO) &amp; World Health Organization (WHO). New food sources and production systems: Need for Codex attention and guidance? 2021. FAO; WHO. https://www.fao.org/fao-who-codexalimentarius/sh-proxy/jp/?lnk=1&amp;url=</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Poma G., Fujii Y., Lievens S., Bombeke J., Gao B., Jeong Y., McGrath T.J., Covaci A. Occurrence, patterns, and sources of hazardous organic chemicals in edible insects and insect-based food from the Japanese market. Food and Chemical Toxicology. 2021 Aug 1; 154: 112311. https://doi.org/10.1016/j.fct.2021.112311</mixed-citation><mixed-citation xml:lang="en">Poma G., Fujii Y., Lievens S., Bombeke J., Gao B., Jeong Y., McGrath T.J., Covaci A. Occurrence, patterns, and sources of hazardous organic chemicals in edible insects and insect-based food from the Japanese market. Food and Chemical Toxicology. 2021 Aug 1; 154: 112311. https://doi.org/10.1016/j.fct.2021.112311</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Ghosh S., Rusyn I., Dmytruk O.V., Dmytruk K.V., Onyeaka H., Gryzenhout M., Gafforov Y. Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons. Frontiers in Bioengineering and Biotechnology. 2023 Feb 14; 11: 1106973. https://doi.org/10.3389/fbioe.2023.1106973</mixed-citation><mixed-citation xml:lang="en">Ghosh S., Rusyn I., Dmytruk O.V., Dmytruk K.V., Onyeaka H., Gryzenhout M., Gafforov Y. Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons. Frontiers in Bioengineering and Biotechnology. 2023 Feb 14; 11: 1106973. https://doi.org/10.3389/fbioe.2023.1106973</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Leong Y.K., Chang J.S. Bioremediation of heavy metals using microalgae: recent advances and mechanisms. Bioresource technology. 2020 May 1; 303:122886. https://doi.org/10.1016/j.biortech.2020.122886</mixed-citation><mixed-citation xml:lang="en">Leong Y.K., Chang J.S. Bioremediation of heavy metals using microalgae: recent advances and mechanisms. Bioresource technology. 2020 May 1; 303:122886. https://doi.org/10.1016/j.biortech.2020.122886</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад «Защита прав потребителей в Российской Федерации в 2022 году». Роспотребнадзор. https://www.rospotrebnadzor.ru/documents/details.php? ELEMENT_ID=25077</mixed-citation><mixed-citation xml:lang="en">State Report “Consumer Rights Protection in the Russian Federation in 2022”/ Rospotrebnadzor [Gosudarstvenny`j doklad «Zashhita prav potrebitelej v Rossijskoj Federacii v 2022 godu»/ Rospotrebnadzor]. URL: https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=25077 (in Russian)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
