TOXIC PULMONARY EDEMA BY INHALATION OF PYROLYSIS PRODUCTS OF CHLORINATED PARAFFIN-70 IN RATS
https://doi.org/10.36946/0869-7922-2018-6-8-11
Abstract
In the study conducted on laboratory animals (rats) toxic pulmonary edema (TPE) was simulated by inhalation of pyrolysis products of chlorinated paraffin-70 (CP-70). The average-lethal dose of CP-70 burned at 280 ÷ 350 ° C for 3 minutes is 8.1 ± 0.9 g and provides a concentration of hydrogen chloride (HCl) in the chamber at the level of 7325 [5850; 8460] ppm. Under these conditions exposure for 30 minutes led to an increase in the pulmonary rate (LC) in laboratory animals 24 hours after poisoning. The diagnosis of TPE was confirmed histologically by the signs of interstitial and alveolar edema, as well as arterial hypoxemia (TI = 204.5 [180; 228]) indicating respiratory failure. The death of animals was recorded 3 days after application of the pyrolysis products of CP-70. The simulated experimental TPE model can be used to search for the means of pathogenetic therapy of pulmonary toxicants poisoning.
About the Authors
P. G. Tolkach
S.M. Kirov Military Medical Academy, RF Ministry of Defense.
Russian Federation
194044, Saint-Petersburg.
Russian Federation
194044, Saint-Petersburg.
V. A. Basharin
S.M. Kirov Military Medical Academy, RF Ministry of Defense.
Russian Federation
194044, Saint-Petersburg.
Russian Federation
194044, Saint-Petersburg.
S. V. Chepur
State Scientific Research Institute of the Military Medicine.
Russian Federation
195043, Saint-Petersburg, Russian Federation.
Russian Federation
195043, Saint-Petersburg, Russian Federation.
References
1. Madorskij S. The thermal decomposition of organicpolymers : per. s. angl. / pod. red. S.R. Rafikova. – M.:Mir. 19(in Russian).
2. Polozova E.V., Shilov V.V., Shlyk I.V. Dynamics of morphological changes of the three-archonchial tree in patients with acute carbon monoxide poisoning with an especial thermal injury of the respiratory tract. Medicina truda i promyshlennaya ekologiya. 2015; (2): 12-(in Russian).
3. Torkunov P.A., Shabanov P.D. Pulmonary edema: pathogenesis, modeling, methodology for studying // Obzory po klincheskoj farmakologii i lekarstvennoj terapii. 2009; 6 (2): 3-(in Russian).
4. Chepur S.V., Bykov V.N., Yudiin M.A, Nikiforov A.S., Fateev I.V., Arutyunyan A.A. The features of experimental modeling of somatic and neurological diseases for evaluation of the effectiveness of drugs // Biomedicine. 2012; 1 (1): 16-(in Russian).
5. White C.V., Martin J.G. Chlorine gas inhalation: human clinical evidence of toxicity an experience in animal. Proceeding of the American thoracic society. 2010; 7 (4): 257-63.
6. De Lange D.W., Meulenbelt J. Do corticosteroids have a role in preventing or reducing acute toxic lung injury caused by inhalation of chemical agents? Clinical Toxicology. 2011; 49: 61-71.
7. Alarie Y. Toxicity of fire smoke. Critical review toxicology. 2002; 32 (4): 259-89.
8. Moroz V.V., Golubev A.M., Kuzovlev A.N. Pulmonary edema: klassification, mechanism of development, diagnosis // Obshchaya reanimatologiya. 2009; 1: 83-(in Russian).
Review
For citations:
Tolkach P.G., Basharin V.A., Chepur S.V. TOXIC PULMONARY EDEMA BY INHALATION OF PYROLYSIS PRODUCTS OF CHLORINATED PARAFFIN-70 IN RATS. Toxicological Review. 2018;(6):8-11. (In Russ.) https://doi.org/10.36946/0869-7922-2018-6-8-11
Views:
857
Email this article 