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ACUTE TOXICITY OF THE MINERAL COMPLEX BASED ON NANOPOWDERS OF IRON, COPPER AND ZINC AFTER A SINGLE INTRAPERITONEAL INJECTION

https://doi.org/10.36946/0869-7922-2018-6-22-24

Abstract

An injection form of the mineral complex consisting of a mixture of iron, zinc and copper nanopowders has been proposed. According to the results of studies the injection form of the drug based on metal nanopowders belongs to the V-VI class of practically non-toxic, relatively harmless drugs by Hodge and to the 5th class of toxicity in accordance with GOST 32644-2014. 

About the Authors

E. Yu. Andreeva
N.I. Vavilov Saratov State Agrarian University.
Russian Federation
410012, Saratov.


T. N. Rodionova
N.I. Vavilov Saratov State Agrarian University.
Russian Federation
410012, Saratov.


D. V. Gorbunov
Institute of Toxicology of the Federal Medical and Biological Agency.
Russian Federation
192019, Saint-Petersburg.


M. P. Marinicheva
N.I. Vavilov Saratov State Agrarian University.
Russian Federation
410012, Saratov.


References

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3. Guidelines for conducting preclinical studies of drugs. Part one. Edited by Mironov A.N. - M .: Grief and K, 20- 944 p. (in Russian)

4. GOST 32644-2014 Test methods for the effects of chemical products on the human body. Acute oral toxicity - method for determining the class of acute toxicity, 2015. (in Russian)

5. Reznichenko L.S., Dybkova S.N., Doroshenko A.M., Chekmani I.S., Ulberg Z.R. Synthesis of iron nanoparticles and characterization of their biosafety. Bulletin of problems of biology and medicine. 2014; 3 (2): 319-323. (in Russian)

6. Prozorovsky V.B. Statistical processing of pharmacological research results. Psychopharmacology and biological narcology. 207 (3): 2090-2120. (in Russian


Review

For citations:


Andreeva E.Yu., Rodionova T.N., Gorbunov D.V., Marinicheva M.P. ACUTE TOXICITY OF THE MINERAL COMPLEX BASED ON NANOPOWDERS OF IRON, COPPER AND ZINC AFTER A SINGLE INTRAPERITONEAL INJECTION. Toxicological Review. 2018;(6):22-24. (In Russ.) https://doi.org/10.36946/0869-7922-2018-6-22-24

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ISSN 0869-7922 (Print)