DOMESTIC ANTITUMOR COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3- PROPANEDIOL (CHLONISOL). ACUTE TOXICITY
https://doi.org/10.36946/0869-7922-2020-6-49-53
Abstract
2-[3-(2-Chloroethyl)-3-nitrosoureido]-1,3-propanediol (Сhlonisol) is a representative of a separate group of derivatives of the class of nitrosoalkylureas – alkylnitrosoureidopropanediols, which are characterized by high antitumor activity on a wide range of experimental tumors. Chlonisol LD50 in male mice for intravenous administration was 35 mg/kg, intraperitoneal – 39 mg/kg, in female mice – 34 mg/kg and 36 mg/kg, respectively. In rats of males with intraperitoneal administration, LD50 was 30 mg/kg, in rats of females – 32 mg/kg. The maximum tolerated dose in mice, rats, guinea pigs and rabbits was 20 mg/kg. The tolerated dose for dogs was a dose of 2 mg/kg. Myelo-depression was a dose-limiting side effect. Lethal and sublethal doses of Chlonisol caused aplasia of the bone marrow and lymphoid organs, damage to the mucous membrane of the gastrointestinal tract, and dystrophic changes in the myocardium, lungs, liver, kidneys, pancreas, and reproductive organs. In the late stages after intraperitoneal administration of sublethal doses of Chlonisol, chylothorax and chyloperitoneum were found in some rats.
About the Authors
A. N. Stukov
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Stukov Alexander Nikolaevich
197758, Saint Petersburg
S. F. Vershinina
A.M. Granov Russian Research Center for Radiology and Surgical Technologies, RF Ministry of Health
Russian Federation
Russian Federation
Vershinina Sofia Fathutdinovna
197758, Saint Petersburg
N. N. Kharitonova
S.M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Kharitonova Natalja Nicolaevna
194044, Saint Petersburg
L. V. Filatova
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Filatova Larisa Valentinovna
197758, Saint Petersburg
D. Н. Latipova
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Latipova Dilorom Hamidovna
197758, Saint Petersburg
M. L. Tyndyk
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Tyndyk Margarita Leonidovna
197758, Saint Petersburg
Yu. G. Zmitrichenko
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Zmitrichenko Yuliya Gennadievna
197758, Saint Petersburg
A. L. Semenov
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Semenov Alexander Leonidovich
197758, Saint Petersburg
V. G. Bespalov
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Bespalov Vladimir Grigorievich
197758, Saint Petersburg
T. Yu. Semiglazova
N.N. Petrov Scientifi c Research Center of Oncology, RF Ministry of Health
Russian Federation
Russian Federation
Semiglazova Tatiana Yuryevna
197758, Saint Petersburg
References
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Review
For citations:
Stukov A.N., Vershinina S.F., Kharitonova N.N., Filatova L.V., Latipova D.Н., Tyndyk M.L., Zmitrichenko Yu.G., Semenov A.L., Bespalov V.G., Semiglazova T.Yu. DOMESTIC ANTITUMOR COMPOUND 2-[3-(2-CHLOROETHYL)-3-NITROSOUREIDO]-1,3- PROPANEDIOL (CHLONISOL). ACUTE TOXICITY. Toxicological Review. 2020;(6):49-53. (In Russ.) https://doi.org/10.36946/0869-7922-2020-6-49-53
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