TOXICITY UNDER A SINGLE INTRAGASTRIC ADMINISTRATION OF THE ACTIVE CLATHRATE COMPLEX OF β-CYCLODEXTRIN WITH 3-(2-PHENYLETHYL)-2-THIOXO-1,3- THIAZOLIDIN-4-ONE
https://doi.org/10.36946/0869-7922-2020-6-59-62
Abstract
The clathrate complex of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one with β-cyclodextrin in the form of a nanopowder with an average particle size of 40.5 nm, with a wide range of pharmacological properties, was developed for the first time. It belongs to class VI of relatively harmless drugs according to Hodge and to class 5 in accordance with GOST 32644-2014.
About the Authors
K. T. Erimbetov
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after academician L.K. Ernst; Research Center «Park of Active Molecules»
Russian Federation
Russian Federation
Erimbetov Kenes Tagaevich
249013, Kaluga Region
R. A. Zemlyanoy
All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after academician L.K. Ernst
Russian Federation
Russian Federation
Zemlyanoy Ruslan Alexandrovich
249013, Kaluga Region
E. K. Bondarenko
Research Center «Park of Active Molecules»
Russian Federation
Russian Federation
Bondarenko Ekaterina Valer’evna
Obninsk, Kaluga region
A. Ya. Goncharova
Research Center «Park of Active Molecules»
Russian Federation
Russian Federation
Goncharova Anna Yakovlevna
Obninsk, Kaluga region
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Review
For citations:
Erimbetov K.T., Zemlyanoy R.A., Bondarenko E.K., Goncharova A.Ya. TOXICITY UNDER A SINGLE INTRAGASTRIC ADMINISTRATION OF THE ACTIVE CLATHRATE COMPLEX OF β-CYCLODEXTRIN WITH 3-(2-PHENYLETHYL)-2-THIOXO-1,3- THIAZOLIDIN-4-ONE. Toxicological Review. 2020;(6):59-62. (In Russ.) https://doi.org/10.36946/0869-7922-2020-6-59-62
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