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EFFECTIVENESS PROGNOSTICATION OF A COMBINED ANALGESIC FORMULATION DEPENDING ON QUANTITATIVE COMPOSITION OF ITS COMPONENTS
https://doi.org/10.36946/0869-7922-2016-5-44-48
Abstract
In experiments on rats, analgesic activity of fentanyl opioid receptor agonist and central 2-adrenomimetic dexmedetomidine as well as the character of their interaction at a combined administration were studied. Meaneffective anesthetic doses of the drugs in heat radiant tail flick test were 54.5 and 22.5 μg/kg correspondingly. Using izobolographic analysis, it was shown that for a combination with equal parts or with a greater part of fentanyl, the type of drug interaction can be characterized as potentiation. A model of prognostication of probability values of the analgesic effect development in relation to doses of combination components was elaborated and experimentally tested.
About the Authors
N. G. Vengerovich
State Research and Test Institute of Military Medicine, RF Ministry of Defense
Russian Federation
195043, Saint Petersburg
Russian Federation
195043, Saint Petersburg
M. A. Yudin
State Research and Test Institute of Military Medicine, RF Ministry of Defense
Russian Federation
195043, Saint Petersburg
Russian Federation
195043, Saint Petersburg
A. S. Nikiforov
State Research and Test Institute of Military Medicine, RF Ministry of Defense
Russian Federation
195043, Saint Petersburg
Russian Federation
195043, Saint Petersburg
G. S. Sagalov
S.M. Kirov Medical Military Academy, RF Ministry of Defense
Russian Federation
194044, Saint Petersburg
Russian Federation
194044, Saint Petersburg
M. S. Vakhviyainen
Innovative pharmaceutical company “Silver Pharm” Ltd
Russian Federation
195279, Saint Petersburg
Russian Federation
195279, Saint Petersburg
A. A. Kuzmin
State Research and Test Institute of Military Medicine, RF Ministry of Defense
Russian Federation
195043, Saint Petersburg
Russian Federation
195043, Saint Petersburg
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Review
For citations:
Vengerovich N.G., Yudin M.A., Nikiforov A.S., Sagalov G.S., Vakhviyainen M.S., Kuzmin A.A. EFFECTIVENESS PROGNOSTICATION OF A COMBINED ANALGESIC FORMULATION DEPENDING ON QUANTITATIVE COMPOSITION OF ITS COMPONENTS. Toxicological Review. 2016;(5):44-48. (In Russ.) https://doi.org/10.36946/0869-7922-2016-5-44-48
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