SOME PRINCIPLES AND MEANS OF INCREASING THE ORGANISM’S RESISTANCE TO ADVERSE EFFECTS OF METALCONTAINING NANOPARTICLES
https://doi.org/10.36946/0869-7922-2016-6-4-10
Abstract
Particularly high health risks associated with impacts of metal and metal oxide nanoparticles (Me-NPs), and their presence in the occupational environment, not only in nano-industry, but also in some long-existing technologies as well necessitates to maintain levels of hazardous exposures as low as possible and also to find ways to enhance the body’s resistance to them. The article briefly discusses the theoretical background of suсh a «bio-protection». The analysis of the most significant results of experiments with different Me-NPs, shows that against the background of properly selected combinations of certain biologically active agents used in harmless doses, it can be possible to significantly weaken integral and specific toxicity and even genotoxicity of metal-containing nanoparticles.
About the Authors
L. I. Privalova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
B. A. Katsnelson
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
V. B. Gurvich
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
I. A. Minigalieva
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
M. P. Sutunkova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
O. H. Makeyev
Central Research Laboratory, Ural State Medical University
Russian Federation
Russian Federation
I. E. Valamina
Central Research Laboratory, Ural State Medical University
Russian Federation
Russian Federation
V. Y. Shur
Ural Center for Shared Use «Modern Nanothechnologies»,Ural Federal University named after B.N. Eltsin, the first President of Russia
Russian Federation
Russian Federation
E. V. Grigoryeva
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
S. V. Klinova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor
Russian Federation
Russian Federation
E. V. Shishkina
Ural Center for Shared Use «Modern Nanothechnologies»,Ural Federal University named after B.N. Eltsin, the first President of Russia
Russian Federation
Russian Federation
References
1. Кацнельсон Б.А., Привалова Л.И., Сутункова М.П., Гурвич В.Б., Минигалиева И.А., Логинова Н.В. и др. Основные результаты токсикологических экспериментов «ин виво» с некоторыми металлическими и металло-оксидными наночастицами. Токсикологический Вестник. 2015; 3: 26-39.
2. Katsnelson B.A., Privalova L.I., Kuzmin S.V., Gurvich V.B., Sutunkova M.P., Kireyeva E.P. et al. An approach to tentative reference levels setting for nanoparticles in the workroom air based on comparing their toxicity with that of their micrometric counterparts: A case study of iron oxide Fe3O4. J. ISRN Nanotechnol. 2012; 2012. Available at: https://www.hindawi.com/ journals/isrn/2012/143613/
3. Katsnelson B.A., Privalova L.I., Sutunkova M.P., Minigalieva I.A., Gurvich V.B., Shur V.Y. et al. Is it possible to enhance the organism’s resistance to toxic effects of metallic nanoparticles? J. Toxicol. 2015; 337: 79-82.
4. Katsnelson B.A., Kuzmin S.V., Degtyareva T.D., Privalova L.I., Soloboyeva J.I. «Biological prophylaxis» – One of the ways to proceed from the analytical environmental epidemiology to the population health protection. Cent. Eur. J. Occup. Environ. Med. 2008; 14: 41–2.
5. Katsnelson B.A., Privalova L.I., Kuzmin S.V., Degtyareva T.D., Soloboyeva J.I. Biological Prophylaxis of Adverse Health Effects Caused by Environmental and Occupational Impacts – Theoretical Premises, Experimental and Field Testing, Practical Realization. Cent. Eur. J. Occup. Environ. Med. 2009; 14 (1-2): 35-57.
6. Katsnelson B.A., Privalova L.I., Gurvich V.B., Kuzmin S.V., Kireyeva E.P., Minigalieva I.A. et al. Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a SelfOverview). J. of Environ. Protect. 2014; 5: 1435–49.
7. Katsnelson B.A., Privalova L.I., Gurvich V.B., Makeyev O.H., Shur V.Y., Beikin Y.B. et al. Comparative in vivo assessment of some adverse bio-effects of equidimensional gold and silver nanoparticles and the attenuation of nanosilver’s effects with a complex of innocuous bioprotectors. Int. J. Mol. Sci. 2013; 14: 2449–83.
8. Privalova L.I., Katsnelson B.A., Loginova N.V., Gurvich V.B., Shur V.Y., Valamina I.E. et al. Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors. Int. J. Mol. Sci. 2014; 15: 12379–406
9. Minigalieva I.A., Katsnelson B.A., Privalova L.I., Sutunkova M.P., Gurvich V.B., Shur V.Ya. et al. Attenuation of combined nickel (II) oxide and manganese (II,III) oxide nanoparticles’ adverse effects with a complex of bioprotectors. Int. J. of Mol. Sci. 2015; 16 (9): 22555-83.
10. Katsnelson B.A., Privalova L.I., Sutunkova M.P., Minigaliyeva I.A., Panov V.G., Varaksin A.N. et al. Some patterns of metallic nanoparticles’ combined subchronic toxicity as exemplified by a combination of nickel and manganese oxide nanoparticles. J. Food Chem. Toxicol. 2015; 86: 351-64.
11. Morosova K.I., Katsnelson B.A., Rotenberg Yu.S., Belobragina G.V. A further experimental study of the antisilicotic effect of glutamate. Br. J. Ind. Med. 1984; 41(4): 518-25.
12. Fröhlich E. Cellular targets and mechanisms in the cytotoxic action of nonbiodegradable engineered nanoparticles. J. Curr. Drug Metab. 2013; 14: 976–88.
13. Karki P., Lee E., Aschner M. Manganese Neurotoxicity: a Focus on Glutamate Transporters. Ann. Occup. Environ. Med. 2013; 25 (1): 4.
14. White L.D., Cory-Slechta D.A., Gilbert M.E., Tiffany-Castiglioni E., Zawia N.H., Virgolini M. et al. New and evolving concepts of the neurotoxicology of lead. Toxicol. Appl. Pharmacol. 2007; 225: 1-27.
15. Desole M.S., Miele M., Esposito G., Migheli R., Fresu L., De Natale G. et al. Dopaminergic system activity and cellular defense mechanisms in the striatum and striatal synaptosomes of the rat subchronically exposed to manganese. Arch. Toxicol. 1994; 68: 566-70.
16. Привалова Л.И., Кацнельсон Б.А., Логинова Н.В., Гурвич В.Б., Шур В.Я., Макеев О.Г. и др. Пути повышения устойчивости организма к вредному действию наноматериалов на примере наносеребра и нанооксида меди. Гигиена и санитария. 2015; 94 (2): 31-5.
17. Кацнельсон Б.А., Минигалиева И.А., Привалова Л.И., Сутункова М.П., Гурвич В.Б., Шур В.Я. и др. Реакция глубоких дыхательных путей крысы на однократное интратрахеальное введения наночастиц оксидов никеля и марганца или их комбинации и ее ослабление биопротекторной премедикацией. Токсикологический вестник. 2014; 6: 8-14.
18. Кацнельсон Б.А., Макеев О.Г., Привалова Л.И., Сутункова М.П., Киреева Е.П., Минигалиева И.А. и др. О сравнительной генотоксичности наносеребра и нанозолота и возможности ее снижения комплексом биопротекторов. Токсикологический вестник. 2013; 2: 20-5.
Review
For citations:
Privalova L.I., Katsnelson B.A., Gurvich V.B., Minigalieva I.A., Sutunkova M.P., Makeyev O.H., Valamina I.E., Shur V.Y., Grigoryeva E.V., Klinova S.V., Shishkina E.V. SOME PRINCIPLES AND MEANS OF INCREASING THE ORGANISM’S RESISTANCE TO ADVERSE EFFECTS OF METALCONTAINING NANOPARTICLES. Toxicological Review. 2016;(6):4-10. (In Russ.) https://doi.org/10.36946/0869-7922-2016-6-4-10
Views:
481
Email this article 