MORPHOLOGICAL PECULIARITIES OF THE ACTION OF PEPTIDE DRUGS AT ACUTE POISONING WITH ETHYL ALCOHOL IN EXPERIMENT

Results of an investigation into liver morphological changes at acute poisoning with ethyl alcohol and their correction with molixan and semax combination are presented. Ethanol was administrated intragastrically as a 40% solution in a dose of 12 g/kg that corresponds to 1.5 LD₅₀. Semax was administrated intranasally in a dose of 3 mg/kg and molixan intraabdominally in a dose of 30 mg/kg. The preparations efficacy was evaluated using the following application schemes: prophylactic (single dose an hour prior to ethanol), therapeutic and prophylactic (an hour before and just after administration of ethanol), early therapeutic (just after administration of ethanol and then once daily during two next days) and delayed therapeutic (30 min after administration of ethanol and then once daily during two next days). The sampling of the material under investigation was performed 1 hour, 3 hours, 1 day and 3 days after modelling of the alcohol intoxication. It was found out that ethanol in a dose of 1.5 LD₅₀ induces changes in liver in the form of fatty, albuminous, hydropic degeneration, focal necrosis, stromal cell reactions. It was shown that the therapeutic and prophylactic application of the molixan and semax combination significantly reduces the intensity and prevalence of dystrophic and necrotic processes and stromal cell reactions in liver.

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