ASSOCIATION OF BCHE GENE POLYMORPHIC VARIANTS WITH BUTYRYLCHOLINESTERASE ACTIVITY IN RATS POISONED WITH MALATHION
Abstract
The association of Bche gene polymorphisms with butyrylcholinesterase activity was investigated on a model of rats poisoned with malathion at a dose of 1 LD50. The genotype distribution of six polymorphic variants of Bche gene was studied. An authentic association (p C (SNPID rs198598583), G>T (SNPID rs106118718), A>T (SNPID rs107226860) with butyrylcholinesterase activity in the liver tissue a day after poisoning was shown; the prevalence of those polymorphic variants is associated with linked type of inheritance. The highest linkage correlation of the enzyme activity in the liver was observed in variants A>T (rs107226860) and G>T (rs106118718). Enzyme activity in rats with a homozygous genotype was authentically higher ( by 30%) compared to the heterozygous genotype.
About the Authors
Aleksandr Vladimirovich Babkin
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Irina Sergeevna Berdinskih
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Natalya Sergeevna Osechkina
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Georgiy Valerevich Nazarov
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Mikhail Anatol’evich Judin
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Vladimir Nikolaevich Bykov
Scientific Research Test Institute of Military Medicine, S.M. Kirov Medical Military Academy
Russian Federation
Russian Federation
Andrey Mikhailovich Sarana
City Hospital № 40
Russian Federation
Russian Federation
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Review
For citations:
Babkin A.V., Berdinskih I.S., Osechkina N.S., Nazarov G.V., Judin M.A., Bykov V.N., Sarana A.M. ASSOCIATION OF BCHE GENE POLYMORPHIC VARIANTS WITH BUTYRYLCHOLINESTERASE ACTIVITY IN RATS POISONED WITH MALATHION. Toxicological Review. 2014;(5):16-20. (In Russ.)
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