ЭПИГЕНЕТИЧЕСКАЯ ТОКСИКОЛОГИЯ: ПЕРСПЕКТИВЫ РАЗВИТИЯ

Одной из сложных проблем современной экспериментальной токсикологии остаются молекулярные механизмы формирования нарушений здоровья людей в отдаленные сроки после острого либо хронического воздействия токсичных химических загрязнителей окружающей среды (экотоксикантов). Выявление и понимание того, какие эпигенетические изменения индуцируются окружающей средой, и как они могут приводить к неблагоприятным результатам, имеет жизненно важное значение для охраны здоровья населения. Поэтому мы рассматриваем современное понимание эпигенетических механизмов, участвующих в жизненном цикле млекопитающих, и оцениваем имеющиеся данные относительно экологически обусловленной эпигенетической токсичности, а соответственно, формирующейся эпигенетической (эпигеномной) регуляторной токсикологии.

эпигенетика, эпигеномика, эпигенетические механизмы, токсикоэпигенетика, эпигенетические изменения в раннем развитии, метилирование ДНК, бисфенол А, хлористый кадмий, клеточные культуры человека, хромосомы, хроматин, межпоколенческое наследование эпигенома после воздействия токсикантами

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