|Generate QR code
Open Access
Subscription Access
COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS
https://doi.org/10.36946/0869-7922-2016-2-19-24
Abstract
The cytotoxic action of skin antiseptics based on ethyl, propyl and isopropyl alcohols were investigated into the culture of human embryonic fibroblast cells using MTT-test and xCELLigence system for real-time analysis into the bull spermatozoa with registering toxicity index. The dependence of the cytotoxicity degree on the chemical composition of a preparation was established. The investigation of antiseptics skin-resorptive action mechanisms in weanling rats has shown that prepubertal females are more sensitive to the effect of alcohols compared to males. The use of skin antiseptics based on ethyl and isopropyl alcohols is recommended for hygienic treatment of children’s hands.
About the Authors
M. V. Bidevkina
Scientific Research Disinfectology Institute, Rospotrebnadzor
Russian Federation
Russian Federation
O. V. Baklanova
D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
T. Z. Rysina
Scientific Research Disinfectology Institute, Rospotrebnadzor
Russian Federation
Russian Federation
I. A. Suetina
D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
O. A. Lopatina
D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
T. N. Potapova
Scientific Research Disinfectology Institute, Rospotrebnadzor
Russian Federation
Russian Federation
M. V. Mezentseva
D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
A. V. Limantsev
Scientific Research Disinfectology Institute, Rospotrebnadzor
Russian Federation
Russian Federation
L. I. Russu
D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Russian Federation
Russian Federation
Zh. P. Alekseeva
Scientific Research Disinfectology Institute, Rospotrebnadzor
Russian Federation
Russian Federation
References
1. Тoxnetdatabase: http://chem.sis. nlm.nih.gov/chemidplus/rn/startswi th/64-17-5;/67-63-0;/71-23-8
2. Вредные вещества в окружающей среде. Кислородсодержащие органические соединения. Часть I /Под ред. В.А.Филова, Б.А.Ивина, Ю.И.Мусийчука.-С.-Пб.:НПО «Профессионал», 2007.-С. 15-18.
3. Kramer A. et al. Quantity of ethanol absorption after excessive hand disinfection using three commercially available hand rubs is minimal and below toxic levels for humans //BMC Infectious Diseases. – 2007. – Т. 7. – №. 1. – С. 117.
4. Below H. et al. Dermal and pulmonary absorption of propan-1-ol and propan-2- ol from hand rubs //American journal of infection control. – 2012. – Т. 40. – №. 3. – С. 250-257.
5. Экспресс-метод оценки общетоксического и кожно-раздражающего действия парфюмерно-косметической продукции invitro (на культуре подвижных клеток). МР № 29 ФЦ/394.ГоссанэпидслужбаРоссии.-2002 г.
6. MosmannT. Rapid colorimetric assay for cellular growth survival: application to proliferation and cytotoxicity assays. // J.Immunol.Methods.- 1983.- v.65(1-2).- p.55-63.
7. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под ред. Р.У. Хабриева. – 2-еизд. – М.: Изд. «Медицина», 2005, с.649-6
8. Atienza J.M., Zhu J., Wang X., Xu X., Abassi Y.A. Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. J.ofBiomol.Screen., 2005, 10, 795-805.
9. Методы лабораторных исследований и испытаний дезинфекционных средств для оценки их эффективности и безопасности, Руководство. Р 4.2643-М., 2011, с.523-525.
Review
For citations:
Bidevkina M.V., Baklanova O.V., Rysina T.Z., Suetina I.A., Lopatina O.A., Potapova T.N., Mezentseva M.V., Limantsev A.V., Russu L.I., Alekseeva Zh.P. COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS. Toxicological Review. 2016;(2):19-24. (In Russ.) https://doi.org/10.36946/0869-7922-2016-2-19-24
Views:
676
Email this article 