TOXICOLOGICAL AND BIOLOGICAL CHARACTERISTICS OF NEW N-SUBSTITUTED AMINOAMIDES
https://doi.org/10.36946/0869-7922-2018-4-46-49
Abstract
Functionally substituted amines containing amido and amino groups have a wide range of biological effects. Among them substances with various pharmacological activities were identified, and based on them a number of drugs were development. The paper presents toxicological characteristics of new substances and the relationship between the structure and pharmacological activity of aminoamides.
About the Authors
O. S. Kaldyrkaeva
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
E. V. Arzamastsev
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
E. Ya. Borisova
Russian Technological University / MIREA
Russian Federation
Russian Federation
O. A. Terekhova
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
E. Yu. Afanasieva
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
N. Yu. Borisova
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
E. L. Levitskaya
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
E. V. Kudryavtseva
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
T. V. Gaysinyuk
Russian Cardiology Research Center, RF Ministry of Healthcare
Russian Federation
Russian Federation
References
1. Dahlbom R., Karlen B., Lindquist A. et al. // Acta Pharm. Succia. 1967. V. 22. P. 1057
2. Пат. Италия №02396251 Производные альфа-аминоамидов, применяемые в качестве противовоспалительных агентов, 10.08.2010 Сальвати Патричия (IT) [Электронный ресурс] // URL: patentscope.wipo. int/search/en/detail.jsf?docId=ru29560141&redirecte dID=true
3. Пат. 1558926 Франция // С.А. 1970. V/ 72, 54893v.
4. Харкевич Д.А., Арендарук А.П., Сколдиков А.П. // Хим.-фарм. журн. 1968, №3, с. 7
5. Schoenberger H., Bindl L., Petter A.//Arch. Pharm. 1970. V. 303. P. 798
6. Г.А. Толстиков, Е.Я. Борисова, М.И. Черкашин, В.М. Комаров, Е.В. Арзамасцев, Успехи химии, 60, 852 (1991)
7. Deichman W.B., Le Blanc T.J. Determination of the approximate lethal dose with about six animals. J. Indust. Hyg. ToxicoL, 1943, 25, 9, 415-417.
8. Беленький М.Л. Элементы количественной оценки фармакологического эффекта. Л., «Медицина», 1963
9. Arzamastsev E.V. The safety of drugs at the stage of screening and preclinical toxicological studies. Lab. Zhyvotnye, 1991, Vol. 1, N 2, 60-64.
Review
For citations:
Kaldyrkaeva O.S., Arzamastsev E.V., Borisova E.Ya., Terekhova O.A., Afanasieva E.Yu., Borisova N.Yu., Levitskaya E.L., Kudryavtseva E.V., Gaysinyuk T.V. TOXICOLOGICAL AND BIOLOGICAL CHARACTERISTICS OF NEW N-SUBSTITUTED AMINOAMIDES. Toxicological Review. 2018;(4):46-49. (In Russ.) https://doi.org/10.36946/0869-7922-2018-4-46-49
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