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TOXICITY OF DIOCTYLTEREPHTHALATE

https://doi.org/10.36946/0869-7922-2018-6-47-49

Abstract

Dioctylterephthalate is a general-purpose plasticizer, has low toxicity, and does not irritate the mucous membranes of the eye and the skin; the maximum nonlethal dose (DL0) for dioctylterephthalate after intragastric administration is set at 10,000 mg/kg. Indicative safe exposure level for dioctylterephthalate in ambient air in urban and rural settlements is recommended at 0.5 mg/m3. Substance has low acute toxicity; the maximum inactive dose is set at 4 mg/kg. The substance has low solubility in water (0.4 μg/l), does not affect the dynamics of biochemical oxygen consumption. Threshold concentration in water on organoleptic characteristic is set at 0.25 mg/l as for low hazard substances.

About the Authors

R. A. Mamonov
Center for Strategic Planning and Management of Biomedical Health Risks, RF Ministry of Health.
Russian Federation
119121, Moscow.


L. A. Fedotova
Center for Strategic Planning and Management of Biomedical Health Risks, RF Ministry of Health; Russian Medical Academy of Continuous Professional Education, RF Ministry of Health.
Russian Federation

119121, Moscow.

125993, Moscow.



I. A. Pechnikova
Center for Strategic Planning and Management of Biomedical Health Risks, RF Ministry of Health.
Russian Federation
119121, Moscow.


T. D. Potapchenko
Center for Strategic Planning and Management of Biomedical Health Risks, RF Ministry of Health.
Russian Federation
119121, Moscow.


References

1. Temporary methodical instructions on justification of maximum permissible concentrations (MPC) of pollutants in atmospheric air of inhabited places, VMU No. 4681-88. (n Russian)

2. Justification of hygienic standards of chemicals in water of water objects of economicdrinking and cultural-household water use: Methodical instructions. MU 2.1.5.720-8. - M.: Federal center of Gossanepidnadzor of the Ministry of Health of the Russian Federation, 1999. (n Russian)


Review

For citations:


Mamonov R.A., Fedotova L.A., Pechnikova I.A., Potapchenko T.D. TOXICITY OF DIOCTYLTEREPHTHALATE. Toxicological Review. 2018;(6):47-49. (In Russ.) https://doi.org/10.36946/0869-7922-2018-6-47-49

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ISSN 0869-7922 (Print)