ASSESSMENT OF TOXICITY AND HAZARD OF TECHNICAL PRODUCT OF TRIAZINONE’S DERIVATIVE
https://doi.org/10.36946/0869-7922-2019-1-39-42
Abstract
Experimental assessment of toxicity and hazard of technical product of triazinone’s derivative at its peroral administration into warm-blooded animals’ bodies (male rats) has been conducted to determine the character of the substance biological action. Its acute peroral toxicity was at the level of LD50 -1693 ± 470 mg/kg of body weight, hazard class – 4 according to Hygienic Classification of Pesticides (Sanitary Rules & Standards 1.2.2584-10). Effective dose was 62.5 mg/kg b.w., non-effective dose (NOEL) was 12.5 mg/kg b.w. ADI was 0.1 mg/kg b.w.
About the Authors
V. N. Rakitskii
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Russian Federation
Russian Federation
Rakitskii Valery Nikolaevich
141014, Mytishchi, Moscow Region,
T. M. Еpishina
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Russian Federation
Russian Federation
Epishina Tatiana Mihailovna
141014, Mytishchi, Moscow Region,
E. G. Chkhvirkiya
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Russian Federation
Russian Federation
Chkhvirkiya Elena Grigor'evna
141014, Mytishchi, Moscow Region,
T A. Sinitskaya
F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Russian Federation
Russian Federation
Sinitskaya Tat'yana Alekseevna
141014, Mytishchi, Moscow Region,
Е. A. Mukhina
.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor
Russian Federation
Russian Federation
Mukhina Ekaterina Aleksandrovna
141014, Mytishchi, Moscow Region,
References
1. Rakitskii V.N. Hygienic principles and criteria of pesticide danger (risk) assessment. In:Collection of Studies: Hygienic Aspects of Environment and Public Health Protection. Sbornik nauchnykh trudov: Gigienicheskie aspekty okhrany okruzhayushchry sredy I zdoron’ya naseleniya. Moscow;1999.(in Russian)
2. Sinitskaya T.A., Malinovskaya H.H.Toxicological-hygienic justification of the acceptable daily intake of acetamiprid. М. Gigiena and sanitariy. 2016; 95(11):1055-1058.
3. Methodical instruction on hygienic assessment of new pesticides. Kiev. 1988; 210 p.
4. Kagan Y.S. General pesticide toxicology. – Kiev. Zdorovie. 1981; 176 р.
5. Rylova M.L. Method of exploring chronic action of adverse environment factors in theexperiment. L., Medicine.1964; 227 р.
6. Pavlenko S.M. Application of summation-threshold index in toxicological experiment on white rats. Methodic of sanitary-toxicological experiment: scientific works collections of MNIIG named after F.F.Erisman. M. 1975; 5-
7. Methodical recommendation on using reaction of animals’ behaviour in toxicological researches for hygienic standartization. Kiev. 1980; 47 p.
8. Anokhin P.K. Surveys on functional systems physiology.M. Medicine. 1975; 448р.
9. Clinical biochemistry: Manual for laboratory doctors. Kalb V.G., Kamyshnikov V.S. Minsk, Byelorussia. 1976; 311p.
Review
For citations:
Rakitskii V.N., Еpishina T.M., Chkhvirkiya E.G., Sinitskaya T.A., Mukhina Е.A. ASSESSMENT OF TOXICITY AND HAZARD OF TECHNICAL PRODUCT OF TRIAZINONE’S DERIVATIVE. Toxicological Review. 2019;(1):39-42. (In Russ.) https://doi.org/10.36946/0869-7922-2019-1-39-42
Views:
929
Email this article 