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News on toxicity and hazard of chemical and biological substances
https://doi.org/10.36946/0869-7922-2016-2-52-55
Abstract
Aluminosilicate clay nanotubes (ANT, halloysite clay) are considered as a new class of carriers for biologically active substances. The study was conducted in accordance with regulatory guidance documents in force for the purpose of experimental evaluation of acute toxicity and hazard of ANT intragastrically administrated and applied to the skin in mice and rats. It is shown that the tubular enriched kaolin (aluminosilicate clay nanotubes) (production of °SC «NT&I», Russia) in accordance with GOST 12.1.007-76 may be referred to hazard class 4 (low hazard substance). Based on the results of the study, it could be said that a promising nano-sized material (ANT) was produced that can be used as a drug carrier for medications.
About the Authors
N. M. Mitrokhin
Joint-stock Company «National Research Center for Biologically Active Compounds»
Russian Federation
Russian Federation
M. I. Golubeva
Joint-stock Company «National Research Center for Biologically Active Compounds»
Russian Federation
Russian Federation
I. N. Razumnaya
Joint-stock Company «National Research Center for Biologically Active Compounds»
Russian Federation
Russian Federation
S. A. Fastov
Closed Joint-Stock Company «Nanotechnologies & Innovations» (JSC N&T)
Russian Federation
Russian Federation
I. S. Fastov
Closed Joint-Stock Company «Nanotechnologies & Innovations» (JSC N&T)
Russian Federation
Russian Federation
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Review
For citations:
Mitrokhin N.M., Golubeva M.I., Razumnaya I.N., Fastov S.A., Fastov I.S. News on toxicity and hazard of chemical and biological substances. Toxicological Review. 2016;(2):52-55. (In Russ.) https://doi.org/10.36946/0869-7922-2016-2-52-55
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