NEUROPEPTIDES EFFECTS ON RAT ESTROUS CYCLE DISORDERS CAUSED BY MORPHINE
https://doi.org/10.36946/0869-7922-2019-5-33-38
Abstract
The aim of the study was to evaluate the influence of the Delta sleep-inducing peptide (DSIP) or the analogue of the adrenocorticotropin4-10 fragment (FACTH) on changes in the estrous cycle of rats caused by long-term administration of morphine. It has been found that the intranasal administration of DSIP or FACTH for 14 days did not lead to significant changes in the estrous cycle in mature female inbred rats. The introduction of morphine at a dose of 60 mg/kg for 60 days was accompanied by a statistically significant change in the duration and structure of the estrous cycle in experimental animals: a decrease in the duration of the estrus period to 1,50 ± 0,17 days and an increase in interintegration to 8,30 ± 0,80 days, as well as the total duration of the estrous cycle up to 9,60 ± 0,65 days. In turn, the use of DSIP and FACTH for 14 days after the administration of morphine at a dose of 60 mg/kg for 60 days led to the normalization of the structure and duration of the estrous cycle in mature female inbred rats.
About the Authors
N. A. Belyakova
Institute of Toxicology of the Federal Medical-Biological Agency
Russian Federation
Russian Federation
Belyakova Nataliya Alexandrovna
192019, Saint Petersburg
E. Yu. Bonitenko
N.F. Izmerov Research Institute of Occupational Health
Russian Federation
Russian Federation
Bonitenko Evgeniy Yur’evich
105275, MoscowA. V. Nosov
Institute of Toxicology, Federal Medical-Biological Agency
Russian Federation
Russian Federation
Nosov Andrey Victorovich
192019, Saint Petersburg
References
1. Schrijvers D., van Fraeyenhove F. (2010). Emergencies in palliative care. Cancer J. 2010; Vol.16, No. P. 514-520.
2. Pollova K. M., ed., Introduction to reproductive endocrinology. M: Meridian, 2000 (in Russian).
3. Kulakov V. I., Leonova V. B., Kuzmicheva L. N., ed. Treatment of female and male infertility. M.: MIA, 2005 (in Russian).
4. Weller Y., Theis M., Zawta B. Useful facts about reproductive medicine fertility testing. The question and answers. Dresden: Roshe Diagnostics GmbH, 20
5. Belyakova N. A., Bonitenko E. Yu., Nosov A.V., Generalova K. R., Lisitsky D. S. Influence of neuropeptides on reproductive function in female noninbred rats. Biomedical journal Medline. ru. 2019, Vol. 20, No. 1, Pp. 1-16 (in Russian).
6. Kotelnikov A.V., Kotelnikova S. V. Characteristics of the estrous cycle in white rats at different stages of ontogenesis with the introduction of vitamin E. Bulletin of the Astrakhan State Technical University. 2005, T2, No. Pp. 25 - 27 (in Russian).
7. Savchenko O. N., Аrutyunyan N. A., Stepanov M. G. Experimental infertility. SPb.: Science, 1992 (in Russian).
8. Zarubina E. G., Lysova A. N. Role of kisspeptin in the normalization of the estrous cycle in adult mature female rats. The electronic scientific journal ISSN2070-74The category of «Medical science», 2015 (in Russian).
Review
For citations:
Belyakova N.A., Bonitenko E.Yu., Nosov A.V. NEUROPEPTIDES EFFECTS ON RAT ESTROUS CYCLE DISORDERS CAUSED BY MORPHINE. Toxicological Review. 2019;(5):33-38. (In Russ.) https://doi.org/10.36946/0869-7922-2019-5-33-38
Views:
788
Email this article 