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SPECIFICITIES OF DETECTION OF FENTANYL DERIVATES IN URINE USING METHODS OF LIQUID AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY
https://doi.org/10.36946/0869-7922-2016-3-41-46
Abstract
SPECIFICITIES OF DETECTION OF FENTANYL DERIVATES IN URINE USING METHODS OF LIQUID AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY Recently in the Leningrad region, cases of poisoning associated with taking fentanyl derivatives (Carfentanyl, 3-Methylfentanyl) became more frequent. Analytical information about taking those compounds by persons brought to central district hospitals with symptoms of drug intoxication gives rise to certain methodological difficulties that are caused by low concentrations of toxic substances in blood and urine and limited metabolism data. Using methods of liquid and gas chromatography-mass spectrometry (GC-MS and LC-MS / MS), urinary metabolites of fentanyl derivatives were identified. Methods for samples preparation based on liquid-liquid or solid-phase extraction are suggested. It is recommended to use LC-MS/MS methods to detect metabolites and unmodified forms of fentanyl derivatives in blood and urine of patients under examination. Results of the practical application of developed methods are reported.
About the Authors
O. L. Zaikina
ГКУЗ Ленинградский областной наркологический диспансер, химико-токсикологическая лаборатория
Russian Federation
Russian Federation
V. V. Shilov
ФГБОУ ВО «Северо-западный государственный медицинский университет им. И.И.Мечникова» Минздрава России
Russian Federation
Russian Federation
A. N. Lodyagin
ГБУ «Санкт-Петербургский научно-исследовательский институт скорой помощи им. И.И.Джанелидзе»
Russian Federation
Russian Federation
A. M. Grigor’ev
ГБУЗ МО «Бюро СМЭ», судебно-химическое отделение
Russian Federation
Russian Federation
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Review
For citations:
Zaikina O.L., Shilov V.V., Lodyagin A.N., Grigor’ev A.M. SPECIFICITIES OF DETECTION OF FENTANYL DERIVATES IN URINE USING METHODS OF LIQUID AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY. Toxicological Review. 2016;(3):41-46. (In Russ.) https://doi.org/10.36946/0869-7922-2016-3-41-46
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