Indicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experiment

The article presents experimental data on the state of the antioxidant system in red blood cells of white outbred rats 1 and 3 months after acute mercury nitrate poisoning with a semilethal dose. It has been established that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, and an increase in the concentration of lipid peroxidation products).

It has been shown that the mercury content in the blood of experimental animals remains elevated during the entire study period.

The results obtained indicate the importance of impaired functioning of the antioxidant system in the implementation of long-term consequences of acute mercury poisoning. The reasons for the occurrence of these biochemical shifts and their role in the development of the long-term cytotoxic effects of mercury nitrate are discussed.

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50. Malov A.M., Sibiryakov V.K., Semenov E.V. The effect of mercury on the content of free SH-groups in the blood plasma of rats and humans. Toxicological Bulletin. 2012; 3 (114): 20-24 (in Russian).

51. Sears M.E. Chelation: Harnessing and enhancing heavy metal detoxification– a review. The Scientific World Journal. 2013; 13.

52. Kashuro V.A., Karpishchenko A.I., Kutsenko S.A., Glushkov S.I. The possibility of using the definition of indicators of the glutathione system in the laboratory diagnosis of complications of course treatment with cyclophosphamide. Clinical laboratory diagnostics. 2002; (10): 43 (in Russian).

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55. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011; 15–16: 555–563.

56. Sears M.E. Chelation: Harnessing and enhancing heavy metal detoxification– a review. The Scientific World Journal. 2013; 13.

57. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.

58. Ynalvez R., Gutierrez J., Gonzalez-Cantu H. Mini-review: toxicity of mercury as a consequence of enzyme alteration. Biometals. 2016; 5: 781–788.

59. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.

60. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011; 15–16: 555–563.

61. Ishii T., Mann G.E. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance. Redox Bio l. 2014; 2:786–794.

62. Keum Y.-S., Choi B.Y. Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway. Molecules .2014; 7: 10074-10089.