EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING
https://doi.org/10.36946/0869-7922-2020-3-14-18
Abstract
A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.
About the Author
A. M. Fomin
Moscow Regional Research and Clinical Institute (MONIKI), Ministry of Health of the Moscow Region
Russian Federation
Russian Federation
Fomin Aleksandr Mikhaylovich
129110, Moscow
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Review
For citations:
Fomin A.M. EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING. Toxicological Review. 2020;(3):14-18. (In Russ.) https://doi.org/10.36946/0869-7922-2020-3-14-18
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