ABOUT THE POSSIBILITY OF TOXIC EFFECTS DEVELOPING IN CONTACT WITH N-NITROSOALKYLUREA DERIVATIVE - LYSOMUSTINE
https://doi.org/10.36946/0869-7922-2020-3-4-34-38
Abstract
The paper presents the results of a study on the possibility of toxic effects developing in contact with the antitumor drug – lysomustine - to assess the health risk in the manufacture of the finished dosage form and its use. The work was performed on 40 outbred rats, 40 guinea pigs and 114 outbred mice. The experimental study has showed that lysomustine does not irritate intact skin, is not a potential allergen, has no skin-resorptive effect, does not cause reproductive disorders. The drug reveales mutagenic properties inherent in many cytostatics, representatives of the class of N-nitrosoalkylureas. The research results allow to conclude that the presence of the drug in the air of industrial premises and on the skin of workers in its manufacture and use of the finished dosage form is unacceptable.
About the Authors
K. I. Stosman
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Stosman Kira Iosiphovna
192019, Saint Petersburg
L. V. Lukovnikova
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Lukovnikova Lubov Vladimirovna
192019, Saint Petersburg
G. I. Sidorin
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Sidorin Gennadij Ivanovich
192019, Saint Petersburg
L. I. Dyakova
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Dyakova Lyudmila Ivanovna
192019, Saint Petersburg
E. P. Zatsepin
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Zatsepin Eduard Pavlovich
192019, Saint Petersburg
G. V. Shestova
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Shestova Galina Vladimirovna
Russian Federation
Shestova Galina Vladimirovna
192019, Saint Petersburg
B. S. Litvintsev
Institute of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Litvintsev Bogdan Sergeevich
192019, Saint Petersburg
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Review
For citations:
Stosman K.I., Lukovnikova L.V., Sidorin G.I., Dyakova L.I., Zatsepin E.P., Shestova G.V., Litvintsev B.S. ABOUT THE POSSIBILITY OF TOXIC EFFECTS DEVELOPING IN CONTACT WITH N-NITROSOALKYLUREA DERIVATIVE - LYSOMUSTINE. Toxicological Review. 2020;(4):34-38. (In Russ.) https://doi.org/10.36946/0869-7922-2020-3-4-34-38
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