TOXICITY AND HAZARD OF ZOLMITRIPTAN (EXPERIMENTAL STUDY)

Abstract

Zolmitriptan is a widely used antimigraine drug, belongs to the group of second-generation tryptans, has a pronounced central mechanism of action and high selectivity to serotonin receptors of 5HT_1D- and 5HT_1B-types. Zolmitriptan belongs to hazard class 3 according to GOST 12.1.007-76: DL₅₀ are 660 (495 - 881) mg/kg for male mice and 1045 (749 - 1292) mg/kg for female mice when administered into the stomach. When injected into the abdominal cavity, DL₅₀ is 172 (131 - 225) mg/kg for male mice. The drug has a weak irritating effect on the mucous membranes of the eyes, does not irritate the skin, there are no signs of skin-resorptive action, and has a low ability to accumulate. The threshold of acute inhalation action is set at 0,9 mg/m3 for the effect on the functional state of the nervous system and liver. For the zolmitriptan aerosol, it is recommended to approve the tentative safe exposure level in the air of the working area at 0,01 mg/m³ and the tentative safe exposure level in the atmospheric air of urban and rural settlements at 0,0001 mg/m³.