RELATIONSHIP BETWEEN METABOLIC AND IMMUNOLOGICAL INDICATORS AFTER CORRECTION BY ALLOGENIC HEPATOCYTES IN ACUTE TOXIC, ISCHEMIC AND ALCOHOL LIVER INJURY
https://doi.org/10.36946/0869-7922-2021-1-27-37
Abstract
Immune disorders arising from liver damage of various origins and the mechanisms of their development are still poorly understood. The functions of the immune system are carried out against the background of metabolic processes and their shifts caused by the action of various agents on the body, as well as liver cells - hepatocytes. Typical metabolic changes that occur when the liver is affected by various toxic factors are combined with certain features of metabolic disorders in certain organs and tissues, due to the specifics of their structural and functional organization, the nature of the inducing agent and the primary link of its effect on cells and the body as a whole. The relationship of numerous metabolic changes, violations of the functional activity of hepatocytes arising in such a pathology with the dysfunction of the immune system has not yet been sufficiently studied, as well as the most effective methods of correction have not been established. Currently, the issues of pathogenesis, diagnosis and treatment of acute liver diseases remain among the most relevant in medicine, both due to the complexity of diagnosis and the choice of optimal treatment methods, and the tendency towards an increase in the number of patients with these diseases. The emergence and development of cellular technologies have created serious scientific prerequisites in this area.
About the Authors
Е. S. Litvinova
Kursk State Medical University
Russian Federation
Russian Federation
Litvinova Ekaterina Sergeevna
305041, Kursk Region, Kursk
A. I. Konoplya
Kursk State Medical University
Russian Federation
Russian Federation
Konoplya Aleksandr Ivanovich
305041, Kursk Region, Kursk
I. M. Kholimenko
Kursk City Clinical Hospital for Emergency Medicine
Russian Federation
Russian Federation
Kholimenko Ivan Mikhajlovich
305047, Kursk Region, Kursk
A. G. Kotsar’
Kursk City Clinical Hospital for Emergency Medicine
Russian Federation
Russian Federation
Kotsar’ Aleksandr Gennad’evich
305047, Kursk Region, Kursk
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Review
For citations:
Litvinova Е.S., Konoplya A.I., Kholimenko I.M., Kotsar’ A.G. RELATIONSHIP BETWEEN METABOLIC AND IMMUNOLOGICAL INDICATORS AFTER CORRECTION BY ALLOGENIC HEPATOCYTES IN ACUTE TOXIC, ISCHEMIC AND ALCOHOL LIVER INJURY. Toxicological Review. 2021;1(1):27-37. (In Russ.) https://doi.org/10.36946/0869-7922-2021-1-27-37
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