PRECLINICAL STUDY OF GENERAL TOXICITY OF ADELACTTМ IN RODENT MODELS
Abstract
Toxicity of AdeLact™, a novel medicinal product on the basis of recombinant pseudo-adenoviral particles expressing human lactoferrin gene, was studied. Acute toxicity was evaluated in mice and rats, and sub-chronic toxicity was evaluated in rats and rabbits. According to its acute toxicity, AdeLact™ was classified as a low hazardous preparation and according to its sub-chronic toxicity, as a moderate hazardous preparation. In toxic doses, AdeLact™demonstrated moderate hepatic and renotropic toxicity. Inflammatory processes might develop in lungs after administration of AdeLact™. Intravenous infusion of AdeLact™ produces a mild and fully recoverable local effect.
About the Authors
Raisa Ivanovna Yakubovskaya
Federal State Budgetary Institution «P.A. Gerzen Moscow Research Institute of Oncology», RF Ministry of Health
Russian Federation
Russian Federation
Andrey Alexandrovich Pankratov
Federal State Budgetary Institution «P.A. Gerzen Moscow Research Institute of Oncology», RF Ministry of Health
Russian Federation
Russian Federation
Tatyana Nikolaevna Andreeva
Federal State Budgetary Institution «P.A. Gerzen Moscow Research Institute of Oncology», RF Ministry of Health
Russian Federation
Russian Federation
Julia Borisovna Venediktova
Federal State Budgetary Institution «P.A. Gerzen Moscow Research Institute of Oncology», RF Ministry of Health
Russian Federation
Russian Federation
Olga Alexeevna Bezborodova
Federal State Budgetary Institution «P.A. Gerzen Moscow Research Institute of Oncology», RF Ministry of Health
Russian Federation
Russian Federation
Irina Leonidovna Tutykhina
Federal State Budgetary Institution «N.F. Gamaleya Research Institute of Epidemiology and Microbiology», RF Ministry of
Helath
Russian Federation
Russian Federation
Evgeniy Valer’evich Evgrafov
Federal State Budgetary Institution «N.F. Gamaleya Research Institute of Epidemiology and Microbiology», RF Ministry of
Helath
Russian Federation
Russian Federation
Denis Yur’evich Logunov
Federal State Budgetary Institution «N.F. Gamaleya Research Institute of Epidemiology and Microbiology», RF Ministry of
Helath
Russian Federation
Russian Federation
Maxim Mihailovich Shmarov
Federal State Budgetary Institution «N.F. Gamaleya Research Institute of Epidemiology and Microbiology», RF Ministry of
Helath
Russian Federation
Russian Federation
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Review
For citations:
Yakubovskaya R.I., Pankratov A.A., Andreeva T.N., Venediktova J.B., Bezborodova O.A., Tutykhina I.L., Evgrafov E.V., Logunov D.Yu., Shmarov M.M. PRECLINICAL STUDY OF GENERAL TOXICITY OF ADELACTTМ IN RODENT MODELS. Toxicological Review. 2015;(2):18-25. (In Russ.)
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