CORRECTION OF THE KIDNEYS STRUCTURE DISTURBANCES IN RATS WITH SUBLIMATE NEPHROPATHY USING A COMBINATION OF TAURIN WITH ZINC DIASPARTATE
Abstract
A combination of taurine (20g/mole, 2.5 g) with zinc diaspartate (1 g/mole, 0.35g) named “taucine”, administrated in the rat stomach at doses of 250 mg/kg and 500 mg/kg over 14 days has a dose-dependent nephro-protective action in rats with sublimate nephropathy ( intraabdominally 0.1 mg/kg over 14 days) . It manifests in an increased volume of the primary urine in cortical nephrons glomerales because of a weakened compression of their capsule by hydropic fluid, in reduction of the inner diameter of cortical nephrons proximal convoluted tubules as consequence of a less pronounced «inner tubular» hydronephrosis and increased height of lining epithelial cells. A detailed analysis of the latter shows that they are less damaged by sublimate: the percentage of undamaged cells increases because of decrease with destruction of apical sections and increase of cells height by ½ as well.
About the Authors
Olga Nikolaevna Basalai
УО «Гродненский государственный медицинский университет» МЗ РБ
Belarus
Belarus
Elena Cheslavovna Mikhalchuk
УО «Гродненский государственный медицинский университет» МЗ РБ
Belarus
Belarus
Mikhail Ivanovich Bushma
УО «Гродненский государственный медицинский университет» МЗ РБ
Belarus
Belarus
Sergey Mikhaylovich Zimatkin
УО «Гродненский государственный медицинский университет» МЗ РБ
Belarus
Belarus
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Review
For citations:
Basalai O.N., Mikhalchuk E.Ch., Bushma M.I., Zimatkin S.M. CORRECTION OF THE KIDNEYS STRUCTURE DISTURBANCES IN RATS WITH SUBLIMATE NEPHROPATHY USING A COMBINATION OF TAURIN WITH ZINC DIASPARTATE. Toxicological Review. 2015;(2):31-34. (In Russ.)
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