INFLUENCE OF POTASSIUM BICHROMATE ON BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS ORGANISM
Abstract
The impact of potassium dichromate on immunological and biochemical parameters in Wistar rats was investigated in a model experiment . In the first place it was found out that a lasting uptake of chromium by the Wistar rat organism produces a depressive influence on the spleen quantitative and functional characteristics in laboratory animals; secondly, it was established that revealed shifts in the immune system parameters are caused by an increased intensity of free radical oxidation (FRO) in rats ( blood serum, spleen, liver) and lipid peroxidation (LPO), shown in an increasing concentration of conjugated dienes (CD) and malon dialdehyde (MDA) in spleen and liver against the background of the catalase decreased activity and superoxide dismutase (SOD) -erythrocytes in rats; and third, revealed mechanisms accounting for changes in immunological indicators present an experimental validation to elaborate approaches to preventing adverse effects of that xenobiotic .
About the Authors
Irina Valer’evna Mikhaylova
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Russian Federation
Russian Federation
Aleksandr Ivanovich Smolyagin
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Russian Federation
Russian Federation
Sergey Ivanovich Kraskov
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Russian Federation
Russian Federation
Evgenija Vjacheslavovna Ermolina
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Russian Federation
Russian Federation
Viktor Mihajlovich Boev
SBEI «Orenburg State Medical University», Ministry of Health of Russia
Russian Federation
Russian Federation
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Review
For citations:
Mikhaylova I.V., Smolyagin A.I., Kraskov S.I., Ermolina E.V., Boev V.M. INFLUENCE OF POTASSIUM BICHROMATE ON BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS ORGANISM. Toxicological Review. 2015;(3):21-25. (In Russ.)
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