EFFETIVE AND SAFE MODIFIED CARBON SORBENTS BASED ON NANOGLOBOLAR CARBON FOR MEDICAL AND VETERINARY PURPOSES

At the Institute of Hydrocarbon Processing, Siberian Branch of the Russian Academy of Sciences, technological approaches were developed to the targeted synthesis of porous carbon-carbon materials of a new class based on nanoglobular dispersed carbon (particle diameter 40-60 nm). Carbon materials for medical purposes are carbon hemosorbent in sterile saline VNIITU-1, carbon enterosorbent VNIITU-2, carbon enterosorbent Zookarb and modified materials derived from them that are safe and effective drugs for solving problems in medicine and veterinary. The article reports investigation results of effects posed by hemosorbent VNIITU-1 on blood plasma biochemical parameters in patients with peritonitis (substances with low and medium molecular weight, creatinine and ammonia). The results of the study on using enterosorbent Zookarb at chronic intoxication of animals with heavy metals – zinc and iron compounds are presented. The efficiency of samples of carbon hemosorbent and enterosorbent modified with polyarginine against pro-inflammatory cytokines (interleukin 6, interleukin 8) was assessed.

Carbon sorbents, nanoglobular carbon, Institute of Hydrocarbons Processing, Siberian Branch of the Russian Academy of Sciences, safety requirements for drugs, carbon hemosorbent in sterile saline solution VNIITU-, carbon enterosorbent Zookarb, composite veterinary drug «betulin in the carbon microsphere», carbon sorbent with polyarginine

1. Суровикин В.Ф., Пьянова Л.Г., Лузянина Л.С. Новые гемо- и энтеросорбенты на основе нанодисперсных углерод-углеродных материалов. Рос хим. ж. (Ж. Рос. хим. об-ва им. Д.М. Менделеева). 2007; Т.LI. №5: 159-165.

2. Малахова М.Я. Метод регистрации эндогенной интоксикации: пособие для врачей. СПб.: ИАПО; 1995.

3. Гланц С. Медико-биологическая статистика: Пер. с англ. М.: Практика;1998.

4. Пьянова Л.Г. Углеродные сорбенты в медицине и протеомике. Химия в интересах устойчивого развития. 2011; 19 (1): 113.

5. Лихолобов В.А., Пьянова Л.Г., Бакланова О.Н., Седанова А.В. Модифицированные материалы на основе нанодисперсного углерода. Химия твердого топлива. 2014; 6: 57-66.

6. P’yanova L.G., Gerunova L.K., Likholobov V.A., Sedanova A.V., Okolelov V.I., Lavrenov A.V. Development of carbon sorbents based on nanodispersed carbon using biotechnology. Procedia Engineering, 2016; 152: 655–663.

7. Пьянова Л.Г. Разработка и фармакотоксикологическая оценка модифицированных биологически активными веществами сорбентов ветеринарного назначения на основе нанодисперсного углерода: Автореф. Дис. канд. – Казань; 2016.