A STUDY OF ATROPINE INFLUENCE ON ACHE AND BCHE GENES EXPRESSION IN RATS EXPOSED TO MALATHION POISONING
Abstract
Levels of expression of Ache and Bche genes in tissue samples were investigated in rats exposed to malathion in dose of 1 LD50 and following atropine treatment. Malathion poisoning causes statistically significant decrease in levels of expression of Ache and Bche genes in brain and liver. The decrease of expression of these genes was greater than 50% and remained at this level during 14 days. It was shown that atropine treatment prevents decrease in Ache gene expression in brain. These findings suggest the possibility of gene expression level assessment in brain during the screening of promising treatments for OP poisoning.
About the Authors
Aleksandr Vladimirovich Babkin
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Russian Federation
Russian Federation
Irina Sergeevna Berdinskih
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Russian Federation
Russian Federation
Natalya Sergeevna Osechkina
Federal State Scientific Institution «Institute of Toxicology» Federal Medico-Biological Agency of Russia
Russian Federation
Russian Federation
Georgiy Valerevich Nazarov
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Russian Federation
Russian Federation
Mikhail Anatol’evich Yudin
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Russian Federation
Russian Federation
Vladimir Nikolaevich Bykov
Scientific Research Test Institute of Military Medicine of Medical Military Academy named after S.M. Kirov (The Russian Federation Department of Defense)
Russian Federation
Russian Federation
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Review
For citations:
Babkin A.V., Berdinskih I.S., Osechkina N.S., Nazarov G.V., Yudin M.A., Bykov V.N. A STUDY OF ATROPINE INFLUENCE ON ACHE AND BCHE GENES EXPRESSION IN RATS EXPOSED TO MALATHION POISONING. Toxicological Review. 2015;(6):22-26. (In Russ.)
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