TOXICOLOGICAL EVALUATION OF BIOACTIVE COMPOSITIONS BASED ON HYALURONIC ACID MODIFIED WITH VITAMINS AND AMINO ACIDS
Abstract
Experimental studies of the biological action of the preparation (Hyalrepair-02) based on hyaluronic acid or its salt modified with ascorbic acid and amino acids were carried out in white rats. It was established that the drug did not produce any adverse effects on the animals organism: haemotological, biochemical and other indicators characterizing the state of systems and organs of animals exposed to test compounds had no statistically significant differences from similar control indicators . Based on the first stage of the studies, it could be said that this non-toxic compound may be used in cosmetics to treat minor facial defects to be aesthetically corrected (wrinkles, scars, etc.), in mesotherapy, biorevitalisation, bioreparation, contouring plastics and reconstructive surgery to replace soft tissues in traumatology for joint fluid replacement.
About the Authors
Anna Valeriyevna Karamysheva
Federal State Budgetary Institution «All-Russian Scientific-Research and Testing Institute of Medical Engineering», Federal Service for Surveillance in Healthcare
Russian Federation
Russian Federation
Grigory Valentinovich Son
Federal State Budgetary Institution «All-Russian Scientific-Research and Testing Institute of Medical Engineering», Federal Service for Surveillance in Healthcare
Russian Federation
Russian Federation
Nina Mikhaelovna Perova
Federal State Budgetary Institution «All-Russian Scientific-Research and Testing Institute of Medical Engineering», Federal Service for Surveillance in Healthcare
Russian Federation
Russian Federation
Maxim Valerievich Mnikhovich
Federal State Budgetary Institution «All-Russian Scientific-Research and Testing Institute of Medical Engineering», Federal Service for Surveillance in Healthcare
Russian Federation
Russian Federation
Sergey Alekseevich Uspenskii
АНО «Международный научно-исследовательский центр инновационных технологий МАРТИНЕКС»
Russian Federation
Russian Federation
Pavel Leonidovich Ivanov
Autonomous Noncommercial Organization «International Research Center for Innovative Technologies MARTINEX»
Russian Federation
Russian Federation
Vladimir Nikolaevich Khabarov
Autonomous Noncommercial Organization «International Research Center for Innovative Technologies MARTINEX»
Russian Federation
Russian Federation
Mikhail Anatolyevich Selyanin
АНО «Международный научно-исследовательский центр инновационных технологий МАРТИНЕКС»
Russian Federation
Russian Federation
References
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2. Khabarov V.N., Boykov P.Y., Selyanin M.A. Hyaluronan: preparation, the properties, applications in biology and medicine / / practical medicine. M., 2012. - 224s. (in Russian).
3. Khabarov V.N., Selyanin M.A., Mikhailova N.P., Zelenetsky A.N. Bioactive composition based on modified hyaluronic acid // Journal of Aesthetic Medicine. - 2009. - T. 8, № 1. - C. 49-54 (in Russian).
4. Volkov. V.P et al. Patent RU 2382050 C1. Method for preparing modified ascorbic acid of cross-linked hyaluronic acid salt and based bioactive composition. 2010 (in Russian).
Review
For citations:
Karamysheva A.V., Son G.V., Perova N.M., Mnikhovich M.V., Uspenskii S.A., Ivanov P.L., Khabarov V.N., Selyanin M.A. TOXICOLOGICAL EVALUATION OF BIOACTIVE COMPOSITIONS BASED ON HYALURONIC ACID MODIFIED WITH VITAMINS AND AMINO ACIDS. Toxicological Review. 2014;(5):29-33. (In Russ.)
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