Comparative assessment of the pulmonary effect in rats to a single intratracheal administration of selenium or copper oxide nanoparticles
Marina Petrovna Sutunkova,
Larisa Ivanovna Privalova,
Yuliya Vladimirovna Ryabova,
Ilzira Amirovna Minigalieva,
Anastasiya Valeryevna Tazhigulova,
Alla Konstantinovna Labzova,
Svetlana Vladislavovna Klinova,
Svetlana Nikolaevna Solovyeva,
Ivan Nikolaevich Chernyshov,
Regina Flyuzovna Minigalieva,
Boris Aleksandrovich Katsnelson https://doi.org/10.36946/0869-7922-2021-29-6-39-46
Abstract
Introduction. Professional contact with selenium, copper and their compounds, including nanoscale forms, occurs in the metallurgical processes of copper sludge processing, copper pyrite roasting, manganese, selenium and tellurium production. The wide prevalence of selenium and copper oxide nanoparticles (SeO and CuO NPs) necessitates a comparative experimental assessment of its toxicity.
Materials and methods. The copper or selenium oxide nanoparticle suspensions or a deionized water were intratracheally administered to female rats at single time. The bronchoalveolar lavage fluid (BALF) was obtained 24 hours after administration. There were evaluated the cellular composition and the biochemical parameters of the BALF.
Results. The changes in the cellular composition of BALF demonstrate the SeO-NP and CuO-NP have a cytotoxic effect. The BALF biochemical indices were changed to a greater extent under CuO-NP. However, the phagocytic capacity of alveolar macrophages is activated under the SeO-NP.
Conclusion. The SeO-NP and CuO-NP have a cytotoxic effect. SeO-NP have a positive effect on pulmonary phagocytosis, which can presumably be associated with selenium is a biomicroelement.
About the Authors
Marina Petrovna Sutunkova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Larisa Ivanovna Privalova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Professor, MD, DSc, Head of the Laboratory of Scientific Bases for Biological Prophylaxis, FBRI YMRC PHPIW of Rospotrebnadzor, 620014, Yekaterinburg, Russia.
e-mail: privalovali@yahoo.com
Yuliya Vladimirovna Ryabova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Ilzira Amirovna Minigalieva
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Anastasiya Valeryevna Tazhigulova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Alla Konstantinovna Labzova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Svetlana Vladislavovna Klinova
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Svetlana Nikolaevna Solovyeva
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Ivan Nikolaevich Chernyshov
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Regina Flyuzovna Minigalieva
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
Boris Aleksandrovich Katsnelson
FBRI «The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor
Russian Federation
Russian Federation
References
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Review
For citations:
Sutunkova M.P., Privalova L.I., Ryabova Yu.V., Minigalieva I.A., Tazhigulova A.V., Labzova A.K., Klinova S.V., Solovyeva S.N., Chernyshov I.N., Minigalieva R.F., Katsnelson B.A. Comparative assessment of the pulmonary effect in rats to a single intratracheal administration of selenium or copper oxide nanoparticles. Toxicological Review. 2021;29(6):39-46. (In Russ.) https://doi.org/10.36946/0869-7922-2021-29-6-39-46
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