THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD
https://doi.org/10.36946/0869-7922-2017-3-27-30
Abstract
In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.
About the Authors
P. F. Zabrodskii
Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”
Russian Federation
Russian Federation
V. V. Maslyakov
Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”
Russian Federation
Russian Federation
M. S. Gromov
Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”
Russian Federation
Russian Federation
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Review
For citations:
Zabrodskii P.F., Maslyakov V.V., Gromov M.S. THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD. Toxicological Review. 2017;(3):27-30. (In Russ.) https://doi.org/10.36946/0869-7922-2017-3-27-30
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