EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT
https://doi.org/10.36946/0869-7922-2017-3-42-49
Abstract
In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after animals reached the reproductive age (2.5 months). It was found out that the drug, when administered in both doses, does not decrease the fertility of animals, does not induce morphological and pathological changes in the sex glands, and does not have toxic effect on the offspring. Obtained data characterize Kagocel as a preparation with a wide reproductive safety profile and show that it can be used in pediatric practice for infants.
About the Authors
T. A. Borovskaya
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. E. Poluektova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Vychuzhanina
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Mashanova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yu. A. Shchemerova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Borovskaya T.A., Poluektova M.E., Vychuzhanina A.V., Mashanova V.A., Shchemerova Yu.A. EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT. Toxicological Review. 2017;(3):42-49. (In Russ.) https://doi.org/10.36946/0869-7922-2017-3-42-49
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